Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

NMDA receptor 1 isoform NR1-2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
NMDA receptor 1 isoform NR1-2 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei316 – 334HelicalSequence analysisAdd BLAST19
Transmembranei385 – 411HelicalSequence analysisAdd BLAST27
Transmembranei567 – 591HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

PTM / Processingi

Proteomic databases

PaxDbiQ59GW0.
PeptideAtlasiQ59GW0.
PRIDEiQ59GW0.

Expressioni

Gene expression databases

GenevisibleiQ59GW0. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360608.

Structurei

3D structure databases

ProteinModelPortaliQ59GW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini187 – 549PBPeInterPro annotationAdd BLAST363
Domaini193 – 261Lig_chan-Glu_bdInterPro annotationAdd BLAST69

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
HOVERGENiHBG052638.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59GW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RAPGTCGWSA SARSRGTPCA TPRTLINGKN ESAHISDAVG VVAQAVHELL
60 70 80 90 100
EKENITDPPR GCVGNTNIWK TGPLFKRVLM SSKYADGVTG RVEFNEDGDR
110 120 130 140 150
KFANYSIMNL QNRKLVQVGI YNGTHVIPND RKIIWPGGET EKPRGYQMST
160 170 180 190 200
RLKIVTIHQE PFVYVKPTLS DGTCKEEFTV NGDPVKKVIC TGPNDTSPGS
210 220 230 240 250
PRHTVPQCCY GFCIDLLIKL ARTMNFTYEV HLVADGKFGT QERVNNSNKK
260 270 280 290 300
EWNGMMGELL SGQADMIVAP LTINNERAQY IKFSKPFKYQ GLTILVKKEI
310 320 330 340 350
PRSTLDSFMQ PFQSTLWLLV GLSVHVVAVM LYLLDRFSPF GRFKVNSEEE
360 370 380 390 400
EEDALTLSSA MWFSWGVLLN SGIGEGAPRS FSARILGMVW AGFAMIIVAS
410 420 430 440 450
YTANLAAFLV LDRPEERITG INDPRLRNPS DKFIYATVKQ SSVDIYFRRQ
460 470 480 490 500
VELSTMYRHM EKHNYESAAE AIQAVRDNKL HAFIWDSAVL EFEASQKCDL
510 520 530 540 550
VTTGELFFRS GFGIGMRKDS PWKQNVSLSI LKSHENGFME DLDKTWVRYQ
560 570 580 590 600
ECDSRSNAPA TLTFENMAGV FMLVAGGIVA GIFLIFIEIA YKRHKDARRK
610 620 630 640 650
QMQLAFAAVN VWRKNLQVGQ ATLRGLVPRA RPGHGPPPSP KAVALALALV
660
GRTGARSHGQ GQW
Length:663
Mass (Da):73,976
Last modified:April 26, 2005 - v1
Checksum:i84A2BB8BD5C87CB6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208999 mRNA. Translation: BAD92236.1.
RefSeqiNP_001172019.1. NM_001185090.1.
NP_001172020.1. NM_001185091.1.
UniGeneiHs.558334.

Genome annotation databases

GeneIDi2902.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208999 mRNA. Translation: BAD92236.1.
RefSeqiNP_001172019.1. NM_001185090.1.
NP_001172020.1. NM_001185091.1.
UniGeneiHs.558334.

3D structure databases

ProteinModelPortaliQ59GW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360608.

Proteomic databases

PaxDbiQ59GW0.
PeptideAtlasiQ59GW0.
PRIDEiQ59GW0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2902.

Organism-specific databases

CTDi2902.

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
HOVERGENiHBG052638.

Miscellaneous databases

GenomeRNAii2902.

Gene expression databases

GenevisibleiQ59GW0. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR018882. CaM-bd_C0_NMDA_rcpt_NR1.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF10562. CaM_bdg_C0. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59GW0_HUMAN
AccessioniPrimary (citable) accession number: Q59GW0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.