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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 103HelicalSequence analysisAdd BLAST18
Transmembranei123 – 146HelicalSequence analysisAdd BLAST24
Transmembranei215 – 234HelicalSequence analysisAdd BLAST20
Transmembranei287 – 314HelicalSequence analysisAdd BLAST28
Transmembranei457 – 479HelicalSequence analysisAdd BLAST23
Transmembranei499 – 520HelicalSequence analysisAdd BLAST22
Transmembranei578 – 607HelicalSequence analysisAdd BLAST30
Transmembranei703 – 730HelicalSequence analysisAdd BLAST28
Transmembranei781 – 802HelicalSequence analysisAdd BLAST22
Transmembranei814 – 834HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ59GU3.
PeptideAtlasiQ59GU3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266376.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 322Ion_transInterPro annotationAdd BLAST238
Domaini461 – 737Ion_transInterPro annotationAdd BLAST277
Domaini780 – 836Ion_transInterPro annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili317 – 343Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
KOiK04850.

Family and domain databases

Gene3Di1.20.120.350. 3 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF00520. Ion_trans. 3 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.

Sequencei

Sequence statusi: Fragment.

Q59GU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QLCLRHAHGV PVHHHGGLDG RAVLVSMPTS ETESVNTENV AGGDIEGENC
60 70 80 90 100
GARLAHRISK SKFSRYWRRW NRFCRRKCRA AVKSNVFYWL VIFLVFLNTL
110 120 130 140 150
TIASEHYNQP NWLTEVQDTA NKALLALFTA EMLLKMYSLG LQAYFVSLFN
160 170 180 190 200
RFDCFVVCGG ILETILVETK IMSPLGISVL RCVRLLRIFK ITRYWNSLSN
210 220 230 240 250
LVASLLNSVR SIASLLLLLF LFIIIFSLLG MQLFGGKFNF DEMQTRRSTF
260 270 280 290 300
DNFPQSLLTV FQILTGEDWN SVMYDGIMAY GGPSFPGMLV CIYFIILFIC
310 320 330 340 350
GNYILLNVFL AIAVDNLADA ESLTSAQKEE EEEKERKKLA RTASPEKKQE
360 370 380 390 400
LVEKPAVGES KEEKIELKSI TADGESPPAT KINMDDLQPN ENEDKSPYPN
410 420 430 440 450
PETTGEEDEE EPEMPVGPRP RPLSELHLKE KAVPMPEASA FFIFSSNNRF
460 470 480 490 500
RLQCHRIVND TIFTNLILFF ILLSSISLAA EDPVQHTSFR NHILGNADYV
510 520 530 540 550
FTSIFTLEII LKMTAYGAFL HKGSFCRNYF NILDLLVVSV SLISFGIQSS
560 570 580 590 600
AINVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI GNIVIVTTLL
610 620 630 640 650
QFMFACIGVQ LFKGKLYTCS DSSKQTEAEC KGNYITYKDG EVDHPIIQPR
660 670 680 690 700
SWENSKFDFD NVLAAMMALF TVSTFEGWPE LLYRSIDSHT EDKGPIYNYR
710 720 730 740 750
VEISIFFIIY IIIIAFFMMN IFVGFVIVTF QEQGEQEYKN CELDKNQRQC
760 770 780 790 800
VEYALKARPL RRYIPKNQHQ YKVWYVVNST YFEYLMFVLI LLNTICLAMQ
810 820 830 840
HYGQSCLFKI AMNILNMLFT GLFTVEMILK LIAFKPKVGL
Length:840
Mass (Da):95,954
Last modified:April 26, 2005 - v1
Checksum:i0ECC7A56D6714F8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209016 mRNA. Translation: BAD92253.1.
RefSeqiNP_955630.3. NM_199460.3.
UniGeneiHs.118262.
Hs.690010.

Genome annotation databases

GeneIDi775.
KEGGihsa:775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209016 mRNA. Translation: BAD92253.1.
RefSeqiNP_955630.3. NM_199460.3.
UniGeneiHs.118262.
Hs.690010.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266376.

Proteomic databases

PaxDbiQ59GU3.
PeptideAtlasiQ59GU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi775.
KEGGihsa:775.

Organism-specific databases

CTDi775.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
KOiK04850.

Miscellaneous databases

GenomeRNAii775.

Family and domain databases

Gene3Di1.20.120.350. 3 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF00520. Ion_trans. 3 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59GU3_HUMAN
AccessioniPrimary (citable) accession number: Q59GU3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 5, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.