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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in opposite effects on the channel function.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei86 – 103HelicalSequence analysisAdd BLAST18
Transmembranei123 – 146HelicalSequence analysisAdd BLAST24
Transmembranei215 – 234HelicalSequence analysisAdd BLAST20
Transmembranei287 – 314HelicalSequence analysisAdd BLAST28
Transmembranei457 – 479HelicalSequence analysisAdd BLAST23
Transmembranei499 – 520HelicalSequence analysisAdd BLAST22
Transmembranei578 – 607HelicalSequence analysisAdd BLAST30
Transmembranei703 – 730HelicalSequence analysisAdd BLAST28
Transmembranei781 – 802HelicalSequence analysisAdd BLAST22
Transmembranei814 – 834HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiQ59GU3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 322Ion_transInterPro annotationAdd BLAST238
Domaini461 – 737Ion_transInterPro annotationAdd BLAST277
Domaini780 – 836Ion_transInterPro annotationAdd BLAST57

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili317 – 343Sequence analysisAdd BLAST27

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
HOGENOMiHOG000231529
HOVERGENiHBG050763
KOiK04850

Family and domain databases

Gene3Di1.20.120.350, 3 hits
InterProiView protein in InterPro
IPR005821 Ion_trans_dom
IPR005451 VDCC_L_a1csu
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF00520 Ion_trans, 3 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01635 LVDCCALPHA1C

Sequencei

Sequence statusi: Fragment.

Q59GU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QLCLRHAHGV PVHHHGGLDG RAVLVSMPTS ETESVNTENV AGGDIEGENC
60 70 80 90 100
GARLAHRISK SKFSRYWRRW NRFCRRKCRA AVKSNVFYWL VIFLVFLNTL
110 120 130 140 150
TIASEHYNQP NWLTEVQDTA NKALLALFTA EMLLKMYSLG LQAYFVSLFN
160 170 180 190 200
RFDCFVVCGG ILETILVETK IMSPLGISVL RCVRLLRIFK ITRYWNSLSN
210 220 230 240 250
LVASLLNSVR SIASLLLLLF LFIIIFSLLG MQLFGGKFNF DEMQTRRSTF
260 270 280 290 300
DNFPQSLLTV FQILTGEDWN SVMYDGIMAY GGPSFPGMLV CIYFIILFIC
310 320 330 340 350
GNYILLNVFL AIAVDNLADA ESLTSAQKEE EEEKERKKLA RTASPEKKQE
360 370 380 390 400
LVEKPAVGES KEEKIELKSI TADGESPPAT KINMDDLQPN ENEDKSPYPN
410 420 430 440 450
PETTGEEDEE EPEMPVGPRP RPLSELHLKE KAVPMPEASA FFIFSSNNRF
460 470 480 490 500
RLQCHRIVND TIFTNLILFF ILLSSISLAA EDPVQHTSFR NHILGNADYV
510 520 530 540 550
FTSIFTLEII LKMTAYGAFL HKGSFCRNYF NILDLLVVSV SLISFGIQSS
560 570 580 590 600
AINVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI GNIVIVTTLL
610 620 630 640 650
QFMFACIGVQ LFKGKLYTCS DSSKQTEAEC KGNYITYKDG EVDHPIIQPR
660 670 680 690 700
SWENSKFDFD NVLAAMMALF TVSTFEGWPE LLYRSIDSHT EDKGPIYNYR
710 720 730 740 750
VEISIFFIIY IIIIAFFMMN IFVGFVIVTF QEQGEQEYKN CELDKNQRQC
760 770 780 790 800
VEYALKARPL RRYIPKNQHQ YKVWYVVNST YFEYLMFVLI LLNTICLAMQ
810 820 830 840
HYGQSCLFKI AMNILNMLFT GLFTVEMILK LIAFKPKVGL
Length:840
Mass (Da):95,954
Last modified:April 26, 2005 - v1
Checksum:i0ECC7A56D6714F8E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209016 mRNA Translation: BAD92253.1
RefSeqiNP_955630.3, NM_199460.3
UniGeneiHs.118262
Hs.690010

Genome annotation databases

GeneIDi775
KEGGihsa:775

Similar proteinsi

Entry informationi

Entry nameiQ59GU3_HUMAN
AccessioniPrimary (citable) accession number: Q59GU3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health