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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Calcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotationSAAS annotation

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei86 – 10318HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14624HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23420HelicalSequence analysisAdd
BLAST
Transmembranei287 – 31428HelicalSequence analysisAdd
BLAST
Transmembranei457 – 47923HelicalSequence analysisAdd
BLAST
Transmembranei499 – 52022HelicalSequence analysisAdd
BLAST
Transmembranei578 – 60730HelicalSequence analysisAdd
BLAST
Transmembranei703 – 73028HelicalSequence analysisAdd
BLAST
Transmembranei781 – 80222HelicalSequence analysisAdd
BLAST
Transmembranei814 – 83421HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ59GU3.
PeptideAtlasiQ59GU3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000266376.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini85 – 322238Ion_transInterPro annotationAdd
BLAST
Domaini461 – 737277Ion_transInterPro annotationAdd
BLAST
Domaini780 – 83657Ion_transInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili317 – 34327Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
KOiK04850.

Family and domain databases

Gene3Di1.20.120.350. 3 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF00520. Ion_trans. 3 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.

Sequencei

Sequence statusi: Fragment.

Q59GU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QLCLRHAHGV PVHHHGGLDG RAVLVSMPTS ETESVNTENV AGGDIEGENC
60 70 80 90 100
GARLAHRISK SKFSRYWRRW NRFCRRKCRA AVKSNVFYWL VIFLVFLNTL
110 120 130 140 150
TIASEHYNQP NWLTEVQDTA NKALLALFTA EMLLKMYSLG LQAYFVSLFN
160 170 180 190 200
RFDCFVVCGG ILETILVETK IMSPLGISVL RCVRLLRIFK ITRYWNSLSN
210 220 230 240 250
LVASLLNSVR SIASLLLLLF LFIIIFSLLG MQLFGGKFNF DEMQTRRSTF
260 270 280 290 300
DNFPQSLLTV FQILTGEDWN SVMYDGIMAY GGPSFPGMLV CIYFIILFIC
310 320 330 340 350
GNYILLNVFL AIAVDNLADA ESLTSAQKEE EEEKERKKLA RTASPEKKQE
360 370 380 390 400
LVEKPAVGES KEEKIELKSI TADGESPPAT KINMDDLQPN ENEDKSPYPN
410 420 430 440 450
PETTGEEDEE EPEMPVGPRP RPLSELHLKE KAVPMPEASA FFIFSSNNRF
460 470 480 490 500
RLQCHRIVND TIFTNLILFF ILLSSISLAA EDPVQHTSFR NHILGNADYV
510 520 530 540 550
FTSIFTLEII LKMTAYGAFL HKGSFCRNYF NILDLLVVSV SLISFGIQSS
560 570 580 590 600
AINVVKILRV LRVLRPLRAI NRAKGLKHVV QCVFVAIRTI GNIVIVTTLL
610 620 630 640 650
QFMFACIGVQ LFKGKLYTCS DSSKQTEAEC KGNYITYKDG EVDHPIIQPR
660 670 680 690 700
SWENSKFDFD NVLAAMMALF TVSTFEGWPE LLYRSIDSHT EDKGPIYNYR
710 720 730 740 750
VEISIFFIIY IIIIAFFMMN IFVGFVIVTF QEQGEQEYKN CELDKNQRQC
760 770 780 790 800
VEYALKARPL RRYIPKNQHQ YKVWYVVNST YFEYLMFVLI LLNTICLAMQ
810 820 830 840
HYGQSCLFKI AMNILNMLFT GLFTVEMILK LIAFKPKVGL
Length:840
Mass (Da):95,954
Last modified:April 26, 2005 - v1
Checksum:i0ECC7A56D6714F8E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209016 mRNA. Translation: BAD92253.1.
RefSeqiNP_955630.3. NM_199460.3.
UniGeneiHs.118262.
Hs.690010.

Genome annotation databases

GeneIDi775.
KEGGihsa:775.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209016 mRNA. Translation: BAD92253.1.
RefSeqiNP_955630.3. NM_199460.3.
UniGeneiHs.118262.
Hs.690010.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000266376.

Proteomic databases

PaxDbiQ59GU3.
PeptideAtlasiQ59GU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi775.
KEGGihsa:775.

Organism-specific databases

CTDi775.

Phylogenomic databases

eggNOGiKOG2301. Eukaryota.
ENOG410XNP6. LUCA.
HOGENOMiHOG000231529.
HOVERGENiHBG050763.
KOiK04850.

Miscellaneous databases

GenomeRNAii775.

Family and domain databases

Gene3Di1.20.120.350. 3 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR005451. VDCC_L_a1csu.
IPR005446. VDCC_L_a1su.
IPR002077. VDCCAlpha1.
[Graphical view]
PANTHERiPTHR10037:SF188. PTHR10037:SF188. 1 hit.
PfamiPF00520. Ion_trans. 3 hits.
[Graphical view]
PRINTSiPR00167. CACHANNEL.
PR01630. LVDCCALPHA1.
PR01635. LVDCCALPHA1C.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59GU3_HUMAN
AccessioniPrimary (citable) accession number: Q59GU3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.