Q59GS8 (Q59GS8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Complement component 5 variant EMBL BAD92268.1
Organism	Homo sapiens (Human) EMBL BAD92268.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1106 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	complement activation Inferred from electronic annotation. Source: InterPro inflammatory response Inferred from electronic annotation. Source: InterPro negative regulation of endopeptidase activity Inferred from electronic annotation. Source: GOC
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro
Molecular_function	endopeptidase inhibitor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92268.1

Sequences

	Sequence		Length	Mass (Da)
	Q59GS8 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: F0CC415C9FAE2D6A	FASTA	1,106	123,351
	10 20 30 40 50 60 GRAGEVRALS SGAQRRGSHF VVLCRLPRGR ARVVGASLSH APLPLRYCWK GRGGVSRLFC 70 80 90 100 110 120 SQRARMPGSL GREASGRAGP TGCGAFAFGL RCRYVISAPK IFRVGASENI VIQVYGYTEA 130 140 150 160 170 180 FDATISIKSY PDKKFSYSSG HVHLSSENKF QNSAILTIQP KQLPGGQNPV SYVYLEVVSK 190 200 210 220 230 240 HFSKSKRMPI TYDNGFLFIH TDKPVYTPDQ SVKVRVYSLN DDLKPAKRET VLTFIDPEGS 250 260 270 280 290 300 EVDMVEEIDH IGIISFPDFK IPSNPRYGMW TIKAKYKEDF STTGTAYFEV KEYVLPHFSV 310 320 330 340 350 360 SIEPEYNFIG YKNFKNFEIT IKARYFYNKV VTEADVYITF GIREDLKDDQ KEMMQTAMQN 370 380 390 400 410 420 TMLINGIAQV TFDSETAVKE LSYYSLEDLN NKYLYIAVTV IESTGGFSEE AEIPGIKYVL 430 440 450 460 470 480 SPYKLNLVAT PLFLKPGIPY PIKVQVKDSL DQLVGGVPVT LNAQTIDVNQ ETSDLDPSKS 490 500 510 520 530 540 VTRVDDGVAS FVLNLPSGVT VLEFNVKTDA PDLPEENQAR EGYRAIAYSS LSQSYLYIDW 550 560 570 580 590 600 TDNHKALLVG EHLNIIVTPK SPYIDKITHY NYLILSKGKI IHFGTREKFS DASYQSINIP 610 620 630 640 650 660 VTQNMVPSSR LLVYYIVTGE QTAELVSDSV WLNIEEKCGN QLQVHLSPDA DAYSPGQTVS 670 680 690 700 710 720 LNMATGMDSW VALAAVDSAV YGVQRGAKKP LERVFQFLEK SDLGCGAGGG LNNANVFHLA 730 740 750 760 770 780 GLTFLTNANA DDSQENDEPC KEILRPRRTL QKKIEEIAAK YKHSVVKKCC YDGACVNNDE 790 800 810 820 830 840 TCEQRAARIS LGPRCIKAFT ECCVVASQLR ANISHKDMQL GRLHMKTLLP VSKPEIRSYF 850 860 870 880 890 900 PESWLWEVHL VPRRKQLQFA LPDSLTTWEI QGVGISNTGI CVADTVKAKV FKDVFLEMNI 910 920 930 940 950 960 PYSVVRGEQI QLKGTVYNYR TSGMQFCVKM SAVEGICTSE SPVIDHQGTK SSKCVRQKVE 970 980 990 1000 1010 1020 GSSSHLVTFT VLPLEIGLHN INFSLETWFG KEILVKTLRV VPEGVKRESY SGVTLDPRGI 1030 1040 1050 1060 1070 1080 YGTISRRKEF PYRIPLDLVP KTEIKRILSV KGLLVGEILS AVLSQEGINI LTHLPKGSAE 1090 1100 AELMSVVPVF YVFLPGNRKS LEHFSF

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92268.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209031 mRNA. Translation: BAD92268.1.
IPI	IPI00816741.
UniGene	Hs.494997.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q59GS8.
Proteomic databases
PRIDE	Q59GS8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc010mvn.1. human.
Phylogenomic databases
HOGENOM	HOG000231860.
HOVERGEN	HBG098067.
Gene expression databases
ArrayExpress	Q59GS8.
Bgee	Q59GS8.
Family and domain databases
Gene3D	1.20.91.20. 1 hit.
InterPro	IPR002890. A2M_N. IPR011625. A2M_N_2. IPR000020. Anaphylatoxin/fibulin. IPR018081. Anaphylatoxin_. IPR001840. Anaphylatoxn. IPR001599. Macroglobln_a2. [Graphical view]
Pfam	PF00207. A2M. 1 hit. PF01835. A2M_N. 1 hit. PF07703. A2M_N_2. 1 hit. PF01821. ANATO. 1 hit. [Graphical view]
PRINTS	PR00004. ANAPHYLATOXN.
SMART	SM00104. ANATO. 1 hit. [Graphical view]
SUPFAM	SSF47686. Anaphylatoxin. 1 hit.
PROSITE	PS01177. ANAPHYLATOXIN_1. 1 hit. PS01178. ANAPHYLATOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59GS8_HUMAN

Accession

Primary (citable) accession number: Q59GS8

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	March 6, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.