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Protein
Submitted name:

Complement component 5 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Complement component 5 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

MaxQBiQ59GS8.
PaxDbiQ59GS8.
PeptideAtlasiQ59GS8.
PRIDEiQ59GS8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000223642.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini769 – 803Anaphylatoxin-likeInterPro annotationAdd BLAST35

Phylogenomic databases

eggNOGiKOG1366. Eukaryota.
ENOG410XRED. LUCA.
HOGENOMiHOG000231860.
HOVERGENiHBG098067.

Family and domain databases

Gene3Di1.20.91.20. 1 hit.
InterProiIPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
IPR001599. Macroglobln_a2.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF01821. ANATO. 1 hit.
[Graphical view]
PRINTSiPR00004. ANAPHYLATOXN.
SMARTiSM01360. A2M. 1 hit.
SM01359. A2M_N_2. 1 hit.
SM00104. ANATO. 1 hit.
[Graphical view]
SUPFAMiSSF47686. SSF47686. 1 hit.
PROSITEiPS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59GS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GRAGEVRALS SGAQRRGSHF VVLCRLPRGR ARVVGASLSH APLPLRYCWK
60 70 80 90 100
GRGGVSRLFC SQRARMPGSL GREASGRAGP TGCGAFAFGL RCRYVISAPK
110 120 130 140 150
IFRVGASENI VIQVYGYTEA FDATISIKSY PDKKFSYSSG HVHLSSENKF
160 170 180 190 200
QNSAILTIQP KQLPGGQNPV SYVYLEVVSK HFSKSKRMPI TYDNGFLFIH
210 220 230 240 250
TDKPVYTPDQ SVKVRVYSLN DDLKPAKRET VLTFIDPEGS EVDMVEEIDH
260 270 280 290 300
IGIISFPDFK IPSNPRYGMW TIKAKYKEDF STTGTAYFEV KEYVLPHFSV
310 320 330 340 350
SIEPEYNFIG YKNFKNFEIT IKARYFYNKV VTEADVYITF GIREDLKDDQ
360 370 380 390 400
KEMMQTAMQN TMLINGIAQV TFDSETAVKE LSYYSLEDLN NKYLYIAVTV
410 420 430 440 450
IESTGGFSEE AEIPGIKYVL SPYKLNLVAT PLFLKPGIPY PIKVQVKDSL
460 470 480 490 500
DQLVGGVPVT LNAQTIDVNQ ETSDLDPSKS VTRVDDGVAS FVLNLPSGVT
510 520 530 540 550
VLEFNVKTDA PDLPEENQAR EGYRAIAYSS LSQSYLYIDW TDNHKALLVG
560 570 580 590 600
EHLNIIVTPK SPYIDKITHY NYLILSKGKI IHFGTREKFS DASYQSINIP
610 620 630 640 650
VTQNMVPSSR LLVYYIVTGE QTAELVSDSV WLNIEEKCGN QLQVHLSPDA
660 670 680 690 700
DAYSPGQTVS LNMATGMDSW VALAAVDSAV YGVQRGAKKP LERVFQFLEK
710 720 730 740 750
SDLGCGAGGG LNNANVFHLA GLTFLTNANA DDSQENDEPC KEILRPRRTL
760 770 780 790 800
QKKIEEIAAK YKHSVVKKCC YDGACVNNDE TCEQRAARIS LGPRCIKAFT
810 820 830 840 850
ECCVVASQLR ANISHKDMQL GRLHMKTLLP VSKPEIRSYF PESWLWEVHL
860 870 880 890 900
VPRRKQLQFA LPDSLTTWEI QGVGISNTGI CVADTVKAKV FKDVFLEMNI
910 920 930 940 950
PYSVVRGEQI QLKGTVYNYR TSGMQFCVKM SAVEGICTSE SPVIDHQGTK
960 970 980 990 1000
SSKCVRQKVE GSSSHLVTFT VLPLEIGLHN INFSLETWFG KEILVKTLRV
1010 1020 1030 1040 1050
VPEGVKRESY SGVTLDPRGI YGTISRRKEF PYRIPLDLVP KTEIKRILSV
1060 1070 1080 1090 1100
KGLLVGEILS AVLSQEGINI LTHLPKGSAE AELMSVVPVF YVFLPGNRKS

LEHFSF
Length:1,106
Mass (Da):123,351
Last modified:April 26, 2005 - v1
Checksum:iF0CC415C9FAE2D6A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209031 mRNA. Translation: BAD92268.1.
RefSeqiNP_001304092.1. NM_001317163.1.
UniGeneiHs.494997.

Genome annotation databases

GeneIDi727.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209031 mRNA. Translation: BAD92268.1.
RefSeqiNP_001304092.1. NM_001317163.1.
UniGeneiHs.494997.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000223642.

Proteomic databases

MaxQBiQ59GS8.
PaxDbiQ59GS8.
PeptideAtlasiQ59GS8.
PRIDEiQ59GS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi727.

Organism-specific databases

CTDi727.

Phylogenomic databases

eggNOGiKOG1366. Eukaryota.
ENOG410XRED. LUCA.
HOGENOMiHOG000231860.
HOVERGENiHBG098067.

Family and domain databases

Gene3Di1.20.91.20. 1 hit.
InterProiIPR002890. A2M_N.
IPR011625. A2M_N_2.
IPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
IPR001599. Macroglobln_a2.
[Graphical view]
PfamiPF00207. A2M. 1 hit.
PF01835. A2M_N. 1 hit.
PF07703. A2M_N_2. 1 hit.
PF01821. ANATO. 1 hit.
[Graphical view]
PRINTSiPR00004. ANAPHYLATOXN.
SMARTiSM01360. A2M. 1 hit.
SM01359. A2M_N_2. 1 hit.
SM00104. ANATO. 1 hit.
[Graphical view]
SUPFAMiSSF47686. SSF47686. 1 hit.
PROSITEiPS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ59GS8_HUMAN
AccessioniPrimary (citable) accession number: Q59GS8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 6, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.