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Protein

Alpha-1,4 glucan phosphorylase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.UniRule annotation

Catalytic activityi

((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,4 glucan phosphorylaseUniRule annotation (EC:2.4.1.1UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 865845Alpha-1,4 glucan phosphorylaseSequence analysisPRO_5004252624Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PaxDbiQ59GM9.
PRIDEiQ59GM9.

Interactioni

Protein-protein interaction databases

IntActiQ59GM9. 2 interactions.
STRINGi9606.ENSP00000216962.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycogen phosphorylase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG2099. Eukaryota.
COG0058. LUCA.
HOGENOMiHOG000278444.
HOVERGENiHBG006848.

Family and domain databases

InterProiIPR011833. Glycg_phsphrylas.
IPR000811. Glyco_trans_35.
[Graphical view]
PANTHERiPTHR11468. PTHR11468. 1 hit.
PfamiPF00343. Phosphorylase. 1 hit.
[Graphical view]
PIRSFiPIRSF000460. Pprylas_GlgP. 1 hit.
TIGRFAMsiTIGR02093. P_ylase. 1 hit.
PROSITEiPS00102. PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59GM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IPAFACAAAF LLHLFSSASA GAMAKPLTDS EKRKQISVRG LAGLGDVAEV
60 70 80 90 100
RKSFNRHLHF TLVKDRNVAT PRDYFFALAH TVRDHLVGRW IRTQQHYYER
110 120 130 140 150
DPKRIYYLSL EFYMGRTLQN TMVNLGLQNA CDEAIYQLGL DLEELEEIEE
160 170 180 190 200
DAGLGNGGLG RLAACFLDSM ATLGLAAYGY GIRYEFGIFN QKIVNGWQVE
210 220 230 240 250
EADDWLRYGN PWEKARPEYM LPVHFYGRVE HTPDGVKWLD TQVVLAMPYD
260 270 280 290 300
TPVPGYKNNT VNTMRLWSAK APNDFKLQDF NVGDYIEAVL DRNLAENISR
310 320 330 340 350
VLYPNDNFFE GKELRLKQEY FVVASTLQDI IRRFKSSKFG CRDPVRTCFE
360 370 380 390 400
TFPDKVAIQL NDTHPALSIP ELMRILVDVE KVDWDKAWEI TKKTCAYTNH
410 420 430 440 450
TVLPEALERW PVSMFEKLLP RHLEIIYAIN QRHLDHVAAL FPGDVDRLRR
460 470 480 490 500
MSVIEEGDCK RINMAHLCVI GSHAVNGVAR IHSEIVKQSV FKDFYELEPE
510 520 530 540 550
KFQNKTNGIT PRRWLLLCNP GLANTIVEKI GEEFLTDLSQ LKKLLPLVSD
560 570 580 590 600
EVFIRDVAKV KQENKLKFSA FLEKEYKVKI NPSSMFDVHV KRIHEYKRQL
610 620 630 640 650
LNCLHVVTLY NRIKRDPAKA FVPRTVMIGG KAAPGYHMAK LIIKLVTSIG
660 670 680 690 700
DVVNHDPVVG DRLKVIFLEN YRVSLAEKVI PAADLSQQIS TAGTEASGTG
710 720 730 740 750
NMKFMLNGAL TIGTMDGANV EMAEEAGAEN LFIFGLRVED VEALDRKGYN
760 770 780 790 800
AREYYDHLPE LKQAVDQISS GFFSPKEPDC FKDIVNMLMH HDRFKVFADY
810 820 830 840 850
EAYMQCQAQV DQLYRNPKEW TKKVIRNIAC SGKFSSDRTI TEYAREIWGV
860
EPSDLQIPPP NIPRD
Length:865
Mass (Da):98,829
Last modified:April 26, 2005 - v1
Checksum:i97DB1992902D8424
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209080 mRNA. Translation: BAD92317.1.
UniGeneiHs.368157.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209080 mRNA. Translation: BAD92317.1.
UniGeneiHs.368157.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ59GM9. 2 interactions.
STRINGi9606.ENSP00000216962.

Proteomic databases

PaxDbiQ59GM9.
PRIDEiQ59GM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2099. Eukaryota.
COG0058. LUCA.
HOGENOMiHOG000278444.
HOVERGENiHBG006848.

Family and domain databases

InterProiIPR011833. Glycg_phsphrylas.
IPR000811. Glyco_trans_35.
[Graphical view]
PANTHERiPTHR11468. PTHR11468. 1 hit.
PfamiPF00343. Phosphorylase. 1 hit.
[Graphical view]
PIRSFiPIRSF000460. Pprylas_GlgP. 1 hit.
TIGRFAMsiTIGR02093. P_ylase. 1 hit.
PROSITEiPS00102. PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59GM9_HUMAN
AccessioniPrimary (citable) accession number: Q59GM9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 16, 2016
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.