Unreviewed, UniProtKB/TrEMBL Q59GM5 (Q59GM5_HUMAN)

Names and origin

Protein names	Submitted name:     Sulfonylurea receptor 1 variant EMBL BAD92321.1
Organism	Homo sapiens (Human) EMBL BAD92321.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1011 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily.

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000684V4 Nucleotide-binding
Molecular function	Receptor EMBL BAD92321.1
Gene Ontology (GO)
Biological process	potassium ion transport Inferred from electronic annotation. Source: InterPro transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro sulfonylurea receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92321.1

Sequences

	Sequence		Length	Mass (Da)
	Q59GM5-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 7E6EF1C557B28113	FASTA	1,011	113,422
	10 20 30 40 50 60 RSQLSPSPAR ARAAMPLAFC GSENHSAAYR VDQGVLNNGC FVDALNVVPH VFLLFITFPI 70 80 90 100 110 120 LFIGWGSQSS KVHIHHSTWL HFPGHNLRWI LTFMLLFVLV CEIAEGILSD GVTESHHLHL 130 140 150 160 170 180 YMPAGMAFMA AVTSVVYYHN IETSNFPKLL IALLVYWTLA FITKTIKFVK FLDHAIGFSQ 190 200 210 220 230 240 LRFCLTGLLV ILYGMLLLVE VNVIRVRRYI FFKTPREVKP PEDLQDLGVR FLQPFVNLLS 250 260 270 280 290 300 KGTYWWMNAF IKTAHKKPID LRAIGKLPIA MRALTNYQRL CEAFDAQVRK DIQGTQGARA 310 320 330 340 350 360 IWQALSHAFG RRLVLSSTFR ILADLLGFAG PLCIFGIVDH LGKENDVFQP KTQFLGVYFV 370 380 390 400 410 420 SSQEFLANAY VLAVLLFLAL LLQRTFLQAS YYVAIETGIN LRGAIQTKIY NKIMHLSTSN 430 440 450 460 470 480 LSMGEMTAGQ ICNLVAIDTN QLMWFFFLCP NLWAMPVQII VGVILLYYIL GVSALIGAAV 490 500 510 520 530 540 IILLAPVQYF VATKLSQAQR STLEYSNERL KQTNEMLRGI KLLKLYAWEN IFRTRVETTR 550 560 570 580 590 600 RKEMTSLRAF AIYTSISIFM NTAIPIAAVL ITFVGHVSFF KEADFSPSVA FASLSLFHIL 610 620 630 640 650 660 VTPLFLLSSV VRSTVKALVS AEIREEQCAP HEPTPQGPAS KYQAVPLRVV NRKRPAREDC 670 680 690 700 710 720 RGLTGPLQSL VPSADGDADN CCVQIMGGYF TWTPDGIPTL SNITIRIPRG QLTMIVGQVG 730 740 750 760 770 780 CGKSSLLLAA LGEMQKVSGA VFWSSLPDSE IGEDPSPERE TATDLDIRKR GPVAYASQKP 790 800 810 820 830 840 WLLNATVEEN IIFESPFNKQ RYKMVIEACS LQPDIDILPH GDQTQIGERG INLSGGQRQR 850 860 870 880 890 900 ISVARALYQH ANVVFLDDPF SALDIHLSDH LMQAGILELL RDDKRTVVLV THKLQYLPHA 910 920 930 940 950 960 DWIIAMKDGT IQREGTLKDF QRSECQLFEH WKTLMNRQDQ ELEKRRQLRA RRMTTCRPCC 970 980 990 1000 1010 TSVLRSHGEP APSTCPPPAS CSCRCWSSHS CSSTWSWWPS TTGWPSGPTA P

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92321.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209084 mRNA. Translation: BAD92321.1.
IPI	IPI00555831.
UniGene	Hs.54470
3D structure databases
SMR	Q59GM5. Positions 300-924.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59GM5.
Proteomic databases
PRIDE	Q59GM5.
Genome annotation databases
Ensembl	ENST00000379493; ENSP00000368807; ENSG00000006071; Homo sapiens. [Genome view]
Organism-specific databases
HGNC	HGNC:59. ABCC8.
Phylogenomic databases
HOVERGEN	Q59GM5.
Gene expression databases
ArrayExpress	Q59GM5.
Bgee	Q59GM5.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR003593. ATPase_AAA+_core. IPR000388. Sulphorea_rcpt_N. IPR000844. Surea_rcpt_1_N. [Graphical view]
Pfam	PF00664. ABC_membrane. 1 hit. PF00005. ABC_tran. 1 hit. [Graphical view]
PRINTS	PR01093. SULFNYLUR1. PR01092. SULFNYLUREAR.
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS50929. ABC_TM1F. 1 hit. PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59GM5_HUMAN

Accession

Primary (citable) accession number: Q59GM5

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	February 9, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.