Q59GM4 (Q59GM4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: PTK2B protein tyrosine kinase 2 beta isoform a variant EMBL BAD92322.1
Organism	Homo sapiens (Human) EMBL BAD92322.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	802 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS008266

Ontologies

Keywords
Ligand	ATP-binding SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase SAAS SAAS008266
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA cytoskeleton Inferred from electronic annotation. Source: InterPro nucleus Inferred from direct assay. Source: HPA
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92322.1

Sequences

	Sequence		Length	Mass (Da)
	Q59GM4 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 334A5A02CC8A6F66	FASTA	802	92,327
	10 20 30 40 50 60 LLPERMSGVS EPLSRVKLGT LRRPEGPAEP MVVVPVDVEK EDVRILKVCF YSNSFNPGKN 70 80 90 100 110 120 FKLVKCTVQT EIREIITSIL LSGRIGPNIR LAECYGLRLK HMKSDEIHWL HPQMTVGEVQ 130 140 150 160 170 180 DKYECLHVEA EWRYDLQIRY LPEDFMESLK EDRTTLLYFY QQLRNDYMQR YASKVSEGMA 190 200 210 220 230 240 LQLGCLELRR FFKDMPHNAL DKKSNFELLE KEVGLDLFFP KQMQENLKPK QFRKMIQQTF 250 260 270 280 290 300 QQYASLREEE CVMKFFNTLA GFANIDQETY RCELIQGWNI TVDLVIGPKG IRQLTSQDAK 310 320 330 340 350 360 PTCLAEFKQI RSIRCLPLEE GQAVLQLGIE GAPQALSIKT SSLAEAENMA DLIDGYCRLQ 370 380 390 400 410 420 GEHQGSLIIH PRKDGEKRNS LPQIPMLNLE ARRSHLSESC SIESDIYAEI PDETLRRPGG 430 440 450 460 470 480 PQYGIAREDV VLNRILGEGF FGEVYEGVYT NHKGEKINVA VKTCKKDCTL DNKEKFMSEA 490 500 510 520 530 540 VIMKNLDHPH IVKLIGIIEE EPTWIIMELY PYGELGHYLE RNKNSLKVLT LVLYSLQICK 550 560 570 580 590 600 AMAYLESINC VHRDIAVRNI LVASPECVKL GDFGLSRYIE DEDYYKASVT RLPIKWMSPE 610 620 630 640 650 660 SINFRRFTTA SDVWMFAVCM WEILSFGKQP FFWLENKDVI GVLEKGDRLP KPDLCPPVLY 670 680 690 700 710 720 TLMTRCWDYD PSDRPRFTEL VCSLSDVYQM EKDIAMEQER NARYRTPKIL EPTAFQEPPP 730 740 750 760 770 780 KPSRPKYRPP PQTNLLAPKL QFQVPEGLCA SSPTLTSPME YPSPVNSLHT PPLHRHNVFK 790 800 RHSMREEDFI QPSSRGPAAV GG

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92322.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209085 mRNA. Translation: BAD92322.1.
IPI	IPI00793811.
UniGene	Hs.491322. Hs.735450.
3D structure databases
ProteinModelPortal	Q59GM4.
SMR	Q59GM4. Positions 44-697.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59GM4.
Proteomic databases
PRIDE	Q59GM4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG004018.
Gene expression databases
ArrayExpress	Q59GM4.
Family and domain databases
Gene3D	1.20.80.10. 1 hit.
InterPro	IPR019749. Band_41_domain. IPR014352. FERM/acyl-CoA-bd_prot_3-hlx. IPR019748. FERM_central. IPR000299. FERM_domain. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF00373. FERM_M. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00295. B41. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF47031. FERM_3-hlx. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50057. FERM_3. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59GM4_HUMAN

Accession

Primary (citable) accession number: Q59GM4

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	March 6, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.