Q59GL6 (Q59GL6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Mitogen-activated protein kinase kinase kinase 5 variant EMBL BAD92330.1
Organism	Homo sapiens (Human) EMBL BAD92330.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1455 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 protein kinase domain. SAAS SAAS013761

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304 SAAS SAAS013761 Nucleotide-binding
Molecular function	Kinase SAAS SAAS013761 EMBL BAD92330.1 Transferase
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92330.1

Sequences

	Sequence		Length	Mass (Da)
	Q59GL6 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: A9C71935AB18A0E0	FASTA	1,455	162,958
	10 20 30 40 50 60 TLQRASGAAT EAPRRSEPPP GSGVPSGERA PERRRRRGGE GAARDGSCLA RRARSSPELW 70 80 90 100 110 120 LARRCGWAGD AAAVAARPGE MSTEADEGIT FSVPPFAPSG FCTIPEGGIC RRGGAAAVGE 130 140 150 160 170 180 GEEHQLPPPP PGSFWNVESA AAPGIGCPAA TSSSSATRGR GSSVGGGSRR TTVAYVINEA 190 200 210 220 230 240 SQGQLVVAES EALQSLREAC ETVGATLETL HFGKLDFGET TVLDRFYNAD IAVVEMSDAF 250 260 270 280 290 300 RQPSLFYHLG VRESFSMANN IILYCDTNSD SLQSLKEIIC QKNTMCTGNY TFVPYMITPH 310 320 330 340 350 360 NKVYCCDSSF MKGLTELMQP NFELLLGPIC LPLVDRFIQL LKVAQASSSQ YFRESILNDI 370 380 390 400 410 420 RKARNLYTGK ELAAELARIR QRVDNIEVLT ADIVINLLLS YRDIQDYDSI VKLVETLEKL 430 440 450 460 470 480 PTFDLASHHH VKFHYAFALN RRNLPGDRAK ALDIMIPMVQ SEGQVASDMY CLVGRIYKDM 490 500 510 520 530 540 FLDSNFTDTE SRDHGASWFK KAFESEPTLQ SGINYAVLLL AAGHQFESSF ELRKVGVKLS 550 560 570 580 590 600 SLLGKKGNLE KLQSYWEVGF FLGASVLAND HMRVIQASEK LFKLKTPAWY LKSIVETILI 610 620 630 640 650 660 YKHFVKLTTE QPVAKQELVD FWMDFLVEAT KTDVTVVRFP VLILEPTKIY QPSYLSINNE 670 680 690 700 710 720 VEEKTISIWH VLPDDKKGIH EWNFSASSVR GVSISKFEER CCFLYVLHNS DDFQIYFCTE 730 740 750 760 770 780 PDCKKFFEMV NTITEEKGRS TEEGDCESDL LEYDYEYDEN GDRVVLGKGT YGIVYAGRDL 790 800 810 820 830 840 SNQVRIAIKE IPERDSRYSQ PLHEEIALHK HLKHKNIVQY LGSFSENGFI KIFMEQVPGG 850 860 870 880 890 900 SLSALLRSKW GPLKDNEQTI GFYTKQILEG LKYLHDNQIV HRDIKGDNVL INTYSGVLKI 910 920 930 940 950 960 SDFGTSKRLA GINPCTETFT GTLQYMAPEI IDKGPRGYGK AADIWSLGCT IIEMATGKPP 970 980 990 1000 1010 1020 FYELGEPQAA MFKVGMFKVH PEIPESMSAE AKAFILKCFE PDPDKRACAN DLLVDEFLKV 1030 1040 1050 1060 1070 1080 SSKKKKTQPK LSALSAGSNE YLRSISLPVP VLVEDTSSSS EYGSVSPDDT ELKVDPFSFK 1090 1100 1110 1120 1130 1140 TRAKSCGERD VKGIRTLFLG IPDENFEDHS APPSPEEKDS GFFMLRKDSE RRATLHRILT 1150 1160 1170 1180 1190 1200 EDQDKIVRNL MESLAQGAEE PKLKWEHITT LIASLREFVR STDRKIIATT LSKLKLELDF 1210 1220 1230 1240 1250 1260 DSHGISQVQV VLFGFQDAVN KVLRNHNIKP HWMFALDSII RKAVQTAITI LVPELRPHFS 1270 1280 1290 1300 1310 1320 LASESDTADQ EDLDVEDDHE EQPSNQTVRR PQAVIEDAVA TSGVSTLSST VSHDSQSAHR 1330 1340 1350 1360 1370 1380 SLNVQLGRMK IETNRLLEEL VRKEKELQAL LHRAIEEKDQ EIKHLKLKSQ PIEIPELPVF 1390 1400 1410 1420 1430 1440 HLNSSGTNTE DSELTDWLRV NGADEDTISR FLAEDYTLLD VLYYVTRDDL KCLRLRGGML 1450 CTLWKAIIDF RNKQT

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92330.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209093 mRNA. Translation: BAD92330.1.
IPI	IPI00748581.
UniGene	Hs.186486.
3D structure databases
ProteinModelPortal	Q59GL6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59GL6.
PTM databases
PhosphoSite	Q59GL6.
Proteomic databases
PRIDE	Q59GL6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000293286.
HOVERGEN	HBG006305.
Gene expression databases
ArrayExpress	Q59GL6.
Family and domain databases
InterPro	IPR025136. DUF4071. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR013761. SAM/pointed. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF13281. DUF4071. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit. SSF47769. SAM_homology. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59GL6_HUMAN

Accession

Primary (citable) accession number: Q59GL6

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	October 3, 2012
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.