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Protein
Submitted name:

RAS p21 protein activator 1 isoform 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ59GK3.

Names & Taxonomyi

Protein namesi
Submitted name:
RAS p21 protein activator 1 isoform 1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ59GK3.

Expressioni

Gene expression databases

GenevisibleiQ59GK3. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000274376.

Structurei

3D structure databases

ProteinModelPortaliQ59GK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini214 – 30592SH2InterPro annotationAdd
BLAST
Domaini312 – 37463SH3InterPro annotationAdd
BLAST
Domaini384 – 47491SH2InterPro annotationAdd
BLAST
Domaini507 – 610104PHInterPro annotationAdd
BLAST
Domaini627 – 70983C2InterPro annotationAdd
BLAST
Domaini781 – 87191Ras-GAPInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3508. Eukaryota.
ENOG410XPU1. LUCA.
HOVERGENiHBG057470.
KOiK04352.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR028554. p120-RasGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10194:SF19. PTHR10194:SF19. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59GK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RGDASGWGCS EPGPGGPWGS RAGRVGQSRA GFNMMAAEAG SEEGGPVTAG
60 70 80 90 100
AGGGGAAAGS SAYPAVCRVK IPAALPVAAA PYPGLVETGV AGTLGGGAAL
110 120 130 140 150
GSEFLGAGSV AGALGGAGLT GGGTAAGVAG AAAGVAGAAV AGPSGDMALT
160 170 180 190 200
KLPTSLLAET LGPGGGFPPL PPPPYLPPLG AGLGTVDEGD SLDGPEYEEE
210 220 230 240 250
EVAIPLTAPP TNQWYHGKLD RTIAEERLRQ AGKSGSYLIR ESDRRPGSFV
260 270 280 290 300
LSFLSQMNVV NHFRIIAMCG DYYIGGRRFS SLSDLIGYYS HVSCLLKGEK
310 320 330 340 350
LLYPVAPPEP VEDRRRVRAI LPYTKVPDTD EISFLKGDMF IVHNELEDGW
360 370 380 390 400
MWVTNLRTDE QGLIVEDLVE EVGREEDPHE GKIWFHGKIS KQEAYNLLMT
410 420 430 440 450
VGQVCSFLVR PSDNTPGDYS LYFRTNENIQ RFKICPTPNN QFMMGGRYYN
460 470 480 490 500
SIGDIIDHYR KEQIVEGYYL KEPVPMQDQE QVLNDTVDGK EIYNTIRRKT
510 520 530 540 550
KDAFYKNIVK KGYLLKKGKG KRWKNLYFIL EGSDAQLIYF ESEKRATKPK
560 570 580 590 600
GLIDLSVCSV YVVHDSLFGR PNCFQIVVQH FSEEHYIFYF AGETPEQAED
610 620 630 640 650
WMKGLQAFCN LRKSSPGTSN KRLRQVSSLV LHIEEAHKLP VKHFTNPYCN
660 670 680 690 700
IYLNSVQVAK THAREGQNPV WSEEFVFDDL PPDINRFEIT LSNKTKKSKD
710 720 730 740 750
PDILFMRCQL SRLQKGHATD EWFLLSSHIP LKGIEPGSLR VRARYSMEKI
760 770 780 790 800
MPEEEYSEFK ELILQKELHV VYALSHVCGQ DRTLLASILL RIFLHEKLES
810 820 830 840 850
LLLCTLNDRE ISMEDEATTL FRATTLASTL MEQYMKATAT QFVHHALKDS
860 870
ILKIMESKQS CELSPSKLEK K
Length:871
Mass (Da):95,932
Last modified:April 26, 2005 - v1
Checksum:i0B12FCDD97F46FD3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209106 mRNA. Translation: BAD92343.1.
RefSeqiNP_002881.1. NM_002890.2.
UniGeneiHs.664080.

Genome annotation databases

GeneIDi5921.
KEGGihsa:5921.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209106 mRNA. Translation: BAD92343.1.
RefSeqiNP_002881.1. NM_002890.2.
UniGeneiHs.664080.

3D structure databases

ProteinModelPortaliQ59GK3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000274376.

Proteomic databases

PaxDbiQ59GK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5921.
KEGGihsa:5921.

Organism-specific databases

CTDi5921.

Phylogenomic databases

eggNOGiKOG3508. Eukaryota.
ENOG410XPU1. LUCA.
HOVERGENiHBG057470.
KOiK04352.

Enzyme and pathway databases

SignaLinkiQ59GK3.

Miscellaneous databases

GenomeRNAii5921.
NextBioi23056.

Gene expression databases

GenevisibleiQ59GK3. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR000008. C2_dom.
IPR028554. p120-RasGAP.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10194:SF19. PTHR10194:SF19. 1 hit.
PfamiPF00168. C2. 1 hit.
PF00169. PH. 1 hit.
PF00017. SH2. 2 hits.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
SMARTiSM00239. C2. 1 hit.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59GK3_HUMAN
AccessioniPrimary (citable) accession number: Q59GK3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.