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Protein
Submitted name:

RAS p21 protein activator 1 isoform 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ59GK3

Names & Taxonomyi

Protein namesi
Submitted name:
RAS p21 protein activator 1 isoform 1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiQ59GK3

Expressioni

Gene expression databases

GenevisibleiQ59GK3 HS

Structurei

3D structure databases

ProteinModelPortaliQ59GK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini214 – 305SH2InterPro annotationAdd BLAST92
Domaini312 – 374SH3InterPro annotationAdd BLAST63
Domaini384 – 474SH2InterPro annotationAdd BLAST91
Domaini507 – 610PHInterPro annotationAdd BLAST104
Domaini627 – 709C2InterPro annotationAdd BLAST83
Domaini781 – 871Ras-GAPInterPro annotationAdd BLAST91

Keywords - Domaini

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3508 Eukaryota
ENOG410XPU1 LUCA
HOVERGENiHBG057470
KOiK04352

Family and domain databases

CDDicd10354 SH2_Cterm_RasGAP, 1 hit
cd10353 SH2_Nterm_RasGAP, 1 hit
cd11788 SH3_RasGAP, 1 hit
Gene3Di2.30.29.301 hit
2.60.40.1501 hit
3.30.505.102 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028554 p120-RasGAP
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR035842 RasGAP_C_SH2
IPR001936 RasGAP_dom
IPR035841 RasGAP_N_SH2
IPR035652 RasGAP_SH3
IPR008936 Rho_GTPase_activation_prot
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PANTHERiPTHR10194:SF19 PTHR10194:SF19, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF00169 PH, 1 hit
PF00017 SH2, 2 hits
PF00018 SH3_1, 1 hit
PRINTSiPR00401 SH2DOMAIN
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SM00252 SH2, 2 hits
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS50001 SH2, 2 hits
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Fragment.

Q59GK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RGDASGWGCS EPGPGGPWGS RAGRVGQSRA GFNMMAAEAG SEEGGPVTAG
60 70 80 90 100
AGGGGAAAGS SAYPAVCRVK IPAALPVAAA PYPGLVETGV AGTLGGGAAL
110 120 130 140 150
GSEFLGAGSV AGALGGAGLT GGGTAAGVAG AAAGVAGAAV AGPSGDMALT
160 170 180 190 200
KLPTSLLAET LGPGGGFPPL PPPPYLPPLG AGLGTVDEGD SLDGPEYEEE
210 220 230 240 250
EVAIPLTAPP TNQWYHGKLD RTIAEERLRQ AGKSGSYLIR ESDRRPGSFV
260 270 280 290 300
LSFLSQMNVV NHFRIIAMCG DYYIGGRRFS SLSDLIGYYS HVSCLLKGEK
310 320 330 340 350
LLYPVAPPEP VEDRRRVRAI LPYTKVPDTD EISFLKGDMF IVHNELEDGW
360 370 380 390 400
MWVTNLRTDE QGLIVEDLVE EVGREEDPHE GKIWFHGKIS KQEAYNLLMT
410 420 430 440 450
VGQVCSFLVR PSDNTPGDYS LYFRTNENIQ RFKICPTPNN QFMMGGRYYN
460 470 480 490 500
SIGDIIDHYR KEQIVEGYYL KEPVPMQDQE QVLNDTVDGK EIYNTIRRKT
510 520 530 540 550
KDAFYKNIVK KGYLLKKGKG KRWKNLYFIL EGSDAQLIYF ESEKRATKPK
560 570 580 590 600
GLIDLSVCSV YVVHDSLFGR PNCFQIVVQH FSEEHYIFYF AGETPEQAED
610 620 630 640 650
WMKGLQAFCN LRKSSPGTSN KRLRQVSSLV LHIEEAHKLP VKHFTNPYCN
660 670 680 690 700
IYLNSVQVAK THAREGQNPV WSEEFVFDDL PPDINRFEIT LSNKTKKSKD
710 720 730 740 750
PDILFMRCQL SRLQKGHATD EWFLLSSHIP LKGIEPGSLR VRARYSMEKI
760 770 780 790 800
MPEEEYSEFK ELILQKELHV VYALSHVCGQ DRTLLASILL RIFLHEKLES
810 820 830 840 850
LLLCTLNDRE ISMEDEATTL FRATTLASTL MEQYMKATAT QFVHHALKDS
860 870
ILKIMESKQS CELSPSKLEK K
Length:871
Mass (Da):95,932
Last modified:April 26, 2005 - v1
Checksum:i0B12FCDD97F46FD3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209106 mRNA Translation: BAD92343.1
RefSeqiNP_002881.1, NM_002890.2
UniGeneiHs.664080

Genome annotation databases

GeneIDi5921
KEGGihsa:5921

Similar proteinsi

Entry informationi

Entry nameiQ59GK3_HUMAN
AccessioniPrimary (citable) accession number: Q59GK3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.