Unreviewed, UniProtKB/TrEMBL Q59GD8 (Q59GD8_HUMAN)

Names and origin

Protein names	Submitted name:     Calcium channel, voltage-dependent, L type, alpha 1D subunit variant EMBL BAD92408.1
Organism	Homo sapiens (Human) EMBL BAD92408.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1854 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein By similarity RuleBase RU003808V0.
Sequence similarities	Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Membrane
Domain	Transmembrane RuleBase RU003378V0
Ligand	Calcium
Molecular function	Calcium channel RuleBase RU003808V0 Ionic channel Voltage-gated channel RuleBase RU003808V0
Gene Ontology (GO)
Biological process	calcium ion transport Inferred from electronic annotation. Source: UniProtKB-KW transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular component	voltage-gated calcium channel complex Inferred from electronic annotation. Source: InterPro
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated calcium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92408.1

Sequences

	Sequence		Length	Mass (Da)
	Q59GD8-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 73DE6B07DF531A39	FASTA	1,854	211,464
	10 20 30 40 50 60 ANGTECRSGW VGPNGGITNF DNFAFAMLTV FQCITMEGWT DVLYWMNDAM GFELPWVYFV 70 80 90 100 110 120 SLVIFGSFFV LNLVLGVLSG EFSKEREKAK ARGDFQKLRE KQQLEEDLKG YLDWITQAED 130 140 150 160 170 180 IDPENEEEGG EEGKRNTSMP TSETESVNTE NVSGEGENRG CCGSLWCWWR RRGAAKAGPS 190 200 210 220 230 240 GCRRWGQAIS KSKLSRRWRR WNRFNRRRCR AAVKSVTFYW LVIVLVFLNT LTISSEHYNQ 250 260 270 280 290 300 PDWLTQIQDI ANKVLLALFT CEMLVKMYSL GLQAYFVSLF NRFDCFVVCG GITETILVEL 310 320 330 340 350 360 EIMSPLGISV FRCVRLLRIF KVTRHWTSLS NLVASLLNSM KSIASLLLLL FLFIIIFSLL 370 380 390 400 410 420 GMQLFGGKFN FDETQTKRST FDNFPQALLT VFQILTGEDW NAVMYDGIMA YGGPSSSGMI 430 440 450 460 470 480 VCIYFIILFI CGNYILLNVF LAIAVDNLAD AESLNTAQKE EAEEKERKKI ARKESLENKK 490 500 510 520 530 540 NNKPEVNQIA NSDNKVTIDD YREEDEDKDP YPPCDVPVGE EEEEEEEDEP EVPAGPRPRR 550 560 570 580 590 600 ISELNMKEKI APIPEGSAFF ILSKTNPIRV GCHKLINHHI FTNLILVFIM LSSAALAAED 610 620 630 640 650 660 PIRSHSFRNT ILGYFDYAFT AIFTVEILLK MTTFGAFLHK GAFCRNYFNL LDMLVVGVSL 670 680 690 700 710 720 VSFGIQSSAI SVVKILRVLR VLRPLRAINR AKGLKHVVQC VFVAIRTIGN IMIVTTLLQF 730 740 750 760 770 780 MFACIGVQLF KGKFYRCTDE AKSNPEECRG LFILYKDGDV DSPVVRERIW QNSDFNFDNV 790 800 810 820 830 840 LSAMMALFTV STFEGWPALL YKAIDSNGEN IGPIYNHRVE ISIFFIIYII IVAFFMMNIF 850 860 870 880 890 900 VGFVIVTFQE QGEKEYKNCE LDKNQRQCVE YALKARPLRR YIPKNPYQYK FWYVVNSSPF 910 920 930 940 950 960 EYMMFVLIML NTLCLAMQHY EQSKMFNDAM DILNMVFTGV FTVEMVLKVI AFKPKHYFTD 970 980 990 1000 1010 1020 AWNTFDALIV VGSVVDIAIT EVNPTESENV PVPTATPGNS EESNRISITF FRLFRVMRLV 1030 1040 1050 1060 1070 1080 KLLSRGEGIR TLLWTFIKSF QALPYVALLI AMLFFIYAVI GMQMFGKVAM RDNNQINRNN 1090 1100 1110 1120 1130 1140 NFQTFPQAVL LLFRCATGEA WQEIMLACLP GKLCDPESDY NPGEEYTCGS NFAIVYFISF 1150 1160 1170 1180 1190 1200 YMLCAFLIIN LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWSEYDPEAK GRIKHLDVVT 1210 1220 1230 1240 1250 1260 LLRRIQPPLG FGKLCPHRVA CKRLVAMNMP LNSDGTVMFN ATLFALVRTA LKIKTEGNLE 1270 1280 1290 1300 1310 1320 QANEELRAVI KKIWKKTSMK LLDQVVPPAG DDEVTVGKFY ATFLIQDYFR KFKKRKEQGL 1330 1340 1350 1360 1370 1380 VGKYPAKNTT IALQAGLRTL HDIGPEIRRA ISCDLQDDEP EETKREEEDD VFKRNGALLG 1390 1400 1410 1420 1430 1440 NHVNHVNSDR RDSLQQTNTT HRPLHVQRPS IPPASDTEKP LFPPAGNSVC HNHHNHNSIG 1450 1460 1470 1480 1490 1500 KQVPTSTNAN LNNANMSKAA HGKRPSIGNL EHVSENGHHS SHKHDREPQR RSSVKRTRYY 1510 1520 1530 1540 1550 1560 ETYIRSDSGD EQLPTICRED PEIHGYFRDP HCLGEQEYFS SEECYEDDSS PTWSRQNYGY 1570 1580 1590 1600 1610 1620 YSRYPGRNID SERPRGYHHP QGFLEDDDSP VCYDSRRSPR RRLLPPTPAS HRRSSFNFEC 1630 1640 1650 1660 1670 1680 LRRQSSQEEV PSSPIFPHRT ALPLHLMQQQ IMAVAGLDSS KAQKYSPSHS TRSWATPPAT 1690 1700 1710 1720 1730 1740 PPYRDWTPCY TPLIQVEQSE ALDQVNGSLP SLHRSSWYTD EPDISYRTFT PASLTVPSSF 1750 1760 1770 1780 1790 1800 RNKNSDKQRS ADSLVEAVLI SEGLGRYARD PKFVSATKHE IADACDLTID EMESAASTLL 1810 1820 1830 1840 1850 NGNVRPRANG DVGPLSHRQD YELQDFGPGY SDEEPDPGRD EEDLADEMIC ITTL

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92408.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209171 mRNA. Translation: BAD92408.1.
IPI	IPI00947531.
RefSeq	NP_000711.1. NP_001122312.1.
UniGene	Hs.476358
3D structure databases
SMR	Q59GD8. Positions 574-656, 892-1161, 1293-1321.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59GD8.
Genome annotation databases
Ensembl	ENST00000481478; ENSP00000418014; ENSG00000157388; Homo sapiens. [Genome view]
GeneID	776.
KEGG	hsa:776.
UCSC	uc003dgw.2. human.
Organism-specific databases
CTD	776.
HGNC	HGNC:1391. CACNA1D.
Phylogenomic databases
HOGENOM	HBG713873.
HOVERGEN	Q59GD8.
Gene expression databases
ArrayExpress	Q59GD8.
Bgee	Q59GD8.
Family and domain databases
InterPro	IPR005821. Ion_trans. IPR005452. LVDCC_a1dsu. IPR014873. VDCC_a1su_IQ. IPR002077. VDCCAlpha1. [Graphical view]
PANTHER	PTHR10037:SF48. LVDCCAlpha1D. 1 hit.
Pfam	PF08763. Ca_chan_IQ. 1 hit. PF00520. Ion_trans. 4 hits. [Graphical view]
PRINTS	PR00167. CACHANNEL. PR01636. LVDCCALPHA1D.
ProtoNet	Search...

Entry information

Entry name

Q59GD8_HUMAN

Accession

Primary (citable) accession number: Q59GD8

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	January 19, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.