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Protein
Submitted name:

Insulin-like growth factor 1 (Somatomedin C); insulin-like growth factor 1 (Somatomedia C) variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-like growth factor 1 (Somatomedin C); insulin-like growth factor 1 (Somatomedia C) variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29697.

Protein family/group databases

Allergomei11751. Hom s IGF-1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500425248822 – 184Sequence analysisAdd BLAST163

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ59GC5.
PeptideAtlasiQ59GC5.
PRIDEiQ59GC5.

Expressioni

Gene expression databases

GenevisibleiQ59GC5. HS.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 140IlGFInterPro annotationAdd BLAST59

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ2T. Eukaryota.
ENOG4111MIV. LUCA.
HOGENOMiHOG000233362.
HOVERGENiHBG006137.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR022341. IGF-I.
IPR016179. Insulin-like.
IPR022350. Insulin-like_growth_factor.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF00049. Insulin. 1 hit.
PRINTSiPR02002. INSLNLIKEGF.
PR02005. INSLNLIKEGF1.
PR00276. INSULINFAMLY.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59GC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
HCSQHLPSLW ISFCFIIPAN QFIFRLCTSE AMGKISSLPT QLFKCCFCDF
60 70 80 90 100
LKVKMHTMSS SHLFYLALCL LTFTSSATAG PETLCGAELV DALQFVCGDR
110 120 130 140 150
GFYFNKPTGY GSSSRRAPQT GIVDECCFRS CDLRRLEMYC APLKPAKSAR
160 170 180
SVRAQRHTDM PKTQKEVHLK NASRGSAGNK NYRM
Length:184
Mass (Da):20,618
Last modified:April 26, 2005 - v1
Checksum:i3B94B8DA4033D63A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209184 mRNA. Translation: BAD92421.1.
RefSeqiNP_000609.1. NM_000618.4.
UniGeneiHs.160562.

Genome annotation databases

GeneIDi3479.

Similar proteinsi

Entry informationi

Entry nameiQ59GC5_HUMAN
AccessioniPrimary (citable) accession number: Q59GC5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 27, 2017
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.