ID   Q59G42_HUMAN            Unreviewed;       940 AA.
AC   Q59G42;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   27-MAR-2024, entry version 87.
DE   RecName: Full=Eukaryotic translation initiation factor 4 gamma 2 {ECO:0000256|ARBA:ARBA00040449};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92504.1};
RN   [1] {ECO:0000313|EMBL:BAD92504.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAD92504.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Appears to play a role in the switch from cap-dependent to
CC       IRES-mediated translation during mitosis, apoptosis and viral
CC       infection. Cleaved by some caspases and viral proteases.
CC       {ECO:0000256|ARBA:ARBA00037759}.
CC   -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC       {ECO:0000256|ARBA:ARBA00005775}.
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DR   EMBL; AB209267; BAD92504.1; -; mRNA.
DR   AlphaFoldDB; Q59G42; -.
DR   PeptideAtlas; Q59G42; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR   CDD; cd11559; W2_eIF4G1_like; 1.
DR   Gene3D; 1.25.40.180; -; 3.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR045208; IF4G.
DR   InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR   InterPro; IPR003890; MIF4G-like_typ-3.
DR   InterPro; IPR003307; W2_domain.
DR   PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR   PANTHER; PTHR23253:SF82; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2; 1.
DR   Pfam; PF02847; MA3; 1.
DR   Pfam; PF02854; MIF4G; 1.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SMART; SM00544; MA3; 1.
DR   SMART; SM00543; MIF4G; 1.
DR   SUPFAM; SSF48371; ARM repeat; 3.
DR   PROSITE; PS51366; MI; 1.
DR   PROSITE; PS51363; W2; 1.
PE   2: Evidence at transcript level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Initiation factor {ECO:0000313|EMBL:BAD92504.1};
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Protein biosynthesis {ECO:0000313|EMBL:BAD92504.1};
KW   Repressor {ECO:0000256|ARBA:ARBA00022491};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          576..699
FT                   /note="MI"
FT                   /evidence="ECO:0000259|PROSITE:PS51366"
FT   DOMAIN          753..937
FT                   /note="W2"
FT                   /evidence="ECO:0000259|PROSITE:PS51363"
FT   REGION          44..104
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          531..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..96
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92504.1"
SQ   SEQUENCE   940 AA;  105828 MW;  56DB1027B537D9FD CRC64;
     VLGEGISFLL SPPLPTPSIN IILLKILRCQ AAKVESAIAE GGASRFSASS GGGGSRGAPQ
     HYPKTAGNSE FLGKTPGQNA QKWIPARSTR RDDNSAANNS ANEKERHDAI FRKVRGILNK
     LTPEKFDKLC LELLNVGVES KLILKGVILL IVDKALEEPK YSSLYAQLCL RLAEDAPNFD
     GPAAEGQPGQ KQSTTFRRLL ISKLQDEFEN RTRNVDVYDK RENPLLPEEE EQRAIAKIKM
     LGNIKFIGEL GKLDLIHESI LHKCIKTLLE KKKRVQLKDM GEDLECLCQI MRTVGPRLDH
     ERAKSLMDQY FARMCSLMLS KELPARIRFL LQDTVELREH HWVPRKAFLD NGPKTINQIR
     QDAVKDLGVF IPAPMAQGMR SDFFLEGPFM PPRMKMDRDP LGGLADMFGQ MPGSGIGTGP
     GVIQDRFSPT MGRHRSNQLF NGHGGHIMPP TQSQFGEMGG KFMKSQGLSQ LYHNQSQGLL
     SQLQGQSKDM PPRFSKKGQL NADEISLRPA QSFLMNKNQV PKLQPQITMI PPSAQPPRTQ
     TPPLGQTPQL GLKTNPPLIQ EKPAKTSKKP PPSKEELLKL TETVVTEYLN SGNANEAVNG
     VREMRAPKHF LPEMLSKVII LSLDRSDEDK EKASSLISLL KQEGIATSDN FMQAFLNVLD
     QCPKLEVDIP LVKSYLAQFA ARAIISELVS ISELAQPLES GTHFPLFLLC LQQLAKLQDR
     EWLTELFQQS KVNMQKMLPE IDQNKDRMLE ILEGKGLSFL FPLLKLEKEL LKQIKLDPSP
     QTIYKWIKDN ISPKLHVDKG FVNILMTSFL QYISSEVNPP SDETDSSSAP SKEQLEQEKQ
     LLLSFKPVMQ KFLHDHVDLQ VSALYALQVH CYNSNFPKGM LLRFFVHFYD MEIIEEEAFL
     AWKEDITQEF PGKGKALFQV NQWLTWLETA EEEESEEEAD
//