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Q59FY4

- Q59FY4_HUMAN

UniProt

Q59FY4 - Q59FY4_HUMAN

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Protein
Submitted name: Acetyl-CoA carboxylase 1
Gene
ACACA
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. acetyl-CoA carboxylase activity Source: InterPro

GO - Biological processi

  1. fatty acid biosynthetic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Acetyl-CoA carboxylase 1Imported
Submitted name:
Acetyl-Coenzyme A carboxylase alpha isoform 2 variantImported
Gene namesi
Name:ACACAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:84. ACACA.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG086472.

Family and domain databases

Gene3Di3.90.226.10. 3 hits.
InterProiIPR013537. AcCoA_COase_cen.
IPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF08326. ACC_central. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.
PROSITEiPS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59FY4-1 [UniParc]FASTAAdd to Basket

« Hide

EDDRLAAMFR EFTQQNKATL VDHGIRRLTF LVAQKDFRKQ VNYEVDRRFH    50
REFPKFFTFR ARDKFEEDRI YRHLEPALAF QLELNRMRNF DLTAIPCANH 100
KMHLYLGAAK VEVGTEVTDY RFFVRAIIRH SDLVTKEASF EYLQNEGERL 150
LLEAMDELEV AFNNTNVRTD CNHIFLNFVP TVIMDPSKIE ESVRSMVMRY 200
GSRLWKLRVL QAELKINIRL TPTGKAIPIR LFLTNESGYY LDISLYKEVT 250
DSRTAQIMFQ AYGDKQGPLH GMLINTPYVT KDLLQSKRFQ AQSLGTTYIY 300
DIPEMFRQIG MVAWKMTFKS PEYPEGRDII VIGNDITYRI GSFGPQEDLL 350
FLRASELARA EGIPRIYVSA NSGARIGLAE EIRHMFHVAW VDPEDPYKGY 400
RYLYLTPQDY KRVSALNSVH CEHVEDEGES RYKITDIIGK EEGIGPENLR 450
GSGMIAGESS LAYNEIITIS LVTCRAIGIG AYLVRLGQRT IQVENSHLIL 500
TGAGALNKVL GREVYTSNNQ LGGIQIMHNN GVTHCTVCDD FEGVFTVLHW 550
LSYMPKSVHS SVPLLNSKDP IDRIIEFVPT KTPYDPRWML AGRPHPTQKG 600
QWLSGFFDYG SFSEIMQPWA QTVVVGRARL GGIPVGVVAV ETRTVELSIP 650
ADPANLDSEA KIIQQAGQVW FPDSAFKTYQ AIKDFNREGL PLMVFANWRG 700
FSGGMKDMYD QVLKFGAYIV DGLRECCQPV LVYIPPQAEL RGGSWVVIDS 750
SINPRHMEMY ADRESRGSVL EPEGTVEIKF RRKDLVKTMR RVDPVYIHLA 800
ERLGTPELST AERKELENKL KEREEFLIPI YHQVAVQFAD LHDTPGRMQE 850
KGVISDILDW KTSRTFFYWR LRRLLLEDLV KKKIHNANPE LTDGQIQAML 900
RRWFVEVEGT VKAYVWDNNK DLAEWLEKQL TEEDGVHSVI EENIKCISRD 950
YVLKQIRSLV QANPEVAMDS IIHMTQHISP TQRAEVIRIL STMDSPST 998
Length:998
Mass (Da):114,618
Last modified:April 26, 2005 - v1
Checksum:i78A0767D8144A97C
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC003103 Genomic DNA. No translation available.
AC016482 Genomic DNA. No translation available.
AC068400 Genomic DNA. No translation available.
AB209325 mRNA. Translation: BAD92562.1.
UniGeneiHs.160556.

Genome annotation databases

EnsembliENST00000591119; ENSP00000467820; ENSG00000132142.
UCSCiuc010cuy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC003103 Genomic DNA. No translation available.
AC016482 Genomic DNA. No translation available.
AC068400 Genomic DNA. No translation available.
AB209325 mRNA. Translation: BAD92562.1 .
UniGenei Hs.160556.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000591119 ; ENSP00000467820 ; ENSG00000132142 .
UCSCi uc010cuy.3. human.

Organism-specific databases

HGNCi HGNC:84. ACACA.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG086472.

Family and domain databases

Gene3Di 3.90.226.10. 3 hits.
InterProi IPR013537. AcCoA_COase_cen.
IPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011763. COA_CT_C.
IPR011762. COA_CT_N.
[Graphical view ]
Pfami PF08326. ACC_central. 1 hit.
PF01039. Carboxyl_trans. 1 hit.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 2 hits.
PROSITEi PS50989. COA_CT_CTER. 1 hit.
PS50980. COA_CT_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (NOV-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ59FY4_HUMAN
AccessioniPrimary (citable) accession number: Q59FY4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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