ID   Q59FY1_HUMAN            Unreviewed;       917 AA.
AC   Q59FY1;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   08-NOV-2023, entry version 125.
DE   SubName: Full=Synapse-associated protein 102 variant {ECO:0000313|EMBL:BAD92565.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92565.1};
RN   [1] {ECO:0000313|EMBL:BAD92565.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:BAD92565.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AB209328; BAD92565.1; -; mRNA.
DR   RefSeq; NP_066943.2; NM_021120.3.
DR   AlphaFoldDB; Q59FY1; -.
DR   DNASU; 1741; -.
DR   GeneID; 1741; -.
DR   KEGG; hsa:1741; -.
DR   CTD; 1741; -.
DR   PharmGKB; PA164741439; -.
DR   OrthoDB; 2879721at2759; -.
DR   BioGRID-ORCS; 1741; 9 hits in 779 CRISPR screens.
DR   GenomeRNAi; 1741; -.
DR   GO; GO:0031594; C:neuromuscular junction; IEA:InterPro.
DR   GO; GO:0043005; C:neuron projection; IEA:InterPro.
DR   GO; GO:0019900; F:kinase binding; IEA:InterPro.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR   CDD; cd00071; GMPK; 1.
DR   CDD; cd00992; PDZ_signaling; 3.
DR   CDD; cd12029; SH3_DLG3; 1.
DR   Gene3D; 2.30.42.10; -; 3.
DR   Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR019583; DLG1-4_PDZ_assoc.
DR   InterPro; IPR016313; DLG1-like.
DR   InterPro; IPR019590; DLG1_PEST_dom.
DR   InterPro; IPR035763; DLG3_SH3.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR23119; DISCS LARGE; 1.
DR   PANTHER; PTHR23119:SF28; DISKS LARGE HOMOLOG 3; 1.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF00595; PDZ; 3.
DR   Pfam; PF10600; PDZ_assoc; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   PIRSF; PIRSF001741; MAGUK_DLGH; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM01277; MAGUK_N_PEST; 1.
DR   SMART; SM00228; PDZ; 3.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 3.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 3.
DR   PROSITE; PS50002; SH3; 1.
DR   Genevisible; Q59FY1; HS.
PE   2: Evidence at transcript level;
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          231..318
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          326..413
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          486..567
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          601..671
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   DOMAIN          727..902
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50052"
FT   REGION          1..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..60
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92565.1"
SQ   SEQUENCE   917 AA;  99796 MW;  DFF5EAD57A2C1196 CRC64;
     APASSLPLGL GPEATTGDTE PPVLEGEPWV RGSVGAEAPG RPPGPRPRSA RAPPRVPPPS
     WSEQCECARE PGGGGGGGGG GGGGVESGVG WGVRAAGGSA MHKHQHCCKC PECYEVTRLA
     ALRRLEPPGY GDWQVPDPYG PGGGNGASAG YGGYSSQTLP SQAGATPTPR TKAKLIPTGR
     DVGPVPPKPV PGKSTPKLNG SGPSWWPECT CTNRDWYEQV NGSDGMFKYE EIVLERGNSG
     LGFSIAGGID NPHVPDDPGI FITKIIPGGA AAMDGRLGVN DCVLRVNEVD VSEVVHSRAV
     EALKEAGPVV RLVVRRRQPP PETIMEVNLL KGPKGLGFSI AGGIGNQHIP GDNSIYITKI
     IEGGAAQKDG RLQIGDRLLA VNNTNLQDVR HEEAVASLKN TSDMVYLKVA KPGSLHLNDM
     YAPPDYASTF TALADNHISH NSSLGYLGAV ESKVSYPAPP QVPPTRYSPI PRHMLAEEDF
     TREPRKIILH KGSTGLGFNI VGGEDGEGIF VSFILAGGPA DLSGELRRGD RILSVNGVNL
     RNATHEQAAA ALKRAGQSVT IVAQYRPEEY SRFESKIHDL REQMMNSSMS SGSGSLRTSE
     KRSLYVRALF DYDRTRDSCL PSQGLSFSYG DILHVINASD DEWWQARLVT PHGESEQIGV
     IPSKKRVEKK ERARLKTVKF HARTGMIESN RDFPGLSDDY YGAKNLKGQE DAILSYEPVT
     RQEIHYARPV IILGPMKDRV NDDLISEFPH KFGSCVPHTT RPRRDNEVDG QDYHFVVSRE
     QMEKDIQDNK FIEAGQFNDN LYGTSIQSVR AVAERGKHCI LDVSGNAIKR LQQAQLYPIA
     IFIKPKSIEA LMEMNRRQTY EQANKIYDKA MKLEQEFGEY FTAIVQGDSL EEIYNKIKQI
     IEDQSGHYIW VPSPEKL
//