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Protein

Non-specific protein-tyrosine kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: Ensembl
  3. manganese ion binding Source: Ensembl
  4. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. actin filament branching Source: Ensembl
  2. activated T cell proliferation Source: Ensembl
  3. alpha-beta T cell differentiation Source: Ensembl
  4. B-1 B cell homeostasis Source: Ensembl
  5. B cell proliferation involved in immune response Source: Ensembl
  6. B cell receptor signaling pathway Source: Ensembl
  7. Bergmann glial cell differentiation Source: Ensembl
  8. cellular response to lipopolysaccharide Source: Ensembl
  9. cerebellum morphogenesis Source: Ensembl
  10. collateral sprouting Source: Ensembl
  11. epidermal growth factor receptor signaling pathway Source: Ensembl
  12. microspike assembly Source: Ensembl
  13. negative regulation of BMP signaling pathway Source: Ensembl
  14. negative regulation of cell-cell adhesion Source: Ensembl
  15. negative regulation of cellular senescence Source: Ensembl
  16. negative regulation of endothelial cell apoptotic process Source: Ensembl
  17. negative regulation of ERK1 and ERK2 cascade Source: Ensembl
  18. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  19. negative regulation of mitotic cell cycle Source: Ensembl
  20. neuromuscular process controlling balance Source: Ensembl
  21. phagocytosis Source: Ensembl
  22. platelet-derived growth factor receptor signaling pathway Source: Ensembl
  23. positive regulation of apoptotic process Source: Ensembl
  24. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  25. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  26. positive regulation of interferon-gamma secretion Source: Ensembl
  27. positive regulation of interleukin-2 secretion Source: Ensembl
  28. positive regulation of mitotic cell cycle Source: Ensembl
  29. positive regulation of neuron death Source: Ensembl
  30. positive regulation of osteoblast proliferation Source: Ensembl
  31. positive regulation of release of sequestered calcium ion into cytosol Source: Ensembl
  32. positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
  33. regulation of actin cytoskeleton organization Source: Ensembl
  34. regulation of extracellular matrix organization Source: Ensembl
  35. response to oxidative stress Source: Ensembl
  36. spleen development Source: Ensembl
  37. substrate adhesion-dependent cell spreading Source: Ensembl
  38. thymus development Source: Ensembl
  39. transitional one stage B cell differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ59FK4.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific protein-tyrosine kinaseSAAS annotation (EC:2.7.10.2SAAS annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. cell leading edge Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. nucleoplasm Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24413.

PTM / Processingi

Proteomic databases

PRIDEiQ59FK4.

Expressioni

Gene expression databases

BgeeiQ59FK4.
ExpressionAtlasiQ59FK4. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ59FK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG004162.
KOiK06619.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59FK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PFWKILNPLL ERGTYYYFMG QQPGKVLGDQ RRPSLPALHF IKGAGKKESS
60 70 80 90 100
RHGGPHCNVF VEHEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP
110 120 130 140 150
NLFVALYDFV ASGDNTLSIT KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS
160 170 180 190 200
NYITPVNSLE KHSWYHGPVS RNAAEYLLSS GINGSFLVRE SESSPGQRSI
210 220 230 240 250
SLRYEGRVYH YRINTASDGK LYVSSESRFN TLAELVHHHS TVADGLITTL
260 270 280 290 300
HYPAPKRNKP TVYGVSPNYD KWEMERTDIT MKHKLGGGQY GEVYEGVWKK
310 320 330 340 350
YSLTVAVKTL KEDTMEVEEF LKEAAVMKEI KHPNLVQLLG VCTREPPFYI
360 370 380 390 400
ITEFMTYGNL LDYLRECNRQ EVNAVVLLYM ATQISSAMEY LEKKNFIHRD
410 420 430 440 450
LAARNCLVGE NHLVKVADFG LSRLMTGDTY TAHAGAKFPI KWTAPESLAY
460 470 480 490 500
NKFSIKSDVW AFGVLLWEIA TYGMSPYPGI DLSQVYELLE KDYRMERPEG
510 520 530 540 550
CPEKVYELMR ACWQWNPSDR PSFAEIHQAF ETMFQESSIS DEVEKELGKQ
560 570 580 590 600
GVRGAVSTLL QAPELPTKTR TSRRAAEHRD TTDVPEMPHS KGQGESDPLD
610 620 630 640 650
HEPAVSPLLP RKERGPPEGG LNEDERLLPK DKKTNLFSAL IKKKKKTAPT
660 670 680 690 700
PPKRSSSFRE MDGQPERRGA GEEEGRDISN GALAFTPLDT ADPAKSPKPS
710 720 730 740 750
NGAGVPNGAL RESGGSGFRS PHLWKKSSTL TSSRLATGEE EGGGSSSKRF
760 770 780 790 800
LRSCSASCVP HGAKDTEWRS VTLPRDLQST GRQFDSSTFG GHKSEKPALP
810 820 830 840 850
RKRAGENRSD QVTRGTVTPP PRLVKKNEEA ADEVFKDIME SSPGSSPPNL
860 870 880 890 900
TPKPLRRQVT VAPASGLPHK EEAGKGSALG TPAAAEPVTP TSKAGSGAPG
910 920 930 940 950
GTSKGPAEES RVRRHKHSSE SPGRDKGKLS RLKPAPPPPP AASAGKAGGK
960 970 980 990 1000
PSQSPSQEAA GEAVLGAKTK ATSLVDAVNS DAAKPSQPGE GLKKPVLPAT
1010 1020 1030 1040 1050
PKPQSAKPSG TPISPAPVPS TLPSASSALA GDQPSSTAFI PLISTRVSLR
1060 1070 1080 1090 1100
KTRQPPERIA SGAITKGVVL DSTEALCLAI SRNSEQMASH SAVLEAGKNL
1110 1120 1130 1140 1150
YTFCVSYVDS IQQMRNKFAF REAINKLENN LRELQICPAT AGSGPAATQD
1160
FSKLLSSVKE ISDIVQR
Length:1,167
Mass (Da):127,257
Last modified:April 25, 2005 - v1
Checksum:iF05C6B7355BE8945
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209456 mRNA. Translation: BAD92693.1.
RefSeqiNP_005148.2. NM_005157.5.
NP_009297.2. NM_007313.2.
UniGeneiHs.431048.

Genome annotation databases

GeneIDi25.
KEGGihsa:25.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209456 mRNA. Translation: BAD92693.1.
RefSeqiNP_005148.2. NM_005157.5.
NP_009297.2. NM_007313.2.
UniGeneiHs.431048.

3D structure databases

ProteinModelPortaliQ59FK4.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ59FK4.

Proteomic databases

PRIDEiQ59FK4.

Protocols and materials databases

DNASUi25.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25.
KEGGihsa:25.

Organism-specific databases

CTDi25.
H-InvDBHIX0008474.
PharmGKBiPA24413.

Phylogenomic databases

HOVERGENiHBG004162.
KOiK06619.

Enzyme and pathway databases

SignaLinkiQ59FK4.

Miscellaneous databases

GenomeRNAii25.
NextBioi79.

Gene expression databases

BgeeiQ59FK4.
ExpressionAtlasiQ59FK4. baseline and differential.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59FK4_HUMAN
AccessioniPrimary (citable) accession number: Q59FK4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 25, 2005
Last sequence update: April 25, 2005
Last modified: March 3, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.