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Q59FK4 (Q59FK4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
OrganismHomo sapiens (Human) EMBL BAD92693.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1167 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS000980

Sequence similarities

Contains 1 SH2 domain.

Contains 1 SH3 domain. RuleBase RU003338

Contains SH2 domain. SAAS SAAS000980

Contains SH3 domain. SAAS SAAS000980

Contains SHdomain. SAAS SAAS000980

Contains protein kinase domain. SAAS SAAS000980

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL BAD92693.1

Sequences

Sequence LengthMass (Da)Tools
Q59FK4 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: F05C6B7355BE8945

FASTA1,167127,257
        10         20         30         40         50         60 
PFWKILNPLL ERGTYYYFMG QQPGKVLGDQ RRPSLPALHF IKGAGKKESS RHGGPHCNVF 

        70         80         90        100        110        120 
VEHEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP NLFVALYDFV ASGDNTLSIT 

       130        140        150        160        170        180 
KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS NYITPVNSLE KHSWYHGPVS RNAAEYLLSS 

       190        200        210        220        230        240 
GINGSFLVRE SESSPGQRSI SLRYEGRVYH YRINTASDGK LYVSSESRFN TLAELVHHHS 

       250        260        270        280        290        300 
TVADGLITTL HYPAPKRNKP TVYGVSPNYD KWEMERTDIT MKHKLGGGQY GEVYEGVWKK 

       310        320        330        340        350        360 
YSLTVAVKTL KEDTMEVEEF LKEAAVMKEI KHPNLVQLLG VCTREPPFYI ITEFMTYGNL 

       370        380        390        400        410        420 
LDYLRECNRQ EVNAVVLLYM ATQISSAMEY LEKKNFIHRD LAARNCLVGE NHLVKVADFG 

       430        440        450        460        470        480 
LSRLMTGDTY TAHAGAKFPI KWTAPESLAY NKFSIKSDVW AFGVLLWEIA TYGMSPYPGI 

       490        500        510        520        530        540 
DLSQVYELLE KDYRMERPEG CPEKVYELMR ACWQWNPSDR PSFAEIHQAF ETMFQESSIS 

       550        560        570        580        590        600 
DEVEKELGKQ GVRGAVSTLL QAPELPTKTR TSRRAAEHRD TTDVPEMPHS KGQGESDPLD 

       610        620        630        640        650        660 
HEPAVSPLLP RKERGPPEGG LNEDERLLPK DKKTNLFSAL IKKKKKTAPT PPKRSSSFRE 

       670        680        690        700        710        720 
MDGQPERRGA GEEEGRDISN GALAFTPLDT ADPAKSPKPS NGAGVPNGAL RESGGSGFRS 

       730        740        750        760        770        780 
PHLWKKSSTL TSSRLATGEE EGGGSSSKRF LRSCSASCVP HGAKDTEWRS VTLPRDLQST 

       790        800        810        820        830        840 
GRQFDSSTFG GHKSEKPALP RKRAGENRSD QVTRGTVTPP PRLVKKNEEA ADEVFKDIME 

       850        860        870        880        890        900 
SSPGSSPPNL TPKPLRRQVT VAPASGLPHK EEAGKGSALG TPAAAEPVTP TSKAGSGAPG 

       910        920        930        940        950        960 
GTSKGPAEES RVRRHKHSSE SPGRDKGKLS RLKPAPPPPP AASAGKAGGK PSQSPSQEAA 

       970        980        990       1000       1010       1020 
GEAVLGAKTK ATSLVDAVNS DAAKPSQPGE GLKKPVLPAT PKPQSAKPSG TPISPAPVPS 

      1030       1040       1050       1060       1070       1080 
TLPSASSALA GDQPSSTAFI PLISTRVSLR KTRQPPERIA SGAITKGVVL DSTEALCLAI 

      1090       1100       1110       1120       1130       1140 
SRNSEQMASH SAVLEAGKNL YTFCVSYVDS IQQMRNKFAF REAINKLENN LRELQICPAT 

      1150       1160 
AGSGPAATQD FSKLLSSVKE ISDIVQR 

« Hide

References

[1]"Homo sapiens protein coding cDNA."
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain EMBL BAD92693.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB209456 mRNA. Translation: BAD92693.1.
RefSeqNP_005148.2. NM_005157.4.
NP_009297.2. NM_007313.2.
UniGeneHs.431048.

3D structure databases

ProteinModelPortalQ59FK4.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ59FK4.

Proteomic databases

PRIDEQ59FK4.

Protocols and materials databases

DNASU25.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25.
KEGGhsa:25.

Organism-specific databases

CTD25.
H-InvDBHIX0008474.
PharmGKBPA24413.

Phylogenomic databases

HOVERGENHBG004162.
KOK06619.

Enzyme and pathway databases

SignaLinkQ59FK4.

Gene expression databases

ArrayExpressQ59FK4.
BgeeQ59FK4.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi25.
NextBio79.

Entry information

Entry nameQ59FK4_HUMAN
AccessionPrimary (citable) accession number: Q59FK4
Entry history
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.