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Protein

Non-specific protein-tyrosine kinase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ59FK4.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific protein-tyrosine kinaseSAAS annotation (EC:2.7.10.2SAAS annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24413.

PTM / Processingi

Proteomic databases

PRIDEiQ59FK4.

Expressioni

Gene expression databases

BgeeiQ59FK4.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ59FK4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

HOVERGENiHBG004162.
KOiK06619.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59FK4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PFWKILNPLL ERGTYYYFMG QQPGKVLGDQ RRPSLPALHF IKGAGKKESS
60 70 80 90 100
RHGGPHCNVF VEHEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP
110 120 130 140 150
NLFVALYDFV ASGDNTLSIT KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS
160 170 180 190 200
NYITPVNSLE KHSWYHGPVS RNAAEYLLSS GINGSFLVRE SESSPGQRSI
210 220 230 240 250
SLRYEGRVYH YRINTASDGK LYVSSESRFN TLAELVHHHS TVADGLITTL
260 270 280 290 300
HYPAPKRNKP TVYGVSPNYD KWEMERTDIT MKHKLGGGQY GEVYEGVWKK
310 320 330 340 350
YSLTVAVKTL KEDTMEVEEF LKEAAVMKEI KHPNLVQLLG VCTREPPFYI
360 370 380 390 400
ITEFMTYGNL LDYLRECNRQ EVNAVVLLYM ATQISSAMEY LEKKNFIHRD
410 420 430 440 450
LAARNCLVGE NHLVKVADFG LSRLMTGDTY TAHAGAKFPI KWTAPESLAY
460 470 480 490 500
NKFSIKSDVW AFGVLLWEIA TYGMSPYPGI DLSQVYELLE KDYRMERPEG
510 520 530 540 550
CPEKVYELMR ACWQWNPSDR PSFAEIHQAF ETMFQESSIS DEVEKELGKQ
560 570 580 590 600
GVRGAVSTLL QAPELPTKTR TSRRAAEHRD TTDVPEMPHS KGQGESDPLD
610 620 630 640 650
HEPAVSPLLP RKERGPPEGG LNEDERLLPK DKKTNLFSAL IKKKKKTAPT
660 670 680 690 700
PPKRSSSFRE MDGQPERRGA GEEEGRDISN GALAFTPLDT ADPAKSPKPS
710 720 730 740 750
NGAGVPNGAL RESGGSGFRS PHLWKKSSTL TSSRLATGEE EGGGSSSKRF
760 770 780 790 800
LRSCSASCVP HGAKDTEWRS VTLPRDLQST GRQFDSSTFG GHKSEKPALP
810 820 830 840 850
RKRAGENRSD QVTRGTVTPP PRLVKKNEEA ADEVFKDIME SSPGSSPPNL
860 870 880 890 900
TPKPLRRQVT VAPASGLPHK EEAGKGSALG TPAAAEPVTP TSKAGSGAPG
910 920 930 940 950
GTSKGPAEES RVRRHKHSSE SPGRDKGKLS RLKPAPPPPP AASAGKAGGK
960 970 980 990 1000
PSQSPSQEAA GEAVLGAKTK ATSLVDAVNS DAAKPSQPGE GLKKPVLPAT
1010 1020 1030 1040 1050
PKPQSAKPSG TPISPAPVPS TLPSASSALA GDQPSSTAFI PLISTRVSLR
1060 1070 1080 1090 1100
KTRQPPERIA SGAITKGVVL DSTEALCLAI SRNSEQMASH SAVLEAGKNL
1110 1120 1130 1140 1150
YTFCVSYVDS IQQMRNKFAF REAINKLENN LRELQICPAT AGSGPAATQD
1160
FSKLLSSVKE ISDIVQR
Length:1,167
Mass (Da):127,257
Last modified:April 26, 2005 - v1
Checksum:iF05C6B7355BE8945
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209456 mRNA. Translation: BAD92693.1.
RefSeqiNP_005148.2. NM_005157.5.
NP_009297.2. NM_007313.2.
UniGeneiHs.431048.

Genome annotation databases

GeneIDi25.
KEGGihsa:25.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209456 mRNA. Translation: BAD92693.1.
RefSeqiNP_005148.2. NM_005157.5.
NP_009297.2. NM_007313.2.
UniGeneiHs.431048.

3D structure databases

ProteinModelPortaliQ59FK4.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ59FK4.

Proteomic databases

PRIDEiQ59FK4.

Protocols and materials databases

DNASUi25.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25.
KEGGihsa:25.

Organism-specific databases

CTDi25.
H-InvDBHIX0008474.
PharmGKBiPA24413.

Phylogenomic databases

HOVERGENiHBG004162.
KOiK06619.

Enzyme and pathway databases

SignaLinkiQ59FK4.

Miscellaneous databases

GenomeRNAii25.
NextBioi79.

Gene expression databases

BgeeiQ59FK4.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59FK4_HUMAN
AccessioniPrimary (citable) accession number: Q59FK4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 27, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.