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Q59FK4

- Q59FK4_HUMAN

UniProt

Q59FK4 - Q59FK4_HUMAN

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Protein
Submitted name: V-abl Abelson murine leukemia viral oncogene homolog 1 isoform b variant
Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotations

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: Ensembl
  3. manganese ion binding Source: Ensembl
  4. non-membrane spanning protein tyrosine kinase activity Source: InterPro

GO - Biological processi

  1. actin cytoskeleton organization Source: Ensembl
  2. platelet-derived growth factor receptor signaling pathway Source: Ensembl
  3. regulation of cell cycle Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinaseSAAS annotations

Keywords - Ligandi

ATP-bindingSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ59FK4.

Names & Taxonomyi

Protein namesi
Submitted name:
V-abl Abelson murine leukemia viral oncogene homolog 1 isoform b variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cell leading edge Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. nucleus Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24413.

PTM / Processingi

Proteomic databases

PRIDEiQ59FK4.

Expressioni

Gene expression databases

ArrayExpressiQ59FK4.
BgeeiQ59FK4.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ59FK4.

Family & Domainsi

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.UniRule annotation
Contains SH3 domain.SAAS annotations
Contains SHdomain.SAAS annotations

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotations

Phylogenomic databases

HOVERGENiHBG004162.
KOiK06619.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59FK4-1 [UniParc]FASTAAdd to Basket

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PFWKILNPLL ERGTYYYFMG QQPGKVLGDQ RRPSLPALHF IKGAGKKESS     50
RHGGPHCNVF VEHEALQRPV ASDFEPQGLS EAARWNSKEN LLAGPSENDP 100
NLFVALYDFV ASGDNTLSIT KGEKLRVLGY NHNGEWCEAQ TKNGQGWVPS 150
NYITPVNSLE KHSWYHGPVS RNAAEYLLSS GINGSFLVRE SESSPGQRSI 200
SLRYEGRVYH YRINTASDGK LYVSSESRFN TLAELVHHHS TVADGLITTL 250
HYPAPKRNKP TVYGVSPNYD KWEMERTDIT MKHKLGGGQY GEVYEGVWKK 300
YSLTVAVKTL KEDTMEVEEF LKEAAVMKEI KHPNLVQLLG VCTREPPFYI 350
ITEFMTYGNL LDYLRECNRQ EVNAVVLLYM ATQISSAMEY LEKKNFIHRD 400
LAARNCLVGE NHLVKVADFG LSRLMTGDTY TAHAGAKFPI KWTAPESLAY 450
NKFSIKSDVW AFGVLLWEIA TYGMSPYPGI DLSQVYELLE KDYRMERPEG 500
CPEKVYELMR ACWQWNPSDR PSFAEIHQAF ETMFQESSIS DEVEKELGKQ 550
GVRGAVSTLL QAPELPTKTR TSRRAAEHRD TTDVPEMPHS KGQGESDPLD 600
HEPAVSPLLP RKERGPPEGG LNEDERLLPK DKKTNLFSAL IKKKKKTAPT 650
PPKRSSSFRE MDGQPERRGA GEEEGRDISN GALAFTPLDT ADPAKSPKPS 700
NGAGVPNGAL RESGGSGFRS PHLWKKSSTL TSSRLATGEE EGGGSSSKRF 750
LRSCSASCVP HGAKDTEWRS VTLPRDLQST GRQFDSSTFG GHKSEKPALP 800
RKRAGENRSD QVTRGTVTPP PRLVKKNEEA ADEVFKDIME SSPGSSPPNL 850
TPKPLRRQVT VAPASGLPHK EEAGKGSALG TPAAAEPVTP TSKAGSGAPG 900
GTSKGPAEES RVRRHKHSSE SPGRDKGKLS RLKPAPPPPP AASAGKAGGK 950
PSQSPSQEAA GEAVLGAKTK ATSLVDAVNS DAAKPSQPGE GLKKPVLPAT 1000
PKPQSAKPSG TPISPAPVPS TLPSASSALA GDQPSSTAFI PLISTRVSLR 1050
KTRQPPERIA SGAITKGVVL DSTEALCLAI SRNSEQMASH SAVLEAGKNL 1100
YTFCVSYVDS IQQMRNKFAF REAINKLENN LRELQICPAT AGSGPAATQD 1150
FSKLLSSVKE ISDIVQR 1167
Length:1,167
Mass (Da):127,257
Last modified:April 26, 2005 - v1
Checksum:iF05C6B7355BE8945
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209456 mRNA. Translation: BAD92693.1.
RefSeqiNP_005148.2. NM_005157.4.
NP_009297.2. NM_007313.2.
UniGeneiHs.431048.

Genome annotation databases

GeneIDi25.
KEGGihsa:25.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209456 mRNA. Translation: BAD92693.1 .
RefSeqi NP_005148.2. NM_005157.4.
NP_009297.2. NM_007313.2.
UniGenei Hs.431048.

3D structure databases

ProteinModelPortali Q59FK4.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q59FK4.

Proteomic databases

PRIDEi Q59FK4.

Protocols and materials databases

DNASUi 25.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25.
KEGGi hsa:25.

Organism-specific databases

CTDi 25.
H-InvDB HIX0008474.
PharmGKBi PA24413.

Phylogenomic databases

HOVERGENi HBG004162.
KOi K06619.

Enzyme and pathway databases

SignaLinki Q59FK4.

Miscellaneous databases

GenomeRNAii 25.
NextBioi 79.

Gene expression databases

ArrayExpressi Q59FK4.
Bgeei Q59FK4.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR015015. F-actin_binding.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF08919. F_actin_bind. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00808. FABD. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59FK4_HUMAN
AccessioniPrimary (citable) accession number: Q59FK4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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