Protein kinase C, alpha variant - Homo sapiens (Human)

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Unreviewed, UniProtKB/TrEMBL Q59FI5 (Q59FI5_HUMAN)

Last modified January 19, 2010. Version 53. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein names	Submitted name: Protein kinase C, alpha variant EMBL BAD92712.1
Organism	Homo sapiens (Human) EMBL BAD92712.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	461 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. Spearmint SPM002219

Sequence similarities

Belongs to the protein kinase superfamily.

Contains 1 C2 domain.

Contains 1 protein kinase domain.

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Ontologies

Keywords
Domain	Repeat Spearmint SPM002219
Ligand	ATP-binding RuleBase RU000304V2 Spearmint SPM002219 Metal-binding Spearmint SPM002219 Nucleotide-binding Zinc Spearmint SPM002219
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305V3 Spearmint SPM002219 Transferase
Gene Ontology (GO)
Biological process	aging Inferred from electronic annotation. Source: Compara cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara central nervous system neuron axonogenesis Inferred from electronic annotation. Source: Compara chondrocyte differentiation Inferred from electronic annotation. Source: Compara inactivation of MAPK activity Inferred from electronic annotation. Source: Compara induction of apoptosis by intracellular signals Inferred from electronic annotation. Source: Compara induction of positive chemotaxis Inferred from electronic annotation. Source: Compara learning or memory Inferred from electronic annotation. Source: Compara negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of glucose import Inferred from electronic annotation. Source: Compara negative regulation of heart contraction Inferred from electronic annotation. Source: Compara negative regulation of insulin receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of protein amino acid phosphorylation Inferred from electronic annotation. Source: Compara negative regulation of translation Inferred from electronic annotation. Source: Compara neutrophil chemotaxis Inferred from electronic annotation. Source: Compara peptidyl-serine phosphorylation Inferred from electronic annotation. Source: Compara peptidyl-threonine phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of exocytosis Inferred from electronic annotation. Source: Compara positive regulation of inflammatory response Inferred from electronic annotation. Source: Compara positive regulation of protein amino acid phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of smooth muscle cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of synaptogenesis Inferred from electronic annotation. Source: Compara regulation of muscle contraction Inferred from electronic annotation. Source: Compara regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara regulation of receptor-mediated endocytosis Inferred from electronic annotation. Source: Compara regulation of the force of heart contraction Inferred from electronic annotation. Source: Compara response to antibiotic Inferred from electronic annotation. Source: Compara response to corticosterone stimulus Inferred from electronic annotation. Source: Compara response to estradiol stimulus Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to mechanical stimulus Inferred from electronic annotation. Source: Compara response to organic cyclic substance Inferred from electronic annotation. Source: Compara response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara response to reactive oxygen species Inferred from electronic annotation. Source: Compara response to toxin Inferred from electronic annotation. Source: Compara
Cellular component	cytosol Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara protein complex Inferred from electronic annotation. Source: Compara synaptosome Inferred from electronic annotation. Source: Compara
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-dependent protein kinase C activity Inferred from electronic annotation. Source: Compara protein binding Inferred from electronic annotation. Source: Compara zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Experimental info

Non-terminal residue

EMBL BAD92712.1

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Sequences

Sequence

Length

Mass (Da)

Tools

Q59FI5-1 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: EC71B752C041F02D
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FASTA

461

52,976

        10         20         30         40         50         60 
DPTHSPKDPR SKHKFKIHTY GSPTFCDHCG SLLYGLIHQG MKCDTCDMNV HKQCVINVPS 

        70         80         90        100        110        120 
LCGMDHTEKR GRIYLKAEVA DEKLHVTVRD AKNLIPMDPN GLSDPYVKLK LIPDPKNESK 

       130        140        150        160        170        180 
QKTKTIRSTL NPQWNESFTF KLKPSDKDRR LSVEIWDWDR TTRNDFMGSL SFGVSELMKM 

       190        200        210        220        230        240 
PASGWYKLLN QEEGEYYNVP IPEGDEEGNM ELRQKFEKAK LGPAGNKVIS PSEDRKQPSN 

       250        260        270        280        290        300 
NLDRVKLTDF NFLMVLGKGS FGKVMLADRK GTEELYAIKI LKKDVVIQDD DVECTMVEKR 

       310        320        330        340        350        360 
VLALLDKPPF LTQLHSCFQT VDRLYFVMEY VNGGDLMYHI QQVGKFKEPQ AVFYVAEISI 

       370        380        390        400        410        420 
GLFFLHKRGI IYRDLKLDNV MLDSEGHIKI ADFGMCKEHM MDGVTTRTFC GTPDYIAPEI 

       430        440        450        460 
IAYQPYGKSV DWWAYGVLLY EMLAGQVMFC YIFMFVYCCV M

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References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92712.1.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209475 mRNA. Translation: BAD92712.1.
IPI	IPI00385449.
UniGene	Hs.531704 Hs.708867
3D structure databases
SMR	Q59FI5. Positions 8-80, 67-203, 247-449.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59FI5.
Genome annotation databases
Ensembl	ENST00000284384; ENSP00000284384; ENSG00000154229; Homo sapiens. [Genome view]
UCSC	uc002jfo.1. human.
Organism-specific databases
HGNC	HGNC:9393. PRKCA.
Phylogenomic databases
HOVERGEN	Q59FI5.
Gene expression databases
ArrayExpress	Q59FI5.
Bgee	Q59FI5.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR020477. C2_region. IPR020454. DAG/PE_bd. IPR011009. Kinase-like_dom. IPR015745. PKC. IPR002219. Prot_Kinase_C-like_PE/DAG_bd. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. [Graphical view]
PANTHER	PTHR22985:SF86. PKC. 1 hit.
Pfam	PF00130. C1_1. 1 hit. PF00168. C2. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00360. C2DOMAIN. PR00008. DAGPEDOMAIN.
SMART	SM00109. C1. 1 hit. SM00239. C2. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

Q59FI5_HUMAN

Accession

Primary (citable) accession number: Q59FI5

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	January 19, 2010
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information