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Protein
Submitted name:

Myeloid/lymphoid or mixed-lineage leukemia 2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Myeloid/lymphoid or mixed-lineage leukemia 2 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30846.

PTM / Processingi

Proteomic databases

PaxDbiQ59FG6.
PeptideAtlasiQ59FG6.
PRIDEiQ59FG6.

Expressioni

Gene expression databases

BgeeiQ59FG6.
GenevisibleiQ59FG6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000301067.

Structurei

3D structure databases

ProteinModelPortaliQ59FG6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2342 – 240261FYR N-terminalInterPro annotationAdd
BLAST
Domaini2403 – 248886FYR C-terminalInterPro annotationAdd
BLAST
Domaini2564 – 2680117SETInterPro annotationAdd
BLAST
Domaini2688 – 270417Post-SETInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili731 – 77949Sequence analysisAdd
BLAST
Coiled coili883 – 91028Sequence analysisAdd
BLAST
Coiled coili1064 – 113976Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG4443. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000168503.
HOVERGENiHBG006738.
KOiK09187.

Family and domain databases

InterProiIPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR001965. Znf_PHD.
[Graphical view]
PfamiPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59FG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SARFPSTPGP ELGRQALGSP LAGISTRLPG PGEPVPGPAG PAQFIELRHN
60 70 80 90 100
VQKGLGPGGT PFPGQGPPQR PRFYPVSEDP HRLAPEGLRG LAVSGLPPQK
110 120 130 140 150
PSAPPAPELN NSLHPTPHTK GPTLPTGLEL VNRPPSSTEL GRPNPLALEA
160 170 180 190 200
GKLPCEDPEL DDDFDAHKAL EDDEELAHLG LGVDVAKGDD ELGTLENLET
210 220 230 240 250
NDPHLDDLLN GDEFDLLAYT DPELDTGDKK DIFNEHLRLV ESANEKAERE
260 270 280 290 300
ALLRGVEPGP LGPEERPPPA ADASEPRLAS VLPEVKPKVE EGGRHPSPCQ
310 320 330 340 350
FTIATPKVEP APAANSLGLG LKPGQSMMGS RDTRMGTGPF SSSGHTAEKA
360 370 380 390 400
SFGATGGPPA HLLTPSPLSG PGGSSLLEKF ELESGALTLP GGPAASGDEL
410 420 430 440 450
DKMESSLVAS ELPLLIEDLL EHEKKELQKK QQLSAQLQPA QQQQQQQQQH
460 470 480 490 500
SLLSAPGPAQ AMSLPHEGSS PSLAGSQQQL SLGLAGARQP GLPQPLMPTQ
510 520 530 540 550
PPAHALQQRL APSMAMVSNQ GHMLSGQHGG QAGLVPQQSS QPVLSQKPMG
560 570 580 590 600
TMPPSMCMKP QQLAMQQQLA NSFFPDTDLD KFAAEDIIDP IAKAKMVALK
610 620 630 640 650
GIKKVMAQGS IGVAPGMNRQ QVSLLAQRLS GGPSSDLQNH VAAGSGQERS
660 670 680 690 700
AGDPSQPRPN PPTFAQGVIN EADQRQYEEW LFHTQQLLQM QLKVLEEQIG
710 720 730 740 750
VHRKSRKALC AKQRTAKKAG REFPEADAEK LKLVTEQQSK IQKQLDQVRK
760 770 780 790 800
QQKEHTNLMA EYRNKQQQQQ QQQQQQQQQH SAVLALSPSQ SPRLLTKLPG
810 820 830 840 850
QLLPGHGLQP PQGPPGGQAG GLRLTPGGMA LPGQPGGPFL NTALAQQQQQ
860 870 880 890 900
QHSGGAGSLA GPSGGFFPGN LALRSLGPDS RLLQERQLQL QQQRMQLAQK
910 920 930 940 950
LQQQQQQQQQ QQHLLGQVAI QQQQQQGPGV QTNQALGPKP QGLMPPSSHQ
960 970 980 990 1000
GLLVQQLSPQ PPQGPQGMLG PAQVAVLQQQ HPGALGPQGP HRQVLMTQSR
1010 1020 1030 1040 1050
VLSSPQLAQQ GQGLMGHRLV TAQQQQQQQQ HQQQGSMAGL SHLQQSLMSH
1060 1070 1080 1090 1100
SGQPKLSAQP MGSLQQLQQQ QQLQQQQQLQ QQQQQQLQQQ QQLQQQQLQQ
1110 1120 1130 1140 1150
QQQQQQLQQQ QQQQLQQQQQ QLQQQQQQQQ QQFQQQQQQQ QMGLLNQSRT
1160 1170 1180 1190 1200
LLSPQQQQQQ QVALGPGMPA KPLQHFSSPG ALGPTLLLTG KEQNTVDPAV
1210 1220 1230 1240 1250
SSEATEGPST HQGGPLAIGT TPESMATEPG EVKPSLSGDS QLLLVQPQPQ
1260 1270 1280 1290 1300
PQPSSLQLQP PLRLPGQQQQ QVSLLHTAGG GSHGQLGSGS SSEASSVPHL
1310 1320 1330 1340 1350
LAQPSVSLGD QPGSMTQNLL GPQQPMLERP MQNNTGPQPP KPGPVLQSGQ
1360 1370 1380 1390 1400
GLPGVGIMPT VGQLRAQLQG VLAKNPQLRH LSPQQQQQLQ ALLMQRQLQQ
1410 1420 1430 1440 1450
SQAVRQTPPY QEPGTQTSPL QGLLGCQPQL GGFPGPQTGP LQELGAGPRP
1460 1470 1480 1490 1500
QGPPRLPAPP GALSTGPVLG PVHPTPPPSS PQEPKRPSQL PSPSSQLPTE
1510 1520 1530 1540 1550
AQLPPTHPGT PKPQGPTLEP PPGRVSPAAA QLADTLFSKG LGPWDPPDNL
1560 1570 1580 1590 1600
AETQKPEQSS LVPGHLDQVN GQVVPEASQL SIKQEPREEP CALGAQSVKR
1610 1620 1630 1640 1650
EANGEPIGAP GTSNHLLLAG PRSEAGHLLL QKLLRAKNVQ LSTGRGSEGL
1660 1670 1680 1690 1700
RAEINGHIDS KLAGLEQKLQ GTPSNKEDAA ARKPLTPKPK RVQKASDRLV
1710 1720 1730 1740 1750
SSRKKLRKED GVRASEALLK QLKQELSLLP LTEPAITANF SLFAPFGSGC
1760 1770 1780 1790 1800
PVNGQSQLRG AFGSGALPTG PDYYSQLLTK NNLSNPPTPP SSLPPTPPPS
1810 1820 1830 1840 1850
VQQKMVNGVT PSEELGEHPK DAASARDSER ALRDTSEVKS LDLLAALPTP
1860 1870 1880 1890 1900
PHNQTEDVRM ESDEDSDSPD SIVPASSPES ILGEEAPRFP HLGSGRWEQE
1910 1920 1930 1940 1950
DRALSPVIPL IPRASIPVFP DTKPYGALGL EVPGKLPVTT WEKGKGSEVS
1960 1970 1980 1990 2000
VMLTVSAAAA KNLNGVMVAV AELLSMKIPN SYEVLFPESP ARAGTEPKKG
2010 2020 2030 2040 2050
EAEGPGGKEK GLEGKSPDTG PDWLKQFDAV LPGYTLKSQL DILSLLKQES
2060 2070 2080 2090 2100
PAPEPPTQHS YTYNVSNLDV RQLSAPPPEE PSPPPSPLAP SPASPPTEPL
2110 2120 2130 2140 2150
VELPTEPLAE PPVPSPLPLA SSPESARPKP RARPPEEGED SRPPRLKKWK
2160 2170 2180 2190 2200
GVRWKRLRLL LTIQKGSGRQ EDEREVAEFM EQLGTALRPD KVPRDMRRCC
2210 2220 2230 2240 2250
FCHEEGDGAT DGPARLLNLD LDLWVHLNCA LWSTEVYETQ GGALMNVEVA
2260 2270 2280 2290 2300
LHRGLLTKCS LCQRTGATSS CNRMRCPNVY HFACAIRAKC MFFKDKTMLC
2310 2320 2330 2340 2350
PMHKIKGPCE QELSSFAVFR RVYIERDEVK QIASIIQRGE RLHMFRVGGL
2360 2370 2380 2390 2400
VFHAIGQLLP HQMADFHSAT ALYPVGYEAT RIYWSLRTNN RRCCYRCSIG
2410 2420 2430 2440 2450
ENNGRPEFVI KVIEQGLEDL VFTDASPQAV WNRIIEPVAA MRKEADMLRL
2460 2470 2480 2490 2500
FPEYLKGEEL FGLTVHAVLR IAESLPGVES CQNYLFRYGR HPLMELPLMI
2510 2520 2530 2540 2550
NPTGCARSEP KILTHYKRPH TLNSTSMSKA YQSTFTGETN TPYSKQFVHS
2560 2570 2580 2590 2600
KSSQYRRLRT EWKNNVYLAR SRIQGLGLYA AKDLEKHTMV IEYIGTIIRN
2610 2620 2630 2640 2650
EVANRREKIY EEQNRGIYMF RINNEHVIDA TLTGGPARYI NHSCAPNCVA
2660 2670 2680 2690 2700
EVVTFDKEDK IIIISSRRIP KGEELTYDYQ FDFEDDQHKI PCHCGAWNCR

KWMN
Length:2,704
Mass (Da):293,186
Last modified:April 26, 2005 - v1
Checksum:i41D0C6900D23C5ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209494 mRNA. Translation: BAD92731.1.
RefSeqiNP_003473.3. NM_003482.3.
UniGeneiHs.731384.

Genome annotation databases

GeneIDi8085.
KEGGihsa:8085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209494 mRNA. Translation: BAD92731.1.
RefSeqiNP_003473.3. NM_003482.3.
UniGeneiHs.731384.

3D structure databases

ProteinModelPortaliQ59FG6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000301067.

Proteomic databases

PaxDbiQ59FG6.
PeptideAtlasiQ59FG6.
PRIDEiQ59FG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8085.
KEGGihsa:8085.

Organism-specific databases

CTDi8085.
PharmGKBiPA30846.

Phylogenomic databases

eggNOGiKOG4443. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000168503.
HOVERGENiHBG006738.
KOiK09187.

Miscellaneous databases

GenomeRNAii8085.

Gene expression databases

BgeeiQ59FG6.
GenevisibleiQ59FG6. HS.

Family and domain databases

InterProiIPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR001965. Znf_PHD.
[Graphical view]
PfamiPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59FG6_HUMAN
AccessioniPrimary (citable) accession number: Q59FG6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 6, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.