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Protein
Submitted name:

Low density lipoprotein-related protein 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Low density lipoprotein-related protein 1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2239 – 225921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation, LipoproteinImported

Proteomic databases

PaxDbiQ59FG2.
PRIDEiQ59FG2.

Expressioni

Gene expression databases

GenevisibleiQ59FG2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000243077.

Structurei

3D structure databases

ProteinModelPortaliQ59FG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini798 – 83336EGF-likeInterPro annotationAdd
BLAST
Domaini2011 – 204434EGF-likeInterPro annotationAdd
BLAST
Domaini2047 – 208337EGF-likeInterPro annotationAdd
BLAST
Domaini2084 – 211633EGF-likeInterPro annotationAdd
BLAST
Domaini2119 – 215537EGF-likeInterPro annotationAdd
BLAST
Domaini2190 – 222435EGF-likeInterPro annotationAdd
BLAST

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
HOVERGENiHBG097941.
KOiK04550.

Family and domain databases

Gene3Di2.120.10.30. 3 hits.
4.10.400.10. 20 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR032485. DUF5050.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF16472. DUF5050. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 19 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 17 hits.
SM00179. EGF_CA. 5 hits.
SM00192. LDLa. 21 hits.
SM00135. LY. 13 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 20 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 16 hits.
PS50068. LDLRA_2. 21 hits.
PS51120. LDLRB. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59FG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VCFVCLSHLL PPDSVYLLYS ERTILKSIHL SDERNLNAPV QPFEDPEHMK
60 70 80 90 100
NVIALAFDYR AGTSPGTPNR IFFSDIHFGN IQQINDDGSR RITIVENVGS
110 120 130 140 150
VEGLAYHRGW DTLYWTSYTT STITRHTVDQ TRPGAFERET VITMSGDDHP
160 170 180 190 200
RAFVLDECQN LMFWTNWNEQ HPSIMRAALS GANVLTLIEK DIRTPNGLAI
210 220 230 240 250
DHRAEKLYFS DATLDKIERC EYDGSHRYVI LKSEPVHPFG LAVYGEHIFW
260 270 280 290 300
TDWVRRAVQR ANKHVGSNMK LLRVDIPQQP MGIIAVANDT NSCELSPCRI
310 320 330 340 350
NNGGCQDLCL LTHQGHVNCS CRGGRILQDD LTCRAVNSSC RAQDEFECAN
360 370 380 390 400
GECINFSLTC DGVPHCKDKS DEKPSYCNSR RCKKTFRQCS NGRCVSNMLW
410 420 430 440 450
CNGADDCGDG SDEIPCNKTA CGVGEFRCRD GTCIGNSSRC NQFVDCEDAS
460 470 480 490 500
DEMNCSATDC SSYFRLGVKG VLFQPCERTS LCYAPSWVCD GANDCGDYSD
510 520 530 540 550
ERDCPGVKRP RCPLNYFACP SGRCIPMSWT CDKEDDCEHG EDETHCNKFC
560 570 580 590 600
SEAQFECQNH RCISKQWLCD GSDDCGDGSD EAAHCEGKTC GPSSFSCPGT
610 620 630 640 650
HVCVPERWLC DGDKDCADGA DESIAAGCLY NSTCDDREFM CQNRQCIPKH
660 670 680 690 700
FVCDHDRDCA DGSDESPECE YPTCGPSEFR CANGRCLSSR QWECDGENDC
710 720 730 740 750
HDQSDEAPKN PHCTSPEHKC NASSQFLCSS GRCVAEALLC NGQDDCGDSS
760 770 780 790 800
DERGCHINEC LSRKLSGCSQ DCEDLKIGFK CRCRPGFRLK DDGRTCADVD
810 820 830 840 850
ECSTTFPCSQ RCINTHGSYK CLCVEGYAPR GGDPHSCKAV TDEEPFLIFA
860 870 880 890 900
NRYYLRKLNL DGSNYTLLKQ GLNNAVALDF DYREQMIYWT DVTTQGSMIR
910 920 930 940 950
RMHLNGSNVQ VLHRTGLSNP DGLAVDWVGG NLYWCDKGRD TIEVSKLNGA
960 970 980 990 1000
YRTVLVSSGL REPRALVVDV QNGYLYWTDW GDHSLIGRIG MDGSSRSVIV
1010 1020 1030 1040 1050
DTKITWPNGL TLDYVTERIY WADAREDYIE FASLDGSNRH VVLSQDIPHI
1060 1070 1080 1090 1100
FALTLFEDYV YWTDWETKSI NRAHKTTGTN KTLLISTLHR PMDLHVFHAL
1110 1120 1130 1140 1150
RQPDVPNHPC KVNNGGCSNL CLLSPGGGHK CACPTNFYLG SDGRTCVSNC
1160 1170 1180 1190 1200
TASQFVCKND KCIPFWWKCD TEDDCGDHSD EPPDCPEFKC RPGQFQCSTG
1210 1220 1230 1240 1250
ICTNPAFICD GDNDCQDNSD EANCDIHVCL PSQFKCTNTN RCIPGIFRCN
1260 1270 1280 1290 1300
GQDNCGDGED ERDCPEVTCA PNQFQCSITK RCIPRVWVCD RDNDCVDGSD
1310 1320 1330 1340 1350
EPANCTQMTC GVDEFRCKDS GRCIPARWKC DGEDDCGDGS DEPKEECDER
1360 1370 1380 1390 1400
TCEPYQFRCK NNRCVPGRWQ CDYDNDCGDN SDEESCTPRP CSESEFSCAN
1410 1420 1430 1440 1450
GRCIAGRWKC DGDHDCADGS DEKDCTPRCD MDQFQCKSGH CIPLRWRCDA
1460 1470 1480 1490 1500
DADCMDGSDE EACGTGVRTC PLDEFQCNNT LCKPLAWKCD GEDDCGDNSD
1510 1520 1530 1540 1550
ENPEECARFV CPPNRPFRCK NDRVCLWIGR QCDGTDNCGD GTDEEDCEPP
1560 1570 1580 1590 1600
TAHTTHCKDK KEFLCRNQRC LSSLRCNMFD DCGDGSDEED CSIDPKLTSC
1610 1620 1630 1640 1650
ATNASICGDE ARCVRTEKAA YCACRSGFHT VPGQPGCQDI NECLRFGTCS
1660 1670 1680 1690 1700
QLCNNTKGGH LCSCARNFMK THNTCKAEGS EYQVLYIADD NEIRSLFPGH
1710 1720 1730 1740 1750
PHSAYEQAFQ GDESVRIDAM DVHVKAGRVY WTNWHTGTIS YRSLPPAAPP
1760 1770 1780 1790 1800
TTSNRHRRQI DRGVTHLNIS GLKMPRGIAI DWVAGNVYWT DSGRDVIEVA
1810 1820 1830 1840 1850
QMKGENRKTL ISGMIDEPHA IVVDPLRGTM YWSDWGNHPK IETAAMDGTL
1860 1870 1880 1890 1900
RETLVQDNIQ WPTGLAVDYH NERLYWADAK LSVIGSIRLN GTDPIVAADS
1910 1920 1930 1940 1950
KRGLSHPFSI DVFEDYIYGV TYINNRVFKI HKFGHSPLVN LTGGLSHASD
1960 1970 1980 1990 2000
VVLYHQHKQP EVTNPCDRKK CEWLCLLSPS GPVCTCPNGK RLDNGTCVPV
2010 2020 2030 2040 2050
PSPTPPPDAP RPGTCNLQCF NGGSCFLNAR RQPKCRCQPR YTGDKCELDQ
2060 2070 2080 2090 2100
CWEHCRNGGT CAASPSGMPT CRCPTGFTGP KCTQQVCAGY CANNSTCTVN
2110 2120 2130 2140 2150
QGNQPQCRCL PGFLGDRCQY RQCSGYCENF GTCQMAADGS RQCRCTAYFE
2160 2170 2180 2190 2200
GSRCEVNKCS RCLEGACVVN KQSGDVTCNC TDGRVAPSCL TCVGHCSNGG
2210 2220 2230 2240 2250
SCTMNSKMMP ECQCPPHMTG PRCEEHVFSQ QQPGHIASIL IPLLLLLLLV
2260 2270 2280 2290 2300
LVAGVVFWYK RRVQGAKGFQ HQRMTNGAMN VEIGNPTYKM YEGGEPDDVG
2310 2320 2330 2340 2350
GLLDADFALD PDKPTNFTNP VYATLYMGGH GSRHSLASTD EKRELLGRGP

EDEIGDPLA
Length:2,359
Mass (Da):262,019
Last modified:April 26, 2005 - v1
Checksum:i2588B2908EA320B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209498 mRNA. Translation: BAD92735.1.
RefSeqiNP_002323.2. NM_002332.2.
UniGeneiHs.162757.

Genome annotation databases

GeneIDi4035.
KEGGihsa:4035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209498 mRNA. Translation: BAD92735.1.
RefSeqiNP_002323.2. NM_002332.2.
UniGeneiHs.162757.

3D structure databases

ProteinModelPortaliQ59FG2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000243077.

Proteomic databases

PaxDbiQ59FG2.
PRIDEiQ59FG2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4035.
KEGGihsa:4035.

Organism-specific databases

CTDi4035.

Phylogenomic databases

eggNOGiKOG1215. Eukaryota.
ENOG410XP34. LUCA.
HOVERGENiHBG097941.
KOiK04550.

Miscellaneous databases

GenomeRNAii4035.

Gene expression databases

GenevisibleiQ59FG2. HS.

Family and domain databases

Gene3Di2.120.10.30. 3 hits.
4.10.400.10. 20 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR032485. DUF5050.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF16472. DUF5050. 1 hit.
PF07645. EGF_CA. 1 hit.
PF00057. Ldl_recept_a. 19 hits.
PF00058. Ldl_recept_b. 5 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 17 hits.
SM00179. EGF_CA. 5 hits.
SM00192. LDLa. 21 hits.
SM00135. LY. 13 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 2 hits.
SSF57424. SSF57424. 20 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 6 hits.
PS01187. EGF_CA. 1 hit.
PS01209. LDLRA_1. 16 hits.
PS50068. LDLRA_2. 21 hits.
PS51120. LDLRB. 14 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59FG2_HUMAN
AccessioniPrimary (citable) accession number: Q59FG2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 8, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.