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Q59FE5

- Q59FE5_HUMAN

UniProt

Q59FE5 - Q59FE5_HUMAN

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Protein
Submitted name:

A disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif, 10 preproprotein variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, IntegrinImported, MetalloproteaseImported, Protease

Protein family/group databases

MEROPSiM12.235.

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif, 10 preproprotein variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ59FE5.

Structurei

3D structure databases

ProteinModelPortaliQ59FE5.
SMRiQ59FE5. Positions 24-293, 297-356, 579-701, 746-845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains peptidase M12B domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000004800.
HOVERGENiHBG050620.
KOiK08625.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 5 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 5 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59FE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
QDDGGLSRAP GCGAVCPGHH EHCQVAKLFQ DSSLGSTVNI LVTRLILLTE
60 70 80 90 100
DQPTLEITHH AGKSLDSFCK WQKSIVNHSG HGNAIPENGV ANHDTAVLIT
110 120 130 140 150
RYDICIYKNK PCGTLGLAPV GGMCERERSC SVNEDIGLAT AFTIAHEIGH
160 170 180 190 200
TFGMNHDGVG NSCGARGQDP AKLMAAHITM KTNPFVWSSC SRDYITSFLD
210 220 230 240 250
SGLGLCLNNR PPRQDFVYPT VAPGQAYDAD EQCRFQHGVK SRQCKYGEVC
260 270 280 290 300
SELWCLSKSN RCITNSIPAA EGTLCQTHTI DKGWCYKRVC VPFGSRPEGV
310 320 330 340 350
DGAWGPWTPW GDCSRTCGGG VSSSSRHCDS PRPTIGGKYC LGERRRHRSC
360 370 380 390 400
NTDDCPPGSQ DFREVQCSEF DSIPFRGKFY KWKTYRGGGV KACSLTCLAE
410 420 430 440 450
GFNFYTERAA AVVDGTPCRP DTVDICVSGE CKHVGCDRVL GSDLREDKCR
460 470 480 490 500
VCGGDGSACE TIEGVFSPAS PGAGYEDVVW IPKGSVHIFI QDLNLSLSHL
510 520 530 540 550
ALKGDQESLL LEGLPGTPQP HRLPLAGTTF QLRQGPDQVQ SLEALGPINA
560 570 580 590 600
SLIVMVLART ELPALRYRFN APIARDSLPP YSWHYAPWTK CSAQCAGGSQ
610 620 630 640 650
VQAVECRNQL DSSAVAPHYC SAHSKLPKRQ RACNTEPCPP DWVVGNWSLC
660 670 680 690 700
SRSCDAGVRS RSVVCQRRVS AAEEKALDDS ACPQPRPPVL EACHGPTCPP
710 720 730 740 750
EWAALDWSEV SRPLPSRPLG CPGGVSTETP LRGLQVSCPL LTSHWGSTLS
760 770 780 790 800
TKRPFQLQCT PSCGPGLRHR VVLCKSADHR ATLPPAHCSP AAKPPATMRC
810 820 830 840
NLRRCPPARW VAGEWGECSA QCGVGQRQRS VRCTSHTGQA SHECTEA
Length:847
Mass (Da):91,652
Last modified:April 26, 2005 - v1
Checksum:i5E64B143620CE84F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei847 – 8471Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209515 mRNA. Translation: BAD92752.1.
RefSeqiNP_112219.3. NM_030957.3.
UniGeneiHs.657508.

Genome annotation databases

GeneIDi81794.
KEGGihsa:81794.
UCSCiuc002mkk.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209515 mRNA. Translation: BAD92752.1 .
RefSeqi NP_112219.3. NM_030957.3.
UniGenei Hs.657508.

3D structure databases

ProteinModelPortali Q59FE5.
SMRi Q59FE5. Positions 24-293, 297-356, 579-701, 746-845.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M12.235.

Proteomic databases

PRIDEi Q59FE5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81794.
KEGGi hsa:81794.
UCSCi uc002mkk.1. human.

Organism-specific databases

CTDi 81794.

Phylogenomic databases

HOGENOMi HOG000004800.
HOVERGENi HBG050620.
KOi K08625.

Miscellaneous databases

GenomeRNAii 81794.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00209. TSP1. 5 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 5 hits.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59FE5_HUMAN
AccessioniPrimary (citable) accession number: Q59FE5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.