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Q59FE5

- Q59FE5_HUMAN

UniProt

Q59FE5 - Q59FE5_HUMAN

Protein
Submitted name:

A disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif, 10 preproprotein variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. metalloendopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. integrin-mediated signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, IntegrinImported, MetalloproteaseImported, Protease

    Protein family/group databases

    MEROPSiM12.235.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    A disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif, 10 preproprotein variantImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: InterPro

    PTM / Processingi

    Proteomic databases

    PRIDEiQ59FE5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59FE5.
    SMRiQ59FE5. Positions 24-293, 297-356, 579-701, 746-845.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains peptidase M12B domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000004800.
    HOVERGENiHBG050620.
    KOiK08625.

    Family and domain databases

    Gene3Di3.40.390.10. 1 hit.
    InterProiIPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view]
    PfamiPF05986. ADAM_spacer1. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 3 hits.
    [Graphical view]
    PRINTSiPR01857. ADAMTSFAMILY.
    SMARTiSM00209. TSP1. 5 hits.
    [Graphical view]
    SUPFAMiSSF82895. SSF82895. 5 hits.
    PROSITEiPS50215. ADAM_MEPRO. 1 hit.
    PS50092. TSP1. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q59FE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    QDDGGLSRAP GCGAVCPGHH EHCQVAKLFQ DSSLGSTVNI LVTRLILLTE    50
    DQPTLEITHH AGKSLDSFCK WQKSIVNHSG HGNAIPENGV ANHDTAVLIT 100
    RYDICIYKNK PCGTLGLAPV GGMCERERSC SVNEDIGLAT AFTIAHEIGH 150
    TFGMNHDGVG NSCGARGQDP AKLMAAHITM KTNPFVWSSC SRDYITSFLD 200
    SGLGLCLNNR PPRQDFVYPT VAPGQAYDAD EQCRFQHGVK SRQCKYGEVC 250
    SELWCLSKSN RCITNSIPAA EGTLCQTHTI DKGWCYKRVC VPFGSRPEGV 300
    DGAWGPWTPW GDCSRTCGGG VSSSSRHCDS PRPTIGGKYC LGERRRHRSC 350
    NTDDCPPGSQ DFREVQCSEF DSIPFRGKFY KWKTYRGGGV KACSLTCLAE 400
    GFNFYTERAA AVVDGTPCRP DTVDICVSGE CKHVGCDRVL GSDLREDKCR 450
    VCGGDGSACE TIEGVFSPAS PGAGYEDVVW IPKGSVHIFI QDLNLSLSHL 500
    ALKGDQESLL LEGLPGTPQP HRLPLAGTTF QLRQGPDQVQ SLEALGPINA 550
    SLIVMVLART ELPALRYRFN APIARDSLPP YSWHYAPWTK CSAQCAGGSQ 600
    VQAVECRNQL DSSAVAPHYC SAHSKLPKRQ RACNTEPCPP DWVVGNWSLC 650
    SRSCDAGVRS RSVVCQRRVS AAEEKALDDS ACPQPRPPVL EACHGPTCPP 700
    EWAALDWSEV SRPLPSRPLG CPGGVSTETP LRGLQVSCPL LTSHWGSTLS 750
    TKRPFQLQCT PSCGPGLRHR VVLCKSADHR ATLPPAHCSP AAKPPATMRC 800
    NLRRCPPARW VAGEWGECSA QCGVGQRQRS VRCTSHTGQA SHECTEA 847
    Length:847
    Mass (Da):91,652
    Last modified:April 26, 2005 - v1
    Checksum:i5E64B143620CE84F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei847 – 8471Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209515 mRNA. Translation: BAD92752.1.
    RefSeqiNP_112219.3. NM_030957.3.
    UniGeneiHs.657508.

    Genome annotation databases

    GeneIDi81794.
    KEGGihsa:81794.
    UCSCiuc002mkk.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209515 mRNA. Translation: BAD92752.1 .
    RefSeqi NP_112219.3. NM_030957.3.
    UniGenei Hs.657508.

    3D structure databases

    ProteinModelPortali Q59FE5.
    SMRi Q59FE5. Positions 24-293, 297-356, 579-701, 746-845.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi M12.235.

    Proteomic databases

    PRIDEi Q59FE5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 81794.
    KEGGi hsa:81794.
    UCSCi uc002mkk.1. human.

    Organism-specific databases

    CTDi 81794.

    Phylogenomic databases

    HOGENOMi HOG000004800.
    HOVERGENi HBG050620.
    KOi K08625.

    Miscellaneous databases

    GenomeRNAii 81794.

    Family and domain databases

    Gene3Di 3.40.390.10. 1 hit.
    InterProi IPR010294. ADAM_spacer1.
    IPR024079. MetalloPept_cat_dom.
    IPR001590. Peptidase_M12B.
    IPR013273. Peptidase_M12B_ADAM-TS.
    IPR000884. Thrombospondin_1_rpt.
    [Graphical view ]
    Pfami PF05986. ADAM_spacer1. 1 hit.
    PF01421. Reprolysin. 1 hit.
    PF00090. TSP_1. 3 hits.
    [Graphical view ]
    PRINTSi PR01857. ADAMTSFAMILY.
    SMARTi SM00209. TSP1. 5 hits.
    [Graphical view ]
    SUPFAMi SSF82895. SSF82895. 5 hits.
    PROSITEi PS50215. ADAM_MEPRO. 1 hit.
    PS50092. TSP1. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiQ59FE5_HUMAN
    AccessioniPrimary (citable) accession number: Q59FE5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.