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Q59FE5

- Q59FE5_HUMAN

UniProt

Q59FE5 - Q59FE5_HUMAN

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Protein
Submitted name: A disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif, 10 preproprotein variant
Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. metalloendopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. integrin-mediated signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, IntegrinImported, MetalloproteaseSAAS annotationsImported, Protease

Protein family/group databases

MEROPSiM12.235.

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif, 10 preproprotein variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ59FE5.

Structurei

3D structure databases

ProteinModelPortaliQ59FE5.
SMRiQ59FE5. Positions 24-293, 297-356, 579-701, 746-845.

Family & Domainsi

Sequence similaritiesi

Contains peptidase M12B domain.SAAS annotations

Phylogenomic databases

HOGENOMiHOG000004800.
HOVERGENiHBG050620.
KOiK08625.

Family and domain databases

Gene3Di3.40.390.10. 1 hit.
InterProiIPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 5 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 5 hits.
PROSITEiPS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59FE5-1 [UniParc]FASTAAdd to Basket

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QDDGGLSRAP GCGAVCPGHH EHCQVAKLFQ DSSLGSTVNI LVTRLILLTE    50
DQPTLEITHH AGKSLDSFCK WQKSIVNHSG HGNAIPENGV ANHDTAVLIT 100
RYDICIYKNK PCGTLGLAPV GGMCERERSC SVNEDIGLAT AFTIAHEIGH 150
TFGMNHDGVG NSCGARGQDP AKLMAAHITM KTNPFVWSSC SRDYITSFLD 200
SGLGLCLNNR PPRQDFVYPT VAPGQAYDAD EQCRFQHGVK SRQCKYGEVC 250
SELWCLSKSN RCITNSIPAA EGTLCQTHTI DKGWCYKRVC VPFGSRPEGV 300
DGAWGPWTPW GDCSRTCGGG VSSSSRHCDS PRPTIGGKYC LGERRRHRSC 350
NTDDCPPGSQ DFREVQCSEF DSIPFRGKFY KWKTYRGGGV KACSLTCLAE 400
GFNFYTERAA AVVDGTPCRP DTVDICVSGE CKHVGCDRVL GSDLREDKCR 450
VCGGDGSACE TIEGVFSPAS PGAGYEDVVW IPKGSVHIFI QDLNLSLSHL 500
ALKGDQESLL LEGLPGTPQP HRLPLAGTTF QLRQGPDQVQ SLEALGPINA 550
SLIVMVLART ELPALRYRFN APIARDSLPP YSWHYAPWTK CSAQCAGGSQ 600
VQAVECRNQL DSSAVAPHYC SAHSKLPKRQ RACNTEPCPP DWVVGNWSLC 650
SRSCDAGVRS RSVVCQRRVS AAEEKALDDS ACPQPRPPVL EACHGPTCPP 700
EWAALDWSEV SRPLPSRPLG CPGGVSTETP LRGLQVSCPL LTSHWGSTLS 750
TKRPFQLQCT PSCGPGLRHR VVLCKSADHR ATLPPAHCSP AAKPPATMRC 800
NLRRCPPARW VAGEWGECSA QCGVGQRQRS VRCTSHTGQA SHECTEA 847
Length:847
Mass (Da):91,652
Last modified:April 26, 2005 - v1
Checksum:i5E64B143620CE84F
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei847 – 8471Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209515 mRNA. Translation: BAD92752.1.
RefSeqiNP_112219.3. NM_030957.3.
UniGeneiHs.657508.

Genome annotation databases

GeneIDi81794.
KEGGihsa:81794.
UCSCiuc002mkk.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209515 mRNA. Translation: BAD92752.1 .
RefSeqi NP_112219.3. NM_030957.3.
UniGenei Hs.657508.

3D structure databases

ProteinModelPortali Q59FE5.
SMRi Q59FE5. Positions 24-293, 297-356, 579-701, 746-845.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M12.235.

Proteomic databases

PRIDEi Q59FE5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81794.
KEGGi hsa:81794.
UCSCi uc002mkk.1. human.

Organism-specific databases

CTDi 81794.

Phylogenomic databases

HOGENOMi HOG000004800.
HOVERGENi HBG050620.
KOi K08625.

Miscellaneous databases

GenomeRNAii 81794.

Family and domain databases

Gene3Di 3.40.390.10. 1 hit.
InterProi IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. Thrombospondin_1_rpt.
[Graphical view ]
Pfami PF05986. ADAM_spacer1. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 3 hits.
[Graphical view ]
PRINTSi PR01857. ADAMTSFAMILY.
SMARTi SM00209. TSP1. 5 hits.
[Graphical view ]
SUPFAMi SSF82895. SSF82895. 5 hits.
PROSITEi PS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59FE5_HUMAN
AccessioniPrimary (citable) accession number: Q59FE5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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