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Protein
Submitted name:

A disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif, 10 preproprotein variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi146Zinc; catalyticPROSITE-ProRule annotation1
Active sitei147PROSITE-ProRule annotation1
Metal bindingi150Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi156Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, IntegrinImported, MetalloproteaseImported, Protease
LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
A disintegrin-like and metalloprotease (Reprolysin type) with thrombospondin type 1 motif, 10 preproprotein variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PRIDEiQ59FE5.

Structurei

3D structure databases

ProteinModelPortaliQ59FE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 211Peptidase M12BInterPro annotationAdd BLAST187

Phylogenomic databases

HOGENOMiHOG000004800.
HOVERGENiHBG050620.
KOiK08625.

Family and domain databases

Gene3Di2.20.100.10. 5 hits.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. TSP1_rpt.
PfamiView protein in Pfam
PF05986. ADAM_spacer1. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiView protein in SMART
SM00209. TSP1. 5 hits.
SUPFAMiSSF82895. SSF82895. 5 hits.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 4 hits.

Sequencei

Sequence statusi: Fragment.

Q59FE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QDDGGLSRAP GCGAVCPGHH EHCQVAKLFQ DSSLGSTVNI LVTRLILLTE
60 70 80 90 100
DQPTLEITHH AGKSLDSFCK WQKSIVNHSG HGNAIPENGV ANHDTAVLIT
110 120 130 140 150
RYDICIYKNK PCGTLGLAPV GGMCERERSC SVNEDIGLAT AFTIAHEIGH
160 170 180 190 200
TFGMNHDGVG NSCGARGQDP AKLMAAHITM KTNPFVWSSC SRDYITSFLD
210 220 230 240 250
SGLGLCLNNR PPRQDFVYPT VAPGQAYDAD EQCRFQHGVK SRQCKYGEVC
260 270 280 290 300
SELWCLSKSN RCITNSIPAA EGTLCQTHTI DKGWCYKRVC VPFGSRPEGV
310 320 330 340 350
DGAWGPWTPW GDCSRTCGGG VSSSSRHCDS PRPTIGGKYC LGERRRHRSC
360 370 380 390 400
NTDDCPPGSQ DFREVQCSEF DSIPFRGKFY KWKTYRGGGV KACSLTCLAE
410 420 430 440 450
GFNFYTERAA AVVDGTPCRP DTVDICVSGE CKHVGCDRVL GSDLREDKCR
460 470 480 490 500
VCGGDGSACE TIEGVFSPAS PGAGYEDVVW IPKGSVHIFI QDLNLSLSHL
510 520 530 540 550
ALKGDQESLL LEGLPGTPQP HRLPLAGTTF QLRQGPDQVQ SLEALGPINA
560 570 580 590 600
SLIVMVLART ELPALRYRFN APIARDSLPP YSWHYAPWTK CSAQCAGGSQ
610 620 630 640 650
VQAVECRNQL DSSAVAPHYC SAHSKLPKRQ RACNTEPCPP DWVVGNWSLC
660 670 680 690 700
SRSCDAGVRS RSVVCQRRVS AAEEKALDDS ACPQPRPPVL EACHGPTCPP
710 720 730 740 750
EWAALDWSEV SRPLPSRPLG CPGGVSTETP LRGLQVSCPL LTSHWGSTLS
760 770 780 790 800
TKRPFQLQCT PSCGPGLRHR VVLCKSADHR ATLPPAHCSP AAKPPATMRC
810 820 830 840
NLRRCPPARW VAGEWGECSA QCGVGQRQRS VRCTSHTGQA SHECTEA
Length:847
Mass (Da):91,652
Last modified:April 26, 2005 - v1
Checksum:i5E64B143620CE84F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei847Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209515 mRNA. Translation: BAD92752.1.
RefSeqiNP_112219.3. NM_030957.3.
UniGeneiHs.657508.

Genome annotation databases

GeneIDi81794.
KEGGihsa:81794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209515 mRNA. Translation: BAD92752.1.
RefSeqiNP_112219.3. NM_030957.3.
UniGeneiHs.657508.

3D structure databases

ProteinModelPortaliQ59FE5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ59FE5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81794.
KEGGihsa:81794.

Organism-specific databases

CTDi81794.

Phylogenomic databases

HOGENOMiHOG000004800.
HOVERGENiHBG050620.
KOiK08625.

Miscellaneous databases

GenomeRNAii81794.

Family and domain databases

Gene3Di2.20.100.10. 5 hits.
3.40.390.10. 1 hit.
InterProiView protein in InterPro
IPR010294. ADAM_spacer1.
IPR024079. MetalloPept_cat_dom.
IPR001590. Peptidase_M12B.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR000884. TSP1_rpt.
PfamiView protein in Pfam
PF05986. ADAM_spacer1. 1 hit.
PF01421. Reprolysin. 1 hit.
PF00090. TSP_1. 4 hits.
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiView protein in SMART
SM00209. TSP1. 5 hits.
SUPFAMiSSF82895. SSF82895. 5 hits.
PROSITEiView protein in PROSITE
PS50215. ADAM_MEPRO. 1 hit.
PS50092. TSP1. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59FE5_HUMAN
AccessioniPrimary (citable) accession number: Q59FE5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 12, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.