Q59FD4 (Q59FD4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Hexokinase 1 isoform HKI variant EMBL BAD92763.1
Organism	Homo sapiens (Human) EMBL BAD92763.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	949 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the hexokinase family. RuleBase RU004510

Ontologies

Keywords
Biological process	Glycolysis SAAS SAAS022672 RuleBase RU004049
Ligand	ATP-binding SAAS SAAS022672 RuleBase RU004049 Nucleotide-binding
Molecular function	Kinase SAAS SAAS022672 RuleBase RU004049 EMBL BAD92763.1 Transferase
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92763.1

Sequences

	Sequence		Length	Mass (Da)
	Q59FD4 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 54972BD394467EA3	FASTA	949	105,804
	10 20 30 40 50 60 GAAEQPPEDH GSPGLRRTDR PHACRPATPT ASMIAAQLLA YYFTELKDDQ VKKIDKYLYA 70 80 90 100 110 120 MRLSDETLID IMTRFRKEMK NGLSRDFNPT ATVKMLPTFV RSIPDGSEKG DFIALDLGGS 130 140 150 160 170 180 SFRILRVQVN HEKNQNVHME SEVYDTPENI VHGSGSQLFD HVAECLGDFM EKRKIKDKKL 190 200 210 220 230 240 PVGFTFSFPC QQSKIDEAIL ITWTKRFKAS GVEGADVVKL LNKAIKKRGD YDANIVAVVN 250 260 270 280 290 300 DTVGTMMTCG YDDQHCEVGL IIGTGTNACY MEELRHIDLV EGDEGRMCIN TEWGAFGDDG 310 320 330 340 350 360 SLEDIRTEFD REIDRGSLNP GKQLFEKMVS GMYLGELVRL ILVKMAKEGL LFEGRITPEL 370 380 390 400 410 420 LTRGKFNTSD VSAIEKNKEG LHNAKEILTR LGVEPSDDDC VSVQHVCTIV SFRSANLVAA 430 440 450 460 470 480 TLGAILNRLR DNKGTPRLRT TVGVDGSLYK THPQYSRRFH KTLRRLVPDS DVRFLLSESG 490 500 510 520 530 540 SGKGAAMVTA VAYRLAEQHR QIEETLAHFH LTKDMLLEVK KRMRAEMELG LRKQTHNNAV 550 560 570 580 590 600 VKMLPSFVRR TPDGTENGDF LALDLGGTNF RVLLVKIRSG KKRTVEMHNK IYAIPIEIMQ 610 620 630 640 650 660 GTGEELFDHI VSCISDFLDY MGIKGPRMPL GFTFSFPCQQ TSLDAGILIT WTKGFKATDC 670 680 690 700 710 720 VGHDVVTLLR DAIKRREEFD LDVVAVVNDT VGTMMTCAYE EPTCEVGLIV GTGSNACYME 730 740 750 760 770 780 EMKNVEMVEG DQGQMCINME WGAFGDNGCL DDIRTHYDRL VDEYSLNAGK QRYEKMISGM 790 800 810 820 830 840 YLGEIVRNIL IDFTKKGFLF RGQISETLKT RGIFETKFLS QIESDRLALL QVRAILQQLG 850 860 870 880 890 900 LNSTCDDSIL VKTVCGVVSR RAAQLCGAGM AAVVDKIREN RGLDRLNVTV GVDGTLYKLH 910 920 930 940 PHFSRIMHQT VKELSPKCNV SFLLSEDGSG KGAALITAVG VRLRTEASS

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92763.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209526 mRNA. Translation: BAD92763.1.
IPI	IPI00220665.
RefSeq	NP_000179.2. NM_000188.2.
UniGene	Hs.370365.
3D structure databases
ProteinModelPortal	Q59FD4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59FD4.
Proteomic databases
PRIDE	Q59FD4.
Protocols and materials databases
DNASU	3098.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3098.
KEGG	hsa:3098.
Organism-specific databases
CTD	3098.
PharmGKB	PA29300.
Phylogenomic databases
HOGENOM	HOG000162671.
HOVERGEN	HBG005020.
KO	K00844.
Gene expression databases
ArrayExpress	Q59FD4.
Bgee	Q59FD4.
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. PTHR19443. 1 hit.
Pfam	PF00349. Hexokinase_1. 2 hits. PF03727. Hexokinase_2. 2 hits. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3098.
NextBio	12293.

Entry information

Entry name

Q59FD4_HUMAN

Accession

Primary (citable) accession number: Q59FD4

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	October 3, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.