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Protein
Submitted name:

Hexokinase 1 isoform HKI variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseSAAS annotationImported, Transferase

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Hexokinase 1 isoform HKI variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29300.

PTM / Processingi

Proteomic databases

PaxDbiQ59FD4.
PeptideAtlasiQ59FD4.
PRIDEiQ59FD4.

Expressioni

Gene expression databases

BgeeiENSG00000156515.
GenevisibleiQ59FD4. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384774.

Structurei

3D structure databases

ProteinModelPortaliQ59FD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 251198Hexokinase_1InterPro annotationAdd
BLAST
Domaini257 – 491235Hexokinase_2InterPro annotationAdd
BLAST
Domaini502 – 699198Hexokinase_1InterPro annotationAdd
BLAST
Domaini705 – 939235Hexokinase_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
KOiK00844.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59FD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GAAEQPPEDH GSPGLRRTDR PHACRPATPT ASMIAAQLLA YYFTELKDDQ
60 70 80 90 100
VKKIDKYLYA MRLSDETLID IMTRFRKEMK NGLSRDFNPT ATVKMLPTFV
110 120 130 140 150
RSIPDGSEKG DFIALDLGGS SFRILRVQVN HEKNQNVHME SEVYDTPENI
160 170 180 190 200
VHGSGSQLFD HVAECLGDFM EKRKIKDKKL PVGFTFSFPC QQSKIDEAIL
210 220 230 240 250
ITWTKRFKAS GVEGADVVKL LNKAIKKRGD YDANIVAVVN DTVGTMMTCG
260 270 280 290 300
YDDQHCEVGL IIGTGTNACY MEELRHIDLV EGDEGRMCIN TEWGAFGDDG
310 320 330 340 350
SLEDIRTEFD REIDRGSLNP GKQLFEKMVS GMYLGELVRL ILVKMAKEGL
360 370 380 390 400
LFEGRITPEL LTRGKFNTSD VSAIEKNKEG LHNAKEILTR LGVEPSDDDC
410 420 430 440 450
VSVQHVCTIV SFRSANLVAA TLGAILNRLR DNKGTPRLRT TVGVDGSLYK
460 470 480 490 500
THPQYSRRFH KTLRRLVPDS DVRFLLSESG SGKGAAMVTA VAYRLAEQHR
510 520 530 540 550
QIEETLAHFH LTKDMLLEVK KRMRAEMELG LRKQTHNNAV VKMLPSFVRR
560 570 580 590 600
TPDGTENGDF LALDLGGTNF RVLLVKIRSG KKRTVEMHNK IYAIPIEIMQ
610 620 630 640 650
GTGEELFDHI VSCISDFLDY MGIKGPRMPL GFTFSFPCQQ TSLDAGILIT
660 670 680 690 700
WTKGFKATDC VGHDVVTLLR DAIKRREEFD LDVVAVVNDT VGTMMTCAYE
710 720 730 740 750
EPTCEVGLIV GTGSNACYME EMKNVEMVEG DQGQMCINME WGAFGDNGCL
760 770 780 790 800
DDIRTHYDRL VDEYSLNAGK QRYEKMISGM YLGEIVRNIL IDFTKKGFLF
810 820 830 840 850
RGQISETLKT RGIFETKFLS QIESDRLALL QVRAILQQLG LNSTCDDSIL
860 870 880 890 900
VKTVCGVVSR RAAQLCGAGM AAVVDKIREN RGLDRLNVTV GVDGTLYKLH
910 920 930 940
PHFSRIMHQT VKELSPKCNV SFLLSEDGSG KGAALITAVG VRLRTEASS
Length:949
Mass (Da):105,804
Last modified:April 26, 2005 - v1
Checksum:i54972BD394467EA3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209526 mRNA. Translation: BAD92763.1.
RefSeqiNP_000179.2. NM_000188.2.
UniGeneiHs.370365.

Genome annotation databases

GeneIDi3098.
KEGGihsa:3098.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209526 mRNA. Translation: BAD92763.1.
RefSeqiNP_000179.2. NM_000188.2.
UniGeneiHs.370365.

3D structure databases

ProteinModelPortaliQ59FD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384774.

Proteomic databases

PaxDbiQ59FD4.
PeptideAtlasiQ59FD4.
PRIDEiQ59FD4.

Protocols and materials databases

DNASUi3098.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3098.
KEGGihsa:3098.

Organism-specific databases

CTDi3098.
PharmGKBiPA29300.

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162671.
HOVERGENiHBG005020.
KOiK00844.

Miscellaneous databases

GenomeRNAii3098.

Gene expression databases

BgeeiENSG00000156515.
GenevisibleiQ59FD4. HS.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 2 hits.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ59FD4_HUMAN
AccessioniPrimary (citable) accession number: Q59FD4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.