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Protein
Submitted name:

Protein tyrosine phosphatase, non-receptor type 2 isoform 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159SubstrateUniRule annotation1
Active sitei193Phosphocysteine intermediateUniRule annotation1
Binding sitei237SubstrateUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolasePROSITE-ProRule annotation, ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase, non-receptor type 2 isoform 1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei365 – 386HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiQ59F91
PeptideAtlasiQ59F91
PRIDEiQ59F91

Expressioni

Gene expression databases

GenevisibleiQ59F91 HS

Structurei

3D structure databases

ProteinModelPortaliQ59F91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 252Tyrosine-protein phosphataseInterPro annotationAdd BLAST221
Domaini167 – 243TYR_PHOSPHATASE_2InterPro annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni193 – 199Substrate bindingUniRule annotation7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili335 – 355Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
HOGENOMiHOG000273908
HOVERGENiHBG008321
KOiK18026

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR012265 Ptpn1/Ptpn2
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PIRSFiPIRSF000926 Tyr-Ptase_nr1, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequencei

Sequence statusi: Fragment.

Q59F91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CQQEFRMYGK DGKGTNWMDQ GDMECRMQEI DDHSRVKLQN AENDYINASL
60 70 80 90 100
VDIEEAQRSY ILTQGPLPNT CCHFWLMVWQ QKTKAVVMLN RIVEKESVKC
110 120 130 140 150
AQYWPTDDQE MLFKETGFSV KLLSEDVKSY YTVHLLQLEN INSGETRTIS
160 170 180 190 200
HFHYTTWPDF GVPESPASFL NFLFKVRESG SLNPDHGPAV IHCSAGIGRS
210 220 230 240 250
GTFSLVDTCL VLMEKGDDIN IKQVLLNMRK YRMGLIQTPD QLRFSYMAII
260 270 280 290 300
EGAKCIKGDS SIQKRWKELS KEDLSPAFDH SPNKIMTEKY NGNRIGLEEE
310 320 330 340 350
KLTGDRCTGL SSKMQDTMEE NSESALRKRI REDRKATTAQ KVQQMKQRLN
360 370 380 390
ENERKRKRWL YWQPILTKMG FMSVILVGAF VGWTLFFQQN AL
Length:392
Mass (Da):45,354
Last modified:April 26, 2005 - v1
Checksum:i64105AA907B72887
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209569 mRNA Translation: BAD92806.1
RefSeqiNP_001295216.1, NM_001308287.1
NP_002819.2, NM_002828.3
UniGeneiHs.654527
Hs.663373

Genome annotation databases

GeneIDi5771
KEGGihsa:5771

Similar proteinsi

Entry informationi

Entry nameiQ59F91_HUMAN
AccessioniPrimary (citable) accession number: Q59F91
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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