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Protein
Submitted name:

Protein tyrosine phosphatase, non-receptor type 2 isoform 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei159 – 1591SubstrateUniRule annotation
Active sitei193 – 1931Phosphocysteine intermediateUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase, non-receptor type 2 isoform 1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei365 – 38622HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ59F91.
PeptideAtlasiQ59F91.
PRIDEiQ59F91.

Expressioni

Gene expression databases

BgeeiENSG00000175354.
GenevisibleiQ59F91. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311857.

Structurei

3D structure databases

ProteinModelPortaliQ59F91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 252221Tyrosine-protein phosphataseInterPro annotationAdd
BLAST
Domaini167 – 24377TYR_PHOSPHATASE_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000273908.
HOVERGENiHBG008321.
KOiK18026.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR012265. Ptpn1/Ptpn2.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59F91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CQQEFRMYGK DGKGTNWMDQ GDMECRMQEI DDHSRVKLQN AENDYINASL
60 70 80 90 100
VDIEEAQRSY ILTQGPLPNT CCHFWLMVWQ QKTKAVVMLN RIVEKESVKC
110 120 130 140 150
AQYWPTDDQE MLFKETGFSV KLLSEDVKSY YTVHLLQLEN INSGETRTIS
160 170 180 190 200
HFHYTTWPDF GVPESPASFL NFLFKVRESG SLNPDHGPAV IHCSAGIGRS
210 220 230 240 250
GTFSLVDTCL VLMEKGDDIN IKQVLLNMRK YRMGLIQTPD QLRFSYMAII
260 270 280 290 300
EGAKCIKGDS SIQKRWKELS KEDLSPAFDH SPNKIMTEKY NGNRIGLEEE
310 320 330 340 350
KLTGDRCTGL SSKMQDTMEE NSESALRKRI REDRKATTAQ KVQQMKQRLN
360 370 380 390
ENERKRKRWL YWQPILTKMG FMSVILVGAF VGWTLFFQQN AL
Length:392
Mass (Da):45,354
Last modified:April 26, 2005 - v1
Checksum:i64105AA907B72887
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209569 mRNA. Translation: BAD92806.1.
RefSeqiNP_001295216.1. NM_001308287.1.
NP_002819.2. NM_002828.3.
UniGeneiHs.654527.
Hs.663373.

Genome annotation databases

GeneIDi5771.
KEGGihsa:5771.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209569 mRNA. Translation: BAD92806.1.
RefSeqiNP_001295216.1. NM_001308287.1.
NP_002819.2. NM_002828.3.
UniGeneiHs.654527.
Hs.663373.

3D structure databases

ProteinModelPortaliQ59F91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311857.

Proteomic databases

PaxDbiQ59F91.
PeptideAtlasiQ59F91.
PRIDEiQ59F91.

Protocols and materials databases

DNASUi5771.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5771.
KEGGihsa:5771.

Organism-specific databases

CTDi5771.

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
HOGENOMiHOG000273908.
HOVERGENiHBG008321.
KOiK18026.

Miscellaneous databases

GenomeRNAii5771.

Gene expression databases

BgeeiENSG00000175354.
GenevisibleiQ59F91. HS.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR012265. Ptpn1/Ptpn2.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF000926. Tyr-Ptase_nr1. 1 hit.
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ59F91_HUMAN
AccessioniPrimary (citable) accession number: Q59F91
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.