Unreviewed, UniProtKB/TrEMBL Q59F77 (Q59F77_HUMAN)

Names and origin

Protein names	Submitted name:     Phospholipase C, beta 2 variant EMBL BAD92820.1
Organism	Homo sapiens (Human) EMBL BAD92820.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	901 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. Contains 1 PI-PLC X-box domain. Contains 1 PI-PLC Y-box domain.

Ontologies

Keywords
Molecular function	Transducer Spearmint SPM001192
Gene Ontology (GO)
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste Inferred from electronic annotation. Source: Compara intracellular signaling cascade Inferred from electronic annotation. Source: Compara lipid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	Golgi apparatus Inferred from electronic annotation. Source: Compara
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphoinositide phospholipase C activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: Compara protein binding Inferred from electronic annotation. Source: Compara signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92820.1

Sequences

	Sequence		Length	Mass (Da)
	Q59F77-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 8BFD658D0FA74529	FASTA	901	101,751
	10 20 30 40 50 60 QRGTLGTMSL LNPVLLPPKV KAYLSQGERF IKWDDETTVA SPVILRVDPK GYYLYWTYQS 70 80 90 100 110 120 KEMEFLDITS IRDTRFGKFA KMPKSQKLRD VFNMDFPDNS FLLKTLTVVS GPDMVDLTFH 130 140 150 160 170 180 NFVSYKENVG KAWAEDVLAL VKHPLTANAS RSTFLDKILV KLKMQLNSEG KIPVKNFFQM 190 200 210 220 230 240 FPADRKRVEA ALSACHLPKG KNDAINPEDF PEPVYKSFLM SLCPRPEIDE IFTSYHAKAK 250 260 270 280 290 300 PYMTKEHLTK FINQKQRDSR LNSLLFPPAR PDQVQGLIDK YEPSGINAQR GQLSPEGMVW 310 320 330 340 350 360 FLCGPENSVL AQDKLLLHHD MTQPLNHYFI NSSHNTYLTA GQFSGLSSAE MYRQVLLSGC 370 380 390 400 410 420 RCVELDCWKG KPPDEEPIIT HGFTMTTDIF FKEAIEAIAE SAFKTSPYPI ILSFENHVDS 430 440 450 460 470 480 PRQQAKMAEY CRTIFGDMLL TEPLEKFPLK PGVPLPSPED LRGKILIKNK KNQFSGPTSS 490 500 510 520 530 540 SKDTGGEAEG SSPPSAPAGE GTVWAGEEGT ELEEEEVEEE EEEESGNLDE EEIKKMQSDE 550 560 570 580 590 600 GTAGLEVTAY EEMSSLVNYI QPTKFVSFEF SAQKNRSYVI SSFTELKAYD LLSKASVQFV 610 620 630 640 650 660 DYNKRQMSRI YPKGTRMDSS NYMPQMFWNA GCQMVALNFQ TMDLPMQQNM AVFEFNGQSG 670 680 690 700 710 720 YLLKHEFMRR PDKQFNPFSV DRIDVVVATT LSITVISGQF LSERSVRTYV EVELFGLPGD 730 740 750 760 770 780 PKRRYRTKLS PSTNSINPVW KEEPFVFEKI LMPELASLRV AVMEEGNKFL GHRIIPINAL 790 800 810 820 830 840 NSGYHHLCLH SESNMPLTMP ALFIFLEMKD YIPGAWADLT VALANPIKFF SAHDTKSVKL 850 860 870 880 890 900 KEAMGGLPEK PFPLASPVAS QVNGALAPTS NGSPGMSFGP HTYWGHLHLC THRHFPLKNF T

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Spleen EMBL BAD92820.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209583 mRNA. Translation: BAD92820.1.
IPI	IPI00784327.
RefSeq	NP_004564.2.
UniGene	Hs.355888
3D structure databases
SMR	Q59F77. Positions 18-810.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59F77.
Genome annotation databases
Ensembl	ENST00000260402; ENSP00000260402; ENSG00000137841; Homo sapiens. [Genome view]
GeneID	5330.
KEGG	hsa:5330.
Organism-specific databases
CTD	5330.
HGNC	HGNC:9055. PLCB2.
Phylogenomic databases
HOVERGEN	Q59F77.
Gene expression databases
ArrayExpress	Q59F77.
Bgee	Q59F77.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-hand-like_dom. IPR015359. Phospholipase_C_EF-hand-like. IPR001192. Phospholipase_C_Pinositol-sp_C. IPR001711. Phospholipase_C_Pinositol-sp_Y. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR000909. PLipase_C_PInositol-sp_X_dom. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit. G3DSA:3.20.20.190. PLC-like_Pdiesterase_TIM-brl. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. [Graphical view]
PRINTS	PR00390. PHPHLIPASEC.
SMART	SM00239. C2. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
PROSITE	PS50004. C2. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	20640.

Entry information

Entry name

Q59F77_HUMAN

Accession

Primary (citable) accession number: Q59F77

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.