Q59F77 (Q59F77_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Phospholipase C, beta 2 variant EMBL BAD92820.1
Organism	Homo sapiens (Human) EMBL BAD92820.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	901 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412 SAAS SAAS001192 Contains 1 PI-PLC X-box domain. SAAS SAAS001192 Contains 1 PI-PLC Y-box domain. SAAS SAAS001192

Ontologies

Keywords
Molecular function	Transducer SAAS SAAS001192
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro lipid metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro phosphatidylinositol phospholipase C activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92820.1

Sequences

	Sequence		Length	Mass (Da)
	Q59F77 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 8BFD658D0FA74529	FASTA	901	101,751
	10 20 30 40 50 60 QRGTLGTMSL LNPVLLPPKV KAYLSQGERF IKWDDETTVA SPVILRVDPK GYYLYWTYQS 70 80 90 100 110 120 KEMEFLDITS IRDTRFGKFA KMPKSQKLRD VFNMDFPDNS FLLKTLTVVS GPDMVDLTFH 130 140 150 160 170 180 NFVSYKENVG KAWAEDVLAL VKHPLTANAS RSTFLDKILV KLKMQLNSEG KIPVKNFFQM 190 200 210 220 230 240 FPADRKRVEA ALSACHLPKG KNDAINPEDF PEPVYKSFLM SLCPRPEIDE IFTSYHAKAK 250 260 270 280 290 300 PYMTKEHLTK FINQKQRDSR LNSLLFPPAR PDQVQGLIDK YEPSGINAQR GQLSPEGMVW 310 320 330 340 350 360 FLCGPENSVL AQDKLLLHHD MTQPLNHYFI NSSHNTYLTA GQFSGLSSAE MYRQVLLSGC 370 380 390 400 410 420 RCVELDCWKG KPPDEEPIIT HGFTMTTDIF FKEAIEAIAE SAFKTSPYPI ILSFENHVDS 430 440 450 460 470 480 PRQQAKMAEY CRTIFGDMLL TEPLEKFPLK PGVPLPSPED LRGKILIKNK KNQFSGPTSS 490 500 510 520 530 540 SKDTGGEAEG SSPPSAPAGE GTVWAGEEGT ELEEEEVEEE EEEESGNLDE EEIKKMQSDE 550 560 570 580 590 600 GTAGLEVTAY EEMSSLVNYI QPTKFVSFEF SAQKNRSYVI SSFTELKAYD LLSKASVQFV 610 620 630 640 650 660 DYNKRQMSRI YPKGTRMDSS NYMPQMFWNA GCQMVALNFQ TMDLPMQQNM AVFEFNGQSG 670 680 690 700 710 720 YLLKHEFMRR PDKQFNPFSV DRIDVVVATT LSITVISGQF LSERSVRTYV EVELFGLPGD 730 740 750 760 770 780 PKRRYRTKLS PSTNSINPVW KEEPFVFEKI LMPELASLRV AVMEEGNKFL GHRIIPINAL 790 800 810 820 830 840 NSGYHHLCLH SESNMPLTMP ALFIFLEMKD YIPGAWADLT VALANPIKFF SAHDTKSVKL 850 860 870 880 890 900 KEAMGGLPEK PFPLASPVAS QVNGALAPTS NGSPGMSFGP HTYWGHLHLC THRHFPLKNF T

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Spleen EMBL BAD92820.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209583 mRNA. Translation: BAD92820.1.
IPI	IPI00914935.
RefSeq	NP_004564.2. NM_004573.2.
UniGene	Hs.355888.
3D structure databases
ProteinModelPortal	Q59F77.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59F77.
Protocols and materials databases
DNASU	5330.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5330.
KEGG	hsa:5330.
Organism-specific databases
CTD	5330.
PharmGKB	PA33385.
Phylogenomic databases
HOVERGEN	HBG053609.
KO	K05858.
Gene expression databases
ArrayExpress	Q59F77.
Bgee	Q59F77.
Family and domain databases
Gene3D	1.10.238.10. 1 hit. 3.20.20.190. 2 hits.
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011992. EF-hand-like_dom. IPR001192. Pinositol_PLipase_C. IPR017946. PLC-like_Pdiesterase_TIM-brl. IPR015359. PLipase_C_EF-hand-like. IPR000909. PLipase_C_PInositol-sp_X_dom. IPR001711. PLipase_C_Pinositol-sp_Y. [Graphical view]
PANTHER	PTHR10336. PTHR10336. 1 hit.
Pfam	PF00168. C2. 1 hit. PF09279. efhand_like. 1 hit. PF00388. PI-PLC-X. 1 hit. PF00387. PI-PLC-Y. 1 hit. [Graphical view]
PRINTS	PR00390. PHPHLIPASEC.
SMART	SM00239. C2. 1 hit. SM00148. PLCXc. 1 hit. SM00149. PLCYc. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF51695. PLC-like_Pdiesterase_TIM-brl. 1 hit.
PROSITE	PS50004. C2. 1 hit. PS50007. PIPLC_X_DOMAIN. 1 hit. PS50008. PIPLC_Y_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5330.
NextBio	20640.

Entry information

Entry name

Q59F77_HUMAN

Accession

Primary (citable) accession number: Q59F77

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.