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Q59F77 (Q59F77_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length901 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. RuleBase RU361133

Sequence similarities

Contains 1 C2 domain. RuleBase RU361133

Contains 1 PI-PLC X-box domain. RuleBase RU361133

Contains 1 PI-PLC Y-box domain. RuleBase RU361133

Contains C2 domain. SAAS SAAS015359

Contains Cdomain. SAAS SAAS015359

Contains PI-PLC X-box domain. SAAS SAAS015359

Contains PI-PLC Y-box domain. SAAS SAAS015359

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding3351Calcium PDB 2ZKM
Metal binding3641Calcium PDB 2ZKM
Metal binding3661Calcium PDB 2ZKM
Metal binding4151Calcium PDB 2ZKM

Experimental info

Non-terminal residue11 EMBL BAD92820.1

Sequences

Sequence LengthMass (Da)Tools
Q59F77 [UniParc].

Last modified April 26, 2005. Version 1.
Checksum: 8BFD658D0FA74529

FASTA901101,751
        10         20         30         40         50         60 
QRGTLGTMSL LNPVLLPPKV KAYLSQGERF IKWDDETTVA SPVILRVDPK GYYLYWTYQS 

        70         80         90        100        110        120 
KEMEFLDITS IRDTRFGKFA KMPKSQKLRD VFNMDFPDNS FLLKTLTVVS GPDMVDLTFH 

       130        140        150        160        170        180 
NFVSYKENVG KAWAEDVLAL VKHPLTANAS RSTFLDKILV KLKMQLNSEG KIPVKNFFQM 

       190        200        210        220        230        240 
FPADRKRVEA ALSACHLPKG KNDAINPEDF PEPVYKSFLM SLCPRPEIDE IFTSYHAKAK 

       250        260        270        280        290        300 
PYMTKEHLTK FINQKQRDSR LNSLLFPPAR PDQVQGLIDK YEPSGINAQR GQLSPEGMVW 

       310        320        330        340        350        360 
FLCGPENSVL AQDKLLLHHD MTQPLNHYFI NSSHNTYLTA GQFSGLSSAE MYRQVLLSGC 

       370        380        390        400        410        420 
RCVELDCWKG KPPDEEPIIT HGFTMTTDIF FKEAIEAIAE SAFKTSPYPI ILSFENHVDS 

       430        440        450        460        470        480 
PRQQAKMAEY CRTIFGDMLL TEPLEKFPLK PGVPLPSPED LRGKILIKNK KNQFSGPTSS 

       490        500        510        520        530        540 
SKDTGGEAEG SSPPSAPAGE GTVWAGEEGT ELEEEEVEEE EEEESGNLDE EEIKKMQSDE 

       550        560        570        580        590        600 
GTAGLEVTAY EEMSSLVNYI QPTKFVSFEF SAQKNRSYVI SSFTELKAYD LLSKASVQFV 

       610        620        630        640        650        660 
DYNKRQMSRI YPKGTRMDSS NYMPQMFWNA GCQMVALNFQ TMDLPMQQNM AVFEFNGQSG 

       670        680        690        700        710        720 
YLLKHEFMRR PDKQFNPFSV DRIDVVVATT LSITVISGQF LSERSVRTYV EVELFGLPGD 

       730        740        750        760        770        780 
PKRRYRTKLS PSTNSINPVW KEEPFVFEKI LMPELASLRV AVMEEGNKFL GHRIIPINAL 

       790        800        810        820        830        840 
NSGYHHLCLH SESNMPLTMP ALFIFLEMKD YIPGAWADLT VALANPIKFF SAHDTKSVKL 

       850        860        870        880        890        900 
KEAMGGLPEK PFPLASPVAS QVNGALAPTS NGSPGMSFGP HTYWGHLHLC THRHFPLKNF 


T 

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References

[1]"Homo sapiens protein coding cDNA."
Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Spleen EMBL BAD92820.1.
[2]"General and versatile autoinhibition of PLC isozymes."
Hicks S.N., Jezyk M.R., Gershburg S., Seifert J.P., Harden T.K., Sondek J.
Mol. Cell 31:383-394(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 8-810 IN COMPLEX WITH CALCIUM.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB209583 mRNA. Translation: BAD92820.1.
RefSeqNP_001271226.1. NM_001284297.1.
NP_001271227.1. NM_001284298.1.
NP_004564.2. NM_004573.2.
UniGeneHs.355888.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKMX-ray1.62X8-810[»]
ProteinModelPortalQ59F77.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

DNASU5330.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5330.
KEGGhsa:5330.

Organism-specific databases

CTD5330.
PharmGKBPA33385.

Phylogenomic databases

HOVERGENHBG053609.
KOK05858.

Gene expression databases

ArrayExpressQ59F77.
BgeeQ59F77.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR028403. PLC-beta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
PfamPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSPR00390. PHPHLIPASEC.
SMARTSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi5330.
NextBio20640.

Entry information

Entry nameQ59F77_HUMAN
AccessionPrimary (citable) accession number: Q59F77
Entry history
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 9, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.