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Q59F77

- Q59F77_HUMAN

UniProt

Q59F77 - Q59F77_HUMAN

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Protein

Phosphoinositide phospholipase C

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi335 – 3351CalciumImported
Metal bindingi364 – 3641CalciumImported
Metal bindingi366 – 3661CalciumImported
Metal bindingi415 – 4151CalciumImported

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33385.

Expressioni

Gene expression databases

BgeeiQ59F77.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKMX-ray1.62X8-810[»]
ProteinModelPortaliQ59F77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation
Contains C2 domain.SAAS annotation
Contains Cdomain.SAAS annotation
Contains PI-PLC X-box domain.SAAS annotation
Contains PI-PLC Y-box domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG053609.
KOiK05858.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR028403. PLC-beta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59F77-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
QRGTLGTMSL LNPVLLPPKV KAYLSQGERF IKWDDETTVA SPVILRVDPK
60 70 80 90 100
GYYLYWTYQS KEMEFLDITS IRDTRFGKFA KMPKSQKLRD VFNMDFPDNS
110 120 130 140 150
FLLKTLTVVS GPDMVDLTFH NFVSYKENVG KAWAEDVLAL VKHPLTANAS
160 170 180 190 200
RSTFLDKILV KLKMQLNSEG KIPVKNFFQM FPADRKRVEA ALSACHLPKG
210 220 230 240 250
KNDAINPEDF PEPVYKSFLM SLCPRPEIDE IFTSYHAKAK PYMTKEHLTK
260 270 280 290 300
FINQKQRDSR LNSLLFPPAR PDQVQGLIDK YEPSGINAQR GQLSPEGMVW
310 320 330 340 350
FLCGPENSVL AQDKLLLHHD MTQPLNHYFI NSSHNTYLTA GQFSGLSSAE
360 370 380 390 400
MYRQVLLSGC RCVELDCWKG KPPDEEPIIT HGFTMTTDIF FKEAIEAIAE
410 420 430 440 450
SAFKTSPYPI ILSFENHVDS PRQQAKMAEY CRTIFGDMLL TEPLEKFPLK
460 470 480 490 500
PGVPLPSPED LRGKILIKNK KNQFSGPTSS SKDTGGEAEG SSPPSAPAGE
510 520 530 540 550
GTVWAGEEGT ELEEEEVEEE EEEESGNLDE EEIKKMQSDE GTAGLEVTAY
560 570 580 590 600
EEMSSLVNYI QPTKFVSFEF SAQKNRSYVI SSFTELKAYD LLSKASVQFV
610 620 630 640 650
DYNKRQMSRI YPKGTRMDSS NYMPQMFWNA GCQMVALNFQ TMDLPMQQNM
660 670 680 690 700
AVFEFNGQSG YLLKHEFMRR PDKQFNPFSV DRIDVVVATT LSITVISGQF
710 720 730 740 750
LSERSVRTYV EVELFGLPGD PKRRYRTKLS PSTNSINPVW KEEPFVFEKI
760 770 780 790 800
LMPELASLRV AVMEEGNKFL GHRIIPINAL NSGYHHLCLH SESNMPLTMP
810 820 830 840 850
ALFIFLEMKD YIPGAWADLT VALANPIKFF SAHDTKSVKL KEAMGGLPEK
860 870 880 890 900
PFPLASPVAS QVNGALAPTS NGSPGMSFGP HTYWGHLHLC THRHFPLKNF

T
Length:901
Mass (Da):101,751
Last modified:April 26, 2005 - v1
Checksum:i8BFD658D0FA74529
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209583 mRNA. Translation: BAD92820.1.
RefSeqiNP_001271226.1. NM_001284297.1.
NP_001271227.1. NM_001284298.1.
NP_004564.2. NM_004573.2.
UniGeneiHs.355888.

Genome annotation databases

GeneIDi5330.
KEGGihsa:5330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209583 mRNA. Translation: BAD92820.1 .
RefSeqi NP_001271226.1. NM_001284297.1.
NP_001271227.1. NM_001284298.1.
NP_004564.2. NM_004573.2.
UniGenei Hs.355888.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ZKM X-ray 1.62 X 8-810 [» ]
ProteinModelPortali Q59F77.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 5330.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5330.
KEGGi hsa:5330.

Organism-specific databases

CTDi 5330.
PharmGKBi PA33385.

Phylogenomic databases

HOVERGENi HBG053609.
KOi K05858.

Miscellaneous databases

GenomeRNAii 5330.
NextBioi 20640.

Gene expression databases

Bgeei Q59F77.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR028403. PLC-beta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
Pfami PF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 8-810 IN COMPLEX WITH CALCIUM.

Entry informationi

Entry nameiQ59F77_HUMAN
AccessioniPrimary (citable) accession number: Q59F77
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3