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Q59F77

- Q59F77_HUMAN

UniProt

Q59F77 - Q59F77_HUMAN

Protein

Phosphoinositide phospholipase C

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi335 – 3351CalciumImported
    Metal bindingi364 – 3641CalciumImported
    Metal bindingi366 – 3661CalciumImported
    Metal bindingi415 – 4151CalciumImported

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
    3. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    HydrolaseUniRule annotation, TransducerSAAS annotation

    Keywords - Biological processi

    Lipid degradationUniRule annotation, Lipid metabolism

    Keywords - Ligandi

    CalciumImported, Metal-bindingImported

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33385.

    Expressioni

    Gene expression databases

    ArrayExpressiQ59F77.
    BgeeiQ59F77.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ZKMX-ray1.62X8-810[»]
    ProteinModelPortaliQ59F77.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 C2 domain.UniRule annotation
    Contains 1 PI-PLC X-box domain.UniRule annotation
    Contains 1 PI-PLC Y-box domain.UniRule annotation
    Contains C2 domain.SAAS annotation
    Contains PI-PLC X-box domain.SAAS annotation
    Contains PI-PLC Y-box domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG053609.
    KOiK05858.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR028403. PLC-beta2.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF10. PTHR10336:SF10. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view]
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEiPS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q59F77-1 [UniParc]FASTAAdd to Basket

    « Hide

    QRGTLGTMSL LNPVLLPPKV KAYLSQGERF IKWDDETTVA SPVILRVDPK    50
    GYYLYWTYQS KEMEFLDITS IRDTRFGKFA KMPKSQKLRD VFNMDFPDNS 100
    FLLKTLTVVS GPDMVDLTFH NFVSYKENVG KAWAEDVLAL VKHPLTANAS 150
    RSTFLDKILV KLKMQLNSEG KIPVKNFFQM FPADRKRVEA ALSACHLPKG 200
    KNDAINPEDF PEPVYKSFLM SLCPRPEIDE IFTSYHAKAK PYMTKEHLTK 250
    FINQKQRDSR LNSLLFPPAR PDQVQGLIDK YEPSGINAQR GQLSPEGMVW 300
    FLCGPENSVL AQDKLLLHHD MTQPLNHYFI NSSHNTYLTA GQFSGLSSAE 350
    MYRQVLLSGC RCVELDCWKG KPPDEEPIIT HGFTMTTDIF FKEAIEAIAE 400
    SAFKTSPYPI ILSFENHVDS PRQQAKMAEY CRTIFGDMLL TEPLEKFPLK 450
    PGVPLPSPED LRGKILIKNK KNQFSGPTSS SKDTGGEAEG SSPPSAPAGE 500
    GTVWAGEEGT ELEEEEVEEE EEEESGNLDE EEIKKMQSDE GTAGLEVTAY 550
    EEMSSLVNYI QPTKFVSFEF SAQKNRSYVI SSFTELKAYD LLSKASVQFV 600
    DYNKRQMSRI YPKGTRMDSS NYMPQMFWNA GCQMVALNFQ TMDLPMQQNM 650
    AVFEFNGQSG YLLKHEFMRR PDKQFNPFSV DRIDVVVATT LSITVISGQF 700
    LSERSVRTYV EVELFGLPGD PKRRYRTKLS PSTNSINPVW KEEPFVFEKI 750
    LMPELASLRV AVMEEGNKFL GHRIIPINAL NSGYHHLCLH SESNMPLTMP 800
    ALFIFLEMKD YIPGAWADLT VALANPIKFF SAHDTKSVKL KEAMGGLPEK 850
    PFPLASPVAS QVNGALAPTS NGSPGMSFGP HTYWGHLHLC THRHFPLKNF 900
    T 901
    Length:901
    Mass (Da):101,751
    Last modified:April 26, 2005 - v1
    Checksum:i8BFD658D0FA74529
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209583 mRNA. Translation: BAD92820.1.
    RefSeqiNP_001271226.1. NM_001284297.1.
    NP_001271227.1. NM_001284298.1.
    NP_004564.2. NM_004573.2.
    UniGeneiHs.355888.

    Genome annotation databases

    GeneIDi5330.
    KEGGihsa:5330.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209583 mRNA. Translation: BAD92820.1 .
    RefSeqi NP_001271226.1. NM_001284297.1.
    NP_001271227.1. NM_001284298.1.
    NP_004564.2. NM_004573.2.
    UniGenei Hs.355888.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ZKM X-ray 1.62 X 8-810 [» ]
    ProteinModelPortali Q59F77.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 5330.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5330.
    KEGGi hsa:5330.

    Organism-specific databases

    CTDi 5330.
    PharmGKBi PA33385.

    Phylogenomic databases

    HOVERGENi HBG053609.
    KOi K05858.

    Miscellaneous databases

    GenomeRNAii 5330.
    NextBioi 20640.

    Gene expression databases

    ArrayExpressi Q59F77.
    Bgeei Q59F77.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    2.60.40.150. 1 hit.
    3.20.20.190. 2 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR028403. PLC-beta2.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF10. PTHR10336:SF10. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    [Graphical view ]
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 1 hit.
    PROSITEi PS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: SpleenImported.
    2. Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 8-810 IN COMPLEX WITH CALCIUM.

    Entry informationi

    Entry nameiQ59F77_HUMAN
    AccessioniPrimary (citable) accession number: Q59F77
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3