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Protein

Phosphoinositide phospholipase C

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi335 – 3351CalciumCombined sources
Metal bindingi364 – 3641CalciumCombined sources
Metal bindingi366 – 3661CalciumCombined sources
Metal bindingi415 – 4151CalciumCombined sources

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  3. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. lipid catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotation, TransducerSAAS annotation

Keywords - Biological processi

Lipid degradationUniRule annotation, Lipid metabolism

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33385.

Expressioni

Gene expression databases

BgeeiQ59F77.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKMX-ray1.62X8-810[»]
ProteinModelPortaliQ59F77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2 domain.UniRule annotation
Contains 1 PI-PLC X-box domain.UniRule annotation
Contains 1 PI-PLC Y-box domain.UniRule annotation

Phylogenomic databases

HOVERGENiHBG053609.
KOiK05858.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59F77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QRGTLGTMSL LNPVLLPPKV KAYLSQGERF IKWDDETTVA SPVILRVDPK
60 70 80 90 100
GYYLYWTYQS KEMEFLDITS IRDTRFGKFA KMPKSQKLRD VFNMDFPDNS
110 120 130 140 150
FLLKTLTVVS GPDMVDLTFH NFVSYKENVG KAWAEDVLAL VKHPLTANAS
160 170 180 190 200
RSTFLDKILV KLKMQLNSEG KIPVKNFFQM FPADRKRVEA ALSACHLPKG
210 220 230 240 250
KNDAINPEDF PEPVYKSFLM SLCPRPEIDE IFTSYHAKAK PYMTKEHLTK
260 270 280 290 300
FINQKQRDSR LNSLLFPPAR PDQVQGLIDK YEPSGINAQR GQLSPEGMVW
310 320 330 340 350
FLCGPENSVL AQDKLLLHHD MTQPLNHYFI NSSHNTYLTA GQFSGLSSAE
360 370 380 390 400
MYRQVLLSGC RCVELDCWKG KPPDEEPIIT HGFTMTTDIF FKEAIEAIAE
410 420 430 440 450
SAFKTSPYPI ILSFENHVDS PRQQAKMAEY CRTIFGDMLL TEPLEKFPLK
460 470 480 490 500
PGVPLPSPED LRGKILIKNK KNQFSGPTSS SKDTGGEAEG SSPPSAPAGE
510 520 530 540 550
GTVWAGEEGT ELEEEEVEEE EEEESGNLDE EEIKKMQSDE GTAGLEVTAY
560 570 580 590 600
EEMSSLVNYI QPTKFVSFEF SAQKNRSYVI SSFTELKAYD LLSKASVQFV
610 620 630 640 650
DYNKRQMSRI YPKGTRMDSS NYMPQMFWNA GCQMVALNFQ TMDLPMQQNM
660 670 680 690 700
AVFEFNGQSG YLLKHEFMRR PDKQFNPFSV DRIDVVVATT LSITVISGQF
710 720 730 740 750
LSERSVRTYV EVELFGLPGD PKRRYRTKLS PSTNSINPVW KEEPFVFEKI
760 770 780 790 800
LMPELASLRV AVMEEGNKFL GHRIIPINAL NSGYHHLCLH SESNMPLTMP
810 820 830 840 850
ALFIFLEMKD YIPGAWADLT VALANPIKFF SAHDTKSVKL KEAMGGLPEK
860 870 880 890 900
PFPLASPVAS QVNGALAPTS NGSPGMSFGP HTYWGHLHLC THRHFPLKNF

T
Length:901
Mass (Da):101,751
Last modified:April 26, 2005 - v1
Checksum:i8BFD658D0FA74529
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209583 mRNA. Translation: BAD92820.1.
RefSeqiNP_001271226.1. NM_001284297.1.
NP_001271227.1. NM_001284298.1.
NP_004564.2. NM_004573.2.
UniGeneiHs.355888.

Genome annotation databases

GeneIDi5330.
KEGGihsa:5330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209583 mRNA. Translation: BAD92820.1.
RefSeqiNP_001271226.1. NM_001284297.1.
NP_001271227.1. NM_001284298.1.
NP_004564.2. NM_004573.2.
UniGeneiHs.355888.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZKMX-ray1.62X8-810[»]
ProteinModelPortaliQ59F77.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi5330.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5330.
KEGGihsa:5330.

Organism-specific databases

CTDi5330.
PharmGKBiPA33385.

Phylogenomic databases

HOVERGENiHBG053609.
KOiK05858.

Miscellaneous databases

GenomeRNAii5330.
NextBioi20640.

Gene expression databases

BgeeiQ59F77.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR028403. PLC-beta2.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF10. PTHR10336:SF10. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 8-810 IN COMPLEX WITH CALCIUM.

Entry informationi

Entry nameiQ59F77_HUMAN
AccessioniPrimary (citable) accession number: Q59F77
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 29, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.