Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Fibroblast growth factor receptor 4 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorSAAS annotationImported, Transferase, Tyrosine-protein kinaseSAAS annotation

Keywords - Ligandi

ATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Fibroblast growth factor receptor 4 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei497 – 52024HelicalSequence analysisAdd
BLAST
Transmembranei602 – 62221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiQ59F30.
PeptideAtlasiQ59F30.
PRIDEiQ59F30.

PTM databases

iPTMnetiQ59F30.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000292408.

Structurei

3D structure databases

ProteinModelPortaliQ59F30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini267 – 35589Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini364 – 464101Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST
Domaini699 – 987289Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000263410.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59F30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PCMWHQQHVP CVCVCPYVCV CMRVCVCVCV SWPLSCALNA VCVTCPKSVA
60 70 80 90 100
FALGVASAAC GCVGVKEWWL LQHALRSACA LHVRCVLCTQ EAASDGAAGS
110 120 130 140 150
ADLCPLPTEP CLAPSLEQQE QELTVALGQP VRLCCGRAER GGHWYKEGSR
160 170 180 190 200
LAPAGRVRGW RGRLEIASFL PEDAGRYLCL ARGSMIVLQN LTLITGDSLP
210 220 230 240 250
PATMMRTPSP IGTSRIGTVT PSKVSRSPRT CVPAAAHLIT EKRRPVWEHT
260 270 280 290 300
VILGAFPCPP APYWTHPQRM EKKLHAVPAG NTVKFRCPAA GNPTPTIRWL
310 320 330 340 350
KDGQAFHGEN RIGGIRLRHQ HWSLVMESVV PSDRGTYTCL VENAVGSIRY
360 370 380 390 400
NYLLDVLERS PHRPILQAGL PANTTAVVGS DVELLCKVYS DAQPHIQWLK
410 420 430 440 450
HIVINGSSFG ADGFPYVQVL KTADINSSEV EVLYLRNVSA EDAGEYTCLA
460 470 480 490 500
GNSIGLSYQS AWLTVLPGEH LKGQEMLRDA PLGQQWGLWP VGWSVSVGLW
510 520 530 540 550
GLAWGAVCGF VGLSCMTAPL CLSTRGRPCD RLLRCGCLGL GITTASSVCV
560 570 580 590 600
PTYVGSWEGL SGCTGRPVSP LTSLSVCVCP CARAEEDPTW TAAAPEARYT
610 620 630 640 650
DIILYASGSL ALAVLLLLAR LYRGQALHGR HPRPPATVQK LSRFPLARQF
660 670 680 690 700
SLESGSSGKS SSSLVRGVRL SSSGPALLAG LVSLDLPLDP LWEFPRDRLV
710 720 730 740 750
LGKPLGEGCF GQVVRAEAFG MDPARPDQAS TVAVKMLKDN ASDKDLADLV
760 770 780 790 800
SEMEVMKLIG RHKNIINLLG VCTQEGPLYV IVECAAKGNL REFLRARRPP
810 820 830 840 850
GPDLSPDGPR SSEGPLSFPV LVSCAYQVAR GMQYLESRKC IHRDLAARNV
860 870 880 890 900
LVTEDNVMKI ADFGLARGVH HIDYYKKTSN GRLPVKWMAP EALFDRVYTH
910 920 930 940 950
QSDVWSFGIL LWEIFTLGGS PYPGIPVEEL FSLLREGHRM DRPPHCPPEL
960 970 980 990 1000
YGLMRECWHA APSQRPTFKQ LVEALDKVLL AVSEEYLDLR LTFGPYSPSG
1010 1020 1030
GDASSTCSSS DSVFSHDPLP LGSSSFPFGS GVQT
Length:1,034
Mass (Da):112,165
Last modified:April 26, 2005 - v1
Checksum:iE6E8BD6D25EEE7BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209631 Transcribed RNA. Translation: BAD92868.1.
UniGeneiHs.165950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209631 Transcribed RNA. Translation: BAD92868.1.
UniGeneiHs.165950.

3D structure databases

ProteinModelPortaliQ59F30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000292408.

PTM databases

iPTMnetiQ59F30.

Proteomic databases

PaxDbiQ59F30.
PeptideAtlasiQ59F30.
PRIDEiQ59F30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000263410.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50835. IG_LIKE. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ59F30_HUMAN
AccessioniPrimary (citable) accession number: Q59F30
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.