Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Neuropilin-1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi162 – 1621CalciumUniRule annotation
Metal bindingi176 – 1761CalciumUniRule annotation
Metal bindingi217 – 2171CalciumUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neuropilin-1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei824 – 84926HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31783.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 71UniRule annotation
Disulfide bondi114 ↔ 140UniRule annotation
Disulfide bondi173 ↔ 195UniRule annotation
Disulfide bondi242 ↔ 391UniRule annotation
Disulfide bondi398 ↔ 550UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiQ59F20.
PeptideAtlasiQ59F20.
PRIDEiQ59F20.

Expressioni

Gene expression databases

GenevisibleiQ59F20. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000265371.

Structurei

3D structure databases

ProteinModelPortaliQ59F20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 108108CUBInterPro annotationAdd
BLAST
Domaini114 – 232119CUBInterPro annotationAdd
BLAST
Domaini242 – 391150F5/8 type CInterPro annotationAdd
BLAST
Domaini398 – 550153F5/8 type CInterPro annotationAdd
BLAST
Domaini615 – 778164MAMInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 2 F5/8 type C domains.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IE8T. Eukaryota.
ENOG410YRBE. LUCA.
HOVERGENiHBG000502.
KOiK06724.

Family and domain databases

CDDicd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF654. PTHR10127:SF654. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59F20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KPQGYLTSPG YPHSYHPSEK CEWLIQAPDP YQRIMINFNP HFDLEDRDCK
60 70 80 90 100
YDYVEVFDGE NENGHFRGKF CGKIAPPPVV SSGPFLFIKF VSDYETHGAG
110 120 130 140 150
FSIRYEIFKR GPECSQNYTT PSGVIKSPGF PEKYPNSLEC TYIVFAPKMS
160 170 180 190 200
EIILEFESFD LEPDSNPPGG MFCRYDRLEI WDGFPDVGPH IGRYCGQKTP
210 220 230 240 250
GRIRSSSGIL SMVFYTDSAI AKEGFSANYS VLQSSVSEDF KCMEALGMES
260 270 280 290 300
GEIHSDQITA SSQYSTNWSA ERSRLNYPEN GWTPGEDSYR EWIQVDLGLL
310 320 330 340 350
RFVTAVGTQG AISKETKKKY YVKTYKIDVS SNGEDWITIK EGNKPVLFQG
360 370 380 390 400
NTNPTDVVVA VFPKPLITRF VRIKPATWET GISMRFEVYG CKITDYPCSG
410 420 430 440 450
MLGMVSGLIS DSQITSSNQG DRNWMPENIR LVTSRSGWAL PPAPHSYINE
460 470 480 490 500
WLQIDLGEEK IVRGIIIQGG KHRENKVFMR KFKIGYSNNG SDWKMIMDDS
510 520 530 540 550
KRKAKSFEGN NNYDTPELRT FPALSTRFIR IYPERATHGG LGLRMELLGC
560 570 580 590 600
EVEAPTAGPT TPNGNLVDEC DDDQANCHSG TGDDFQLTGG TTVLATEKPT
610 620 630 640 650
VIDSTIQSEF PTYGFNCEFG WGSHKTFCHW EHDNHVQLKW SVLTSKTGPI
660 670 680 690 700
QDHTGDGNFI YSQADENQKG KVARLVSPVV YSQNSAHCMT FWYHMSGSHV
710 720 730 740 750
GTLRVKLRYQ KPEEYDQLVW MAIGHQGDHW KEGRVLLHKS LKLYQVIFEG
760 770 780 790 800
EIGKGNLGGI AVDDISINNH ISQEDCAKPA DLDKKNPEIK IDETGSTPGY
810 820 830 840 850
EGEGEGDKNI SRKPGNVLKT LDPILITIIA MSALGVLLGA VCGVVLYCAC
860 870 880 890
WHNGMSERNL SALENYNFEL VDGVKLKKDK LNTQSTYSEA
Length:890
Mass (Da):99,694
Last modified:April 26, 2005 - v1
Checksum:iCAA6CE38A97288CB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209641 mRNA. Translation: BAD92878.1.
RefSeqiNP_001231901.1. NM_001244972.1.
NP_001231902.1. NM_001244973.1.
NP_003864.4. NM_003873.5.
UniGeneiHs.131704.
Hs.653996.

Genome annotation databases

GeneIDi8829.
KEGGihsa:8829.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209641 mRNA. Translation: BAD92878.1.
RefSeqiNP_001231901.1. NM_001244972.1.
NP_001231902.1. NM_001244973.1.
NP_003864.4. NM_003873.5.
UniGeneiHs.131704.
Hs.653996.

3D structure databases

ProteinModelPortaliQ59F20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000265371.

Proteomic databases

PaxDbiQ59F20.
PeptideAtlasiQ59F20.
PRIDEiQ59F20.

Protocols and materials databases

DNASUi8829.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8829.
KEGGihsa:8829.

Organism-specific databases

CTDi8829.
PharmGKBiPA31783.

Phylogenomic databases

eggNOGiENOG410IE8T. Eukaryota.
ENOG410YRBE. LUCA.
HOVERGENiHBG000502.
KOiK06724.

Miscellaneous databases

GenomeRNAii8829.

Gene expression databases

GenevisibleiQ59F20. HS.

Family and domain databases

CDDicd06263. MAM. 1 hit.
Gene3Di2.60.120.260. 2 hits.
2.60.120.290. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR000859. CUB_dom.
IPR000421. FA58C.
IPR008979. Galactose-bd-like.
IPR000998. MAM_dom.
IPR014648. Neuropilin.
IPR022579. Neuropilin_C.
IPR027146. NRP1.
[Graphical view]
PANTHERiPTHR10127:SF654. PTHR10127:SF654. 1 hit.
PfamiPF00431. CUB. 2 hits.
PF11980. DUF3481. 1 hit.
PF00754. F5_F8_type_C. 2 hits.
PF00629. MAM. 1 hit.
[Graphical view]
PIRSFiPIRSF036960. Neuropilin. 1 hit.
PRINTSiPR00020. MAMDOMAIN.
SMARTiSM00042. CUB. 2 hits.
SM00231. FA58C. 2 hits.
SM00137. MAM. 1 hit.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 2 hits.
SSF49854. SSF49854. 2 hits.
SSF49899. SSF49899. 1 hit.
PROSITEiPS01180. CUB. 2 hits.
PS01285. FA58C_1. 2 hits.
PS01286. FA58C_2. 2 hits.
PS50022. FA58C_3. 2 hits.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ59F20_HUMAN
AccessioniPrimary (citable) accession number: Q59F20
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.