ID   Q59F19_HUMAN            Unreviewed;       949 AA.
AC   Q59F19;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   27-MAR-2024, entry version 105.
DE   SubName: Full=Proto-oncogene tyrosine-protein kinase ABL1 variant {ECO:0000313|EMBL:BAD92879.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92879.1};
RN   [1] {ECO:0000313|EMBL:BAD92879.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:BAD92879.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AB209642; BAD92879.1; -; mRNA.
DR   AlphaFoldDB; Q59F19; -.
DR   PeptideAtlas; Q59F19; -.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05052; PTKc_Abl; 1.
DR   Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR015015; F-actin-binding.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   PANTHER; PTHR24418; TYROSINE-PROTEIN KINASE; 1.
DR   PANTHER; PTHR24418:SF438; TYROSINE-PROTEIN KINASE ABL1; 1.
DR   Pfam; PF08919; F_actin_bind; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00808; FABD; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Kinase {ECO:0000313|EMBL:BAD92879.1};
KW   Transferase {ECO:0000313|EMBL:BAD92879.1}.
FT   DOMAIN          61..312
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          15..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..815
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        352..368
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        398..420
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..457
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        504..522
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        554..572
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..591
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        689..713
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92879.1"
SQ   SEQUENCE   949 AA;  102591 MW;  219200BE06EBCEEA CRC64;
     WQALRLLREP LQHPGRVGSS SFNGGRRAHH HAPLSSPKAQ QAHCLWCVPQ LRQVGDGTHG
     HHHEAQAGGG QYGEVYEGVW KKYSLTVAVK TLKEDTMEVE EFLKEAAVMK EIKHPNLVQL
     LGVCTREPPF YIITEFMTYG NLLDYLRECN RQEVNAVVLL YMATQISSAM EYLEKKNFIH
     RDLAARNCLV GENHLVKVAD FGLSRLMTGD TYTAHAGAKF PIKWTAPESL AYNKFSIKSD
     VWAFGVLLWE IATYGMSPYP GIDLSQVYEL LEKDYRMERP EGCPEKVYEL MRACWQWNPS
     DRPSFAEIHQ AFETMFQESS ISDEVEKELG KQGVRGAVST LLQAPELPTK TRTSRRAAEH
     RDTTDVPEMP HSKGQGESDP LDHEPAVSPL LPRKERGPPE GGLNEDERLL PKDKKTNLFS
     ALIKKKKKTA PTPPKRSSSF REMDGQPERR GAGEEEGRDI SNGALAFTPL DTADPAKSPK
     PSNGAGVPNG ALRESGGSGF RSPHLWKKSS TLTSSRLATG EEEGGGSSSK RFLRSCSASC
     VPHGAKDTEW RSVTLPRDLQ STGRQFDSST FGGHKSEKPA LPRKRAGENR SDQVTRGTVT
     PPPRLVKKNE EAADEVFKDI MESSPGSSPP NLTPKPLRRQ VTVAPASGLP HKEEAGKGSA
     LGTPAAAEPV TPTSKAGSGA PGGTSKGPAE ESRVRRHKHS SESPGRDKGK LSRLKPAPPP
     PPAASAGKAG GKPSQSPSQE AAGEAVLGAK TKATSLVDAV NSDAAKPSQP GEGLKKPVLP
     ATPKPQSAKP SGTPISPAPV PSTLPSASSA LAGDQPSSTA FIPLISTRVS LRKTRQPPER
     IASGAITKGV VLDSTEALCL AISRNSEQMA SHSAVLEAGK NLYTFCVSYV DSIQQMRNKF
     AFREAINKLE NNLRELQICP ATAGSGPAAT QDFSKLLSSV KEISDIVQR
//