ID   Q59F15_HUMAN            Unreviewed;       847 AA.
AC   Q59F15;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=COL4A1 protein variant {ECO:0000313|EMBL:BAD92883.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD92883.1};
RN   [1] {ECO:0000313|EMBL:BAD92883.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Spleen {ECO:0000313|EMBL:BAD92883.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Type IV collagen is the major structural component of
CC       glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork
CC       together with laminins, proteoglycans and entactin/nidogen.
CC       {ECO:0000256|ARBA:ARBA00003696}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC       Secreted, extracellular space, extracellular matrix, basement membrane
CC       {ECO:0000256|ARBA:ARBA00004302}.
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DR   EMBL; AB209646; BAD92883.1; -; mRNA.
DR   AlphaFoldDB; Q59F15; -.
DR   PeptideAtlas; Q59F15; -.
DR   GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR   Gene3D; 2.170.240.10; Collagen IV, non-collagenous; 1.
DR   InterPro; IPR008160; Collagen.
DR   InterPro; IPR001442; Collagen_IV_NC.
DR   InterPro; IPR036954; Collagen_IV_NC_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR   PANTHER; PTHR24023:SF1100; FIBRILLAR COLLAGEN NC1 DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01413; C4; 2.
DR   Pfam; PF01391; Collagen; 8.
DR   SMART; SM00111; C4; 2.
DR   SUPFAM; SSF56436; C-type lectin-like; 2.
DR   PROSITE; PS51403; NC1_IV; 1.
PE   2: Evidence at transcript level;
KW   Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW   Collagen {ECO:0000256|ARBA:ARBA00023119};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW   Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW   Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT   DOMAIN          623..847
FT                   /note="Collagen IV NC1"
FT                   /evidence="ECO:0000259|PROSITE:PS51403"
FT   REGION          1..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          582..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        519..544
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..610
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD92883.1"
SQ   SEQUENCE   847 AA;  82979 MW;  3083068BDE54461F CRC64;
     YRRISGASRA TGTPGRNRFP RAARGQGLPG ITGQSGLPGL PGQQGAPGIP GFPGSKGEMG
     VMGTPGQPGS PGPVGAPGLP GEKGDHGFPG SSGPRGDPGL KGDKGDVGLP GKPGSMDKVD
     MGSMKGQKGD QGEKGQIGPI GEKGSRGDPG TPGVPGKDGQ AGQPGQPGPK GDPGISGTPG
     APGLPGPKGS VGGMGLPGTP GEKGVPGIPG PQGSPGLPGD KGAKGEKGQA GPPGIGIPGL
     RGEKGDQGIA GFPGSPGEKG EKGSIGIPGM PGSPGLKGSP GSVGYPGSPG LPGEKGDKGL
     PGLDGIPGVK GEAGLPGTPG PTGPAGQKGE PGSDGIPGSA GEKGEPGLPG RGFPGFPGAK
     GDKGSKGEVG FPGLAGSPGI PGSKGEQGFM GPPGPQGQPG LPGSPGHATE GPKGDRGPQG
     QPGLPGLPGP MGPPGLPGID GVKGDKGNPG WPGAPGVPGP KGDPGFQGMP GIGGSPGITG
     SKGDMGPPGV PGFQGPKGLP GLQGIKGDQG DHGVPGAKGL PGPPGPPGPY DIIKGEPGLP
     GPEGPPGLKG LQGLPGPKGQ QGVTGLVGIP GPPGIPGFDG APGQKGEMGP AGPTGPRGFP
     GPPGPDGLPG SMGPPGTPSV DHGFLVTRHS QTIDDPQCPS GTKILYHGYS LLYVQGNERA
     HGQDLGTAGS CLRKFSTMPF LFCNINNVCN FASRNDYSYW LSTPEPMPMS MAPITGENIR
     PFISRCAVCE APAMVMAVHS QTIQIPPCPS GWSSLWIGYS FVMHTSAGAE GSGQALASPG
     SCLEEFRSAP FIECHGRGTC NYYANAYSFW LATIERSEMF KKPTPSTLKA GELRTHVSRC
     QVCMRRT
//