Q59F09 (Q59F09_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Werner syndrome protein variant EMBL BAD92889.1
Organism	Homo sapiens (Human) EMBL BAD92889.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	842 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	DNA recombination Inferred from electronic annotation. Source: InterPro DNA repair Inferred from electronic annotation. Source: InterPro DNA replication Inferred from electronic annotation. Source: InterPro
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro ATP-dependent 3'-5' DNA helicase activity Inferred from electronic annotation. Source: InterPro nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92889.1

Sequences

	Sequence		Length	Mass (Da)
	Q59F09 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 3158215049E1DDE7	FASTA	842	94,842
	10 20 30 40 50 60 IGLVISPLIS LMEDQVLQLK MSNIPACFLG SAQSENVLTD IKLGKYRIVY VTPEYCSGNM 70 80 90 100 110 120 GLLQQLEADI GITLIAVDEA HCISEWGHDF RDSFRKLGSL KTALPMVPIV ALTATASSSI 130 140 150 160 170 180 REDIVRCLNL RNPQITCTGF DRPNLYLEVR RKTGNILQDL QPFLVKTSSH WEFEGPTIIY 190 200 210 220 230 240 CPSRKMTQQV TGELRKLNLS CGTYHAGMSF STRKDIHHRF VRDEIQCVIA TIAFGMGINK 250 260 270 280 290 300 ADIRQVIHYG APKDMESYYQ EIGRAGRDGL QSSCHVLWAP ADINLNRHLL TEIRNEKFRL 310 320 330 340 350 360 YKLKMMAKME KYLHSSRCRR QIILSHFEDK QVQKASLGIM GTEKCCDNCR SRLDHCYSMD 370 380 390 400 410 420 DSEDTSWDFG PQAFKLLSAV DILGEKFGIG LPILFLRGSN SQRLADQYRR HSLFGTGKDQ 430 440 450 460 470 480 TESWWKAFSR QLITEGFLVE VSRYNKFMKI CALTKKGRNW LHKANTESQS LILQANEELC 490 500 510 520 530 540 PKKLLLPSSK TVSSGTKEHC YNQVPVELST EKKSNLEKLY SYKPCDKISS GSNISKKSIM 550 560 570 580 590 600 VQSPEKAYSS SQPVISAQEQ ETQIVLYGKL VEARQKHANK MDVPPAILAT NKILVDMAKM 610 620 630 640 650 660 RPTTVENVKR IDGVSEGKAA MLAPLWEVIK HFCQTNSVQT DLFSSTKPQE EQKTSLVAKN 670 680 690 700 710 720 KICTLSQSMA ITYSLFQEKK MPLKSIAESR ILPLMTIGMH LSQAVKAGCP LDLERAGLTP 730 740 750 760 770 780 EVQKIIADVI RNPPVNSDMS KISLIRMLVP ENIDTYLIHM AIEILKHGPD SGLQPSRDVN 790 800 810 820 830 840 KRRCFPGSEE ICSSSKRSKE EVGINTETSS AERKRRLPVW FAKGSDTSKK LMDKTKRGGL FS

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Spleen EMBL BAD92889.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209652 mRNA. Translation: BAD92889.1.
IPI	IPI00029107.
RefSeq	NP_000544.2. NM_000553.4.
UniGene	Hs.632050.
3D structure databases
ProteinModelPortal	Q59F09.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59F09.
Proteomic databases
PRIDE	Q59F09.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7486.
KEGG	hsa:7486.
Organism-specific databases
CTD	7486.
PharmGKB	PA367.
Phylogenomic databases
HOVERGEN	HBG000325.
KO	K10900.
Gene expression databases
ArrayExpress	Q59F09.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 1.10.150.80. 1 hit.
InterPro	IPR011545. DNA/RNA_helicase_DEAD/DEAH_N. IPR004589. DNA_helicase_ATP-dep_RecQ. IPR014001. Helicase_ATP-bd. IPR001650. Helicase_C. IPR010997. HRDC-like. IPR002121. HRDC_dom. IPR018982. RQC_domain. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00270. DEAD. 1 hit. PF00271. Helicase_C. 1 hit. PF00570. HRDC. 1 hit. PF09382. RQC. 1 hit. [Graphical view]
SMART	SM00490. HELICc. 1 hit. SM00341. HRDC. 1 hit. SM00956. RQC. 1 hit. [Graphical view]
SUPFAM	SSF47819. HRDC_like. 1 hit.
TIGRFAMs	TIGR00614. recQ_fam. 1 hit.
PROSITE	PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50967. HRDC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	7486.
NextBio	29326.

Entry information

Entry name

Q59F09_HUMAN

Accession

Primary (citable) accession number: Q59F09

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.