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Q59F09

- Q59F09_HUMAN

UniProt

Q59F09 - Q59F09_HUMAN

Protein
Submitted name:

Werner syndrome protein variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. ATP-dependent 3'-5' DNA helicase activity Source: InterPro
    3. nucleic acid binding Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: InterPro
    2. DNA repair Source: InterPro
    3. DNA replication Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Werner syndrome protein variantImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA367.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ59F09.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59F09.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG000325.
    KOiK10900.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.80. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR004589. DNA_helicase_ATP-dep_RecQ.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR029491. Helicase_HTH.
    IPR010997. HRDC-like.
    IPR002121. HRDC_dom.
    IPR027417. P-loop_NTPase.
    IPR018982. RQC_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF00570. HRDC. 1 hit.
    PF14493. HTH_40. 1 hit.
    PF09382. RQC. 1 hit.
    [Graphical view]
    SMARTiSM00490. HELICc. 1 hit.
    SM00341. HRDC. 1 hit.
    SM00956. RQC. 1 hit.
    [Graphical view]
    SUPFAMiSSF47819. SSF47819. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00614. recQ_fam. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50967. HRDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q59F09-1 [UniParc]FASTAAdd to Basket

    « Hide

    IGLVISPLIS LMEDQVLQLK MSNIPACFLG SAQSENVLTD IKLGKYRIVY    50
    VTPEYCSGNM GLLQQLEADI GITLIAVDEA HCISEWGHDF RDSFRKLGSL 100
    KTALPMVPIV ALTATASSSI REDIVRCLNL RNPQITCTGF DRPNLYLEVR 150
    RKTGNILQDL QPFLVKTSSH WEFEGPTIIY CPSRKMTQQV TGELRKLNLS 200
    CGTYHAGMSF STRKDIHHRF VRDEIQCVIA TIAFGMGINK ADIRQVIHYG 250
    APKDMESYYQ EIGRAGRDGL QSSCHVLWAP ADINLNRHLL TEIRNEKFRL 300
    YKLKMMAKME KYLHSSRCRR QIILSHFEDK QVQKASLGIM GTEKCCDNCR 350
    SRLDHCYSMD DSEDTSWDFG PQAFKLLSAV DILGEKFGIG LPILFLRGSN 400
    SQRLADQYRR HSLFGTGKDQ TESWWKAFSR QLITEGFLVE VSRYNKFMKI 450
    CALTKKGRNW LHKANTESQS LILQANEELC PKKLLLPSSK TVSSGTKEHC 500
    YNQVPVELST EKKSNLEKLY SYKPCDKISS GSNISKKSIM VQSPEKAYSS 550
    SQPVISAQEQ ETQIVLYGKL VEARQKHANK MDVPPAILAT NKILVDMAKM 600
    RPTTVENVKR IDGVSEGKAA MLAPLWEVIK HFCQTNSVQT DLFSSTKPQE 650
    EQKTSLVAKN KICTLSQSMA ITYSLFQEKK MPLKSIAESR ILPLMTIGMH 700
    LSQAVKAGCP LDLERAGLTP EVQKIIADVI RNPPVNSDMS KISLIRMLVP 750
    ENIDTYLIHM AIEILKHGPD SGLQPSRDVN KRRCFPGSEE ICSSSKRSKE 800
    EVGINTETSS AERKRRLPVW FAKGSDTSKK LMDKTKRGGL FS 842
    Length:842
    Mass (Da):94,842
    Last modified:April 26, 2005 - v1
    Checksum:i3158215049E1DDE7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209652 mRNA. Translation: BAD92889.1.
    RefSeqiNP_000544.2. NM_000553.4.
    UniGeneiHs.632050.

    Genome annotation databases

    GeneIDi7486.
    KEGGihsa:7486.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209652 mRNA. Translation: BAD92889.1 .
    RefSeqi NP_000544.2. NM_000553.4.
    UniGenei Hs.632050.

    3D structure databases

    ProteinModelPortali Q59F09.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q59F09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7486.
    KEGGi hsa:7486.

    Organism-specific databases

    CTDi 7486.
    PharmGKBi PA367.

    Phylogenomic databases

    HOVERGENi HBG000325.
    KOi K10900.

    Miscellaneous databases

    GenomeRNAii 7486.
    NextBioi 29326.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.80. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR004589. DNA_helicase_ATP-dep_RecQ.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR029491. Helicase_HTH.
    IPR010997. HRDC-like.
    IPR002121. HRDC_dom.
    IPR027417. P-loop_NTPase.
    IPR018982. RQC_domain.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF00570. HRDC. 1 hit.
    PF14493. HTH_40. 1 hit.
    PF09382. RQC. 1 hit.
    [Graphical view ]
    SMARTi SM00490. HELICc. 1 hit.
    SM00341. HRDC. 1 hit.
    SM00956. RQC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47819. SSF47819. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00614. recQ_fam. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50967. HRDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: SpleenImported.

    Entry informationi

    Entry nameiQ59F09_HUMAN
    AccessioniPrimary (citable) accession number: Q59F09
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.