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Protein
Submitted name:

Platelet-derived growth factor receptor beta variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei497 – 4971Proton acceptorUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Platelet-derived growth factor receptor beta variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei203 – 22725HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33148.

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Proteomic databases

PaxDbiQ59F04.
PeptideAtlasiQ59F04.
PRIDEiQ59F04.

Expressioni

Gene expression databases

GenevisibleiQ59F04. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000261799.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini271 – 633363Protein kinaseInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG004335.
KOiK05089.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR027288. PGFRB.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PANTHERiPTHR24416:SF53. PTHR24416:SF53. 2 hits.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59F04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AASEPDTAGS VRGLPTAHCP VVQDNRTLGD SSAGEIALST RNVSETRYVS
60 70 80 90 100
ELTLVRVKVA EAGHYTMRAF HEDAEVQLSF QLQINVPVRV LELSESHPDS
110 120 130 140 150
GEQTVRCRGR GMPQPNIIWS ACRDLKRCPR ELPPTLLGNS SEEESQLETN
160 170 180 190 200
VTYWEEEQEF EVVSTLRLQH VDRPLSVRCT LRNAVGQDTQ EVIVVPHSLP
210 220 230 240 250
FKVVVISAIL ALVVLTIISL IILIMLWQKK PRYEIRWKVI ESVSSDGHEY
260 270 280 290 300
IYVDPMQLPY DSTWELPRDQ LVLGRTLGSG AFGQVVEATA HGLSHSQATM
310 320 330 340 350
KVAVKMLKST ARSSEKQALM SELKIMSHLG PHLNVVNLLG ACTKGGPIYI
360 370 380 390 400
ITEYCRYGDL VDYLHRNKHT FLQHHSDKRR PPSAELYSNA LPVGLPLPSH
410 420 430 440 450
VSLTGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV
460 470 480 490 500
PSAPERTCRA TLINESPVLS YMDLVGFSYQ VANGMEFLAS KNCVHRDLAA
510 520 530 540 550
RNVLICEGKL VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL
560 570 580 590 600
YTTLSDVWSF GILLWEIFTL GGTPYPELPM NEQFYNAIKR GYRMAQPAHA
610 620 630 640 650
SDEIYEIMQK CWEEKFEIRP PFSQLVLLLE RLLGEGYKKK YQQVDEEFLR
660 670 680 690 700
SDHPAILRSQ ARLPGFHGLR SPLDTSSVLY TAVQPNEGDN DYIIPLPDPK
710 720 730 740 750
PEVADEGPLE GSPSLASSTL NEVNTSSTIS CDSPLEPQDE PEPEPQLELQ
760 770
VEPEPELEQL PDSGCPAPRA EAEDSFL
Length:777
Mass (Da):86,905
Last modified:April 26, 2005 - v1
Checksum:iD9865277C3839F9C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209657 mRNA. Translation: BAD92894.1.
RefSeqiNP_002600.1. NM_002609.3.
UniGeneiHs.509067.

Genome annotation databases

GeneIDi5159.
KEGGihsa:5159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209657 mRNA. Translation: BAD92894.1.
RefSeqiNP_002600.1. NM_002609.3.
UniGeneiHs.509067.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000261799.

Proteomic databases

PaxDbiQ59F04.
PeptideAtlasiQ59F04.
PRIDEiQ59F04.

Protocols and materials databases

DNASUi5159.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5159.
KEGGihsa:5159.

Organism-specific databases

CTDi5159.
PharmGKBiPA33148.

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
HOVERGENiHBG004335.
KOiK05089.

Miscellaneous databases

GenomeRNAii5159.

Gene expression databases

GenevisibleiQ59F04. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR027288. PGFRB.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PANTHERiPTHR24416:SF53. PTHR24416:SF53. 2 hits.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: SpleenImported.

Entry informationi

Entry nameiQ59F04_HUMAN
AccessioniPrimary (citable) accession number: Q59F04
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 6, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.