Q59F04 (Q59F04_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Platelet-derived growth factor receptor beta variant EMBL BAD92894.1
Organism	Homo sapiens (Human) EMBL BAD92894.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	777 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SAAS SAAS020635
Sequence similarities	Contains 1 protein kinase domain. SAAS SAAS020635

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS020635
Ligand	ATP-binding RuleBase RU000304 SAAS SAAS020635 Nucleotide-binding
Molecular function	Kinase Receptor SAAS SAAS020635 EMBL BAD92894.1 Transferase Tyrosine-protein kinase SAAS SAAS020635
PTM	Phosphoprotein RuleBase RU003595 SAAS SAAS020635
Gene Ontology (GO)
Biological process	transmembrane receptor protein tyrosine kinase signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW transmembrane receptor protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92894.1

Sequences

	Sequence		Length	Mass (Da)
	Q59F04 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: D9865277C3839F9C	FASTA	777	86,905
	10 20 30 40 50 60 AASEPDTAGS VRGLPTAHCP VVQDNRTLGD SSAGEIALST RNVSETRYVS ELTLVRVKVA 70 80 90 100 110 120 EAGHYTMRAF HEDAEVQLSF QLQINVPVRV LELSESHPDS GEQTVRCRGR GMPQPNIIWS 130 140 150 160 170 180 ACRDLKRCPR ELPPTLLGNS SEEESQLETN VTYWEEEQEF EVVSTLRLQH VDRPLSVRCT 190 200 210 220 230 240 LRNAVGQDTQ EVIVVPHSLP FKVVVISAIL ALVVLTIISL IILIMLWQKK PRYEIRWKVI 250 260 270 280 290 300 ESVSSDGHEY IYVDPMQLPY DSTWELPRDQ LVLGRTLGSG AFGQVVEATA HGLSHSQATM 310 320 330 340 350 360 KVAVKMLKST ARSSEKQALM SELKIMSHLG PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL 370 380 390 400 410 420 VDYLHRNKHT FLQHHSDKRR PPSAELYSNA LPVGLPLPSH VSLTGESDGG YMDMSKDESV 430 440 450 460 470 480 DYVPMLDMKG DVKYADIESS NYMAPYDNYV PSAPERTCRA TLINESPVLS YMDLVGFSYQ 490 500 510 520 530 540 VANGMEFLAS KNCVHRDLAA RNVLICEGKL VKICDFGLAR DIMRDSNYIS KGSTFLPLKW 550 560 570 580 590 600 MAPESIFNSL YTTLSDVWSF GILLWEIFTL GGTPYPELPM NEQFYNAIKR GYRMAQPAHA 610 620 630 640 650 660 SDEIYEIMQK CWEEKFEIRP PFSQLVLLLE RLLGEGYKKK YQQVDEEFLR SDHPAILRSQ 670 680 690 700 710 720 ARLPGFHGLR SPLDTSSVLY TAVQPNEGDN DYIIPLPDPK PEVADEGPLE GSPSLASSTL 730 740 750 760 770 NEVNTSSTIS CDSPLEPQDE PEPEPQLELQ VEPEPELEQL PDSGCPAPRA EAEDSFL

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Spleen EMBL BAD92894.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209657 mRNA. Translation: BAD92894.1.
IPI	IPI01010238.
RefSeq	NP_002600.1. NM_002609.3.
UniGene	Hs.509067.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q59F04.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5159.
KEGG	hsa:5159.
Organism-specific databases
CTD	5159.
Phylogenomic databases
GeneTree	ENSGT00600000084056.
HOVERGEN	HBG004335.
Gene expression databases
ArrayExpress	Q59F04.
Bgee	Q59F04.
Family and domain databases
InterPro	IPR013783. Ig-like_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR001824. Tyr_kinase_rcpt_3_CS. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K05089.
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00240. RECEPTOR_TYR_KIN_III. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	19958.

Entry information

Entry name

Q59F04_HUMAN

Accession

Primary (citable) accession number: Q59F04

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	November 16, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.