Unreviewed, UniProtKB/TrEMBL Q59EZ2 (Q59EZ2_HUMAN)

Names and origin

Protein names	Submitted name:     Telomerase protein component 1 variant EMBL BAD92906.1
Organism	Homo sapiens (Human) EMBL BAD92906.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1903 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 NACHT domain. Spearmint SPM007111

Ontologies

Keywords
Domain	Repeat RuleBase RU003532V3 WD repeat RuleBase RU000362V4
Ligand	ATP-binding Spearmint SPM007111 Nucleotide-binding
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	ribonucleoprotein complex Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92906.1

Sequences

	Sequence		Length	Mass (Da)
	Q59EZ2-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: AA48E60B3243DEEB	FASTA	1,903	207,787
	10 20 30 40 50 60 MLNRYRQALE TAVNLSVKHS LPLLPGRTVL VYLTDANADR LCPKSNPQGP PLNYALLLIG 70 80 90 100 110 120 MMITRAEQVD VVLCGGDTLK TAVLKAEEGI LKTAIKLQAQ VQEFDENDGW SLNTFGKYLL 130 140 150 160 170 180 SLAGQRVPVD RVILLGQSMD DGMINVAKQL YWQRVNSKCL FVGILLRRVQ YLSTDLNPND 190 200 210 220 230 240 VTLSGCTDAI LKFIAEHGAS HLLEHVGQMD KIFKIPPPPG KTGVQSLRPL EEDTPSPLAP 250 260 270 280 290 300 VSQQGWRSIR LFISSTFRDM HGERDLLRSV LPALQARAAP HRISLHGIDL RWGVTEEETR 310 320 330 340 350 360 RNRQLEVCLG EVENAQLFVG ILGSRYGYIP PSYNLPDHPH FHWAQQYPSG RSVTEMEVMQ 370 380 390 400 410 420 FLNRNQRLQP SAQALIYFRD SSFLSSVPDA WKSDFVSESE EAACRISELK SYLSRQKGIT 430 440 450 460 470 480 CRRYPCEWGG VAAGRPYVGG LEEFGQLVLQ DVWNMIQKLY LQPGALLEQP VSIPDDDLVQ 490 500 510 520 530 540 ATFQQLQKPP SPARPRLLQD TVQQLMLPHG RLSLVTGQSG QGKTAFLASL VSALQAPDGA 550 560 570 580 590 600 KVAPLVFFHF SGARPDQGLA LTLLRRLCTY LRGQLKEPGA LPSTYRSLVW ELQQRLLPKS 610 620 630 640 650 660 AESLHPGQTQ VLIIDGADRL VDQNGQLISD WIPKKLPRCV HLVLSVSSDA GLGETLEQSQ 670 680 690 700 710 720 GAHVLALGPL EASARARLVR EELALYGKRL EESPFNNQRE SGRPLYLRLV TDHLRLFTLY 730 740 750 760 770 780 EQVSERLRTL PATVPLLLQH ILSTLEKEHG PDVLPQALTA LEVTRSGLTV DQLHGVLSVW 790 800 810 820 830 840 RTLPKGTKSW EEAVAAGNSG DPYPMGPFAY LVQSLRSLLG EGPLERPGAR LCLPDGPLRT 850 860 870 880 890 900 AAKRCYGKRP GLEDTAHILI AAQLWKTCDA DASGTFRSCP PEALGDLPYH LLQSGNRGLL 910 920 930 940 950 960 SKFLTNLHVV AAHLELGLVS RLLEAHALYA SSVPKEEQKL PEADVAVFRT FLRQQASILS 970 980 990 1000 1010 1020 QYPRLLPQQA ANQPLDSPLC HQASLLSRRW HLQHTLRWLN KPRTMKNQQS SSLSLAVSSS 1030 1040 1050 1060 1070 1080 PTAVAFSTNG QRAAVGTANG TVYLLDLRTW QEEKSVVSGC DGISACLFLS DDTLFLTAFD 1090 1100 1110 1120 1130 1140 GLLELWDLQH GCRVLQTKAH QYQITGCCLS PDCQLLATVC LGGCLKLWDT VRGQLAFQHT 1150 1160 1170 1180 1190 1200 YPKSLNCVAF HPEGQVIATG SWAGSISFFQ VDGLKVTKDL GAPGASIRTL AFNVPGGVVA 1210 1220 1230 1240 1250 1260 VGRLDSMVEL WAWREGARLA AFPAHHGFVA AALFLHAGCQ LLTAGEDGKV QVWSGSLGRP 1270 1280 1290 1300 1310 1320 RGHLGSLSLS PALSVALSPD GDRVAVGYRA DGIRIYKISS GSQGAQGQAL DVAVSALAWL 1330 1340 1350 1360 1370 1380 SPKVLVSGAE DGSLQGWALK ECSLQSLWLL SRFQKPVLGL ATSQELLASA SEDFTVQLWP 1390 1400 1410 1420 1430 1440 RQLLTRPHKA EDFPCGTELR GHEGPVSCCS FSTDGGSLAT GGRDRSLLCW DVRTPKTPVL 1450 1460 1470 1480 1490 1500 IHSFPACHRD WVTGCAWTKD NLLISCSSDG SVGLWDPESG QRLGQFLGHQ SAVSAVAAVE 1510 1520 1530 1540 1550 1560 EHVVSVSRDG TLKVWDHQGV ELTSIPAHSG PISHCAAAME PRAAGQPGSE LLVVTVGLDG 1570 1580 1590 1600 1610 1620 ATRLWHPLLV CQTHTLLGHS GPVRAAAVSE TSGLMLTASE DGSVRLWQVP KEADDTCIPR 1630 1640 1650 1660 1670 1680 SSAAVTAVAW APDGSMAVSG NQAGELILWQ EAKAVATAQA PGHIGALIWS SAHTFFVLSA 1690 1700 1710 1720 1730 1740 DEKISEWQVK LRKGSAPGNL SLHLNRILQE DLGVLTSLDW APDGHFLILA KADLKLLCMK 1750 1760 1770 1780 1790 1800 PGDAPSEIWS SYTENPMILS THKEYGIFVL QPKDPGVLSF LRQKESGEFE ERLNFDINLE 1810 1820 1830 1840 1850 1860 NPSRTLISIT QAKPESESSF LCASSDGILW NLAKCSPEGE WTTGNMWQKK ANTPETQTPG 1870 1880 1890 1900 TDPSTCRESD ASMDSDASMD SEPTPHLKTR QRRKPSMCYL SCW

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92906.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB209669 mRNA. Translation: BAD92906.1.
UniGene	Hs.508835
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000129566. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:11726. TEP1.
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q59EZ2.
Gene expression databases
ArrayExpress	Q59EZ2.
Family and domain databases
InterPro	IPR007111. NACHT_NTPase. IPR008858. TROVE. IPR015943. WD40/YVTN_repeat-like. IPR001680. WD40_repeat. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 3 hits.
Pfam	PF05729. NACHT. 1 hit. PF05731. TROVE. 1 hit. PF00400. WD40. 9 hits. [Graphical view]
PRINTS	PR00320. GPROTEINBRPT.
ProDom	PD000018. WD40. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00320. WD40. 17 hits. [Graphical view]
PROSITE	PS50837. NACHT. 1 hit. PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 6 hits. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]

Entry information

Entry name

Q59EZ2_HUMAN

Accession

Primary (citable) accession number: Q59EZ2

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	November 25, 2008
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)