Q59EX8 (Q59EX8_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Low density lipoprotein receptor-related protein 6 variant EMBL BAD92920.1
Organism	Homo sapiens (Human) EMBL BAD92920.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1477 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Cellular component	Membrane
Domain	EGF-like domain SAAS SAAS000033 Repeat SAAS SAAS000033 Transmembrane Transmembrane helix SAAS SAAS000033
Molecular function	Receptor EMBL BAD92920.1
PTM	Disulfide bond SAAS SAAS000033 Lipoprotein EMBL BAD92920.1
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92920.1

Sequences

	Sequence		Length	Mass (Da)
	Q59EX8 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: B557BA6A898BA30F	FASTA	1,477	165,394
	10 20 30 40 50 60 LDQPRAIALD PSSGFMYWTD WGEVPKIERA GMDGSSRFII INSEIYWPNG LTLDYEEQKL 70 80 90 100 110 120 YWADAKLNFI HKSNLDGTNR QAVVKGSLPH PFALTLFEDI LYWTDWSTHS ILACNKYTGE 130 140 150 160 170 180 GLREIHSDIF SPMDIHAFSQ QRQPNATNPC GIDNGGCSHL CLMSPVKPFY QCACPTGVKL 190 200 210 220 230 240 LENGKTCKDG ATELLLLARR TDLRRISLDT PDFTDIVLQL EDIRHAIAID YDPVEGYIYW 250 260 270 280 290 300 TDDEVRAIRR SFIDGSGSQF VVTAQIAHPD GIAVDWVARN LYWTDTGTDR IEVTRLNGTM 310 320 330 340 350 360 RKILISEDLE EPRAIVLDPM VGYMYWTDWG EIPKIERAAL DGSDRVVLVN TSLGWPNGLA 370 380 390 400 410 420 LDYDEGKIYW GDAKTDKIEV MNTDGTGRRV LVEDKIPHIF GFTLLGDYVY WTDWQRRSIE 430 440 450 460 470 480 RVHKRSAERE VIIDQLPDLM GLKATNVHRV IGSNPCAEEN GGCSHLCLYR PQGLRCACPI 490 500 510 520 530 540 GFELISDMKT CIVPEAFLLF SRRADIRRIS LETNNNNVAI PLTGVKEASA LDFDVTDNRI 550 560 570 580 590 600 YWTDISLKTI SRAFMNGSAL EHVVEFGLDY PEGMAVDWLG KNLYWADTGT NRIEVSKLDG 610 620 630 640 650 660 QHRQVLVWKD LDSPRALALD PAEGFMYWTE WGGKPKIDRA AMDGSERTTL VPNVGRANGL 670 680 690 700 710 720 TIDYAKRRLY WTDLDTNLIE SSNMLGLNRE VIADDLPHPF GLTQYQDYIY WTDWSRRSIE 730 740 750 760 770 780 RANKTSGQNR TIIQGHLDYV MDILVFHSSR QSGWNECASS NGHCSHLCLA VPVGGFVCGC 790 800 810 820 830 840 PAHYSLNADN RTCSAPTTFL LFSQKSAINR MVIDEQQSPD IILPIHSLRN VRAIDYDPLD 850 860 870 880 890 900 KQLYWIDSRQ NMIRKAQEDG SQGFTVVVSS VPSQNLEIQP YDLSIDIYSR YIYWTCEATN 910 920 930 940 950 960 VINVTRLDGR SVGVVLKGEQ DRPRAIVVNP EKGYMYFTNL QERSPKIERA ALDGTEREVL 970 980 990 1000 1010 1020 FFSGLSKPIA LALDSRLGKL FWADSDLRRI ESSDLSGANR IVLEDSNILQ PVGLTVFENW 1030 1040 1050 1060 1070 1080 LYWIDKQQQM IEKIDMTGRE GRTKVQARIA QLSDIHAVKE LNLQEYRQHP CAQDNGGCSH 1090 1100 1110 1120 1130 1140 ICLVKGDGTT RCSCPMHLVL LQDELSCGEP PTCSPQQFTC FTGEIDCIPV AWRCDGFTEC 1150 1160 1170 1180 1190 1200 EDHSDELNCP VCSESQFQCA SGQCIDGALR CNGDANCQDK SDEKNCEVLC LIDQFRCANG 1210 1220 1230 1240 1250 1260 QCIGKHKKCD HNVDCSDKSD ELDCYPTEEP APQATNTVGS VIGVIVTIFV SGTVYFICQR 1270 1280 1290 1300 1310 1320 MLCPRMKGDG ETMTNDYVVH GPASVPLGYV PHPSSLSGSL PGMSRGKSMI SSLSIMGGSS 1330 1340 1350 1360 1370 1380 GPPYDRAHVT GASSSSSSST KGTYFPAILN PPPSPATERS HYTMEFGYSS NSPSTHRSYS 1390 1400 1410 1420 1430 1440 YRPYSYRHFA PPTTPCSTDV CDSDYAPSRR MTSVATAKGY TSDLNYDSEP VPPPPTPRSQ 1450 1460 1470 YLSAEENYES CPPSPYTERS YSHHLYPPPP SPCTDSS

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL BAD92920.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209683 mRNA. Translation: BAD92920.1.
IPI	IPI01010047.
UniGene	Hs.584775. Hs.658913.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG049167.
Family and domain databases
Gene3D	2.120.10.30. 4 hits. 4.10.400.10. 3 hits.
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR000742. EG-like_dom. IPR023415. LDLR_class-A_CS. IPR000033. LDLR_classB_rpt. IPR002172. LDrepeatLR_classA_rpt. [Graphical view]
Pfam	PF00057. Ldl_recept_a. 3 hits. PF00058. Ldl_recept_b. 12 hits. [Graphical view]
SMART	SM00181. EGF. 4 hits. SM00192. LDLa. 3 hits. SM00135. LY. 18 hits. [Graphical view]
SUPFAM	SSF57424. LDL_rcpt_classA_cys-rich. 3 hits.
PROSITE	PS01209. LDLRA_1. 3 hits. PS50068. LDLRA_2. 3 hits. PS51120. LDLRB. 18 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59EX8_HUMAN

Accession

Primary (citable) accession number: Q59EX8

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	April 3, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.