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Protein
Submitted name:

N-methyl-D-aspartate receptor subunit 2A variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotationImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
N-methyl-D-aspartate receptor subunit 2A variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei584 – 60623HelicalSequence analysisAdd
BLAST
Transmembranei656 – 67823HelicalSequence analysisAdd
BLAST
Transmembranei847 – 87024HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28979.

PTM / Processingi

Proteomic databases

PaxDbiQ59EW6.
PeptideAtlasiQ59EW6.
PRIDEiQ59EW6.

Expressioni

Gene expression databases

GenevisibleiQ59EW6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332549.

Structurei

3D structure databases

ProteinModelPortaliQ59EW6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini458 – 825368PBPeInterPro annotationAdd
BLAST
Domaini466 – 52964Lig_chan-Glu_bdInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
HOGENOMiHOG000113802.
HOVERGENiHBG052635.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PF10565. NMDAR2_C. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59EW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GGRDARARSA PHCILDLLGL QGPSVATMGR VGYWTLLVLP ALLVWRGPAP
60 70 80 90 100
SAAAEKGPPA LNIAVMLGHS HDVTERELRT LWGPEQAAGL PLDVNVVALL
110 120 130 140 150
MNRTDPKSLI THVCDLMSGA RIHGLVFGDD TDQEAVAQML DFISSHTFVP
160 170 180 190 200
ILGIHGGASM IMADKDPTST FFQFGASIQQ QATVMLKIMQ DYDWHVFSLV
210 220 230 240 250
TTIFPGYREF ISFVKTTVDN SFVGWDMQNV ITLDTSFEDA KTQVQLKKIH
260 270 280 290 300
SSVILLYCSK DEAVLILSEA RSLGLTGYDF FWIVPSLVSG NTELIPKEFP
310 320 330 340 350
SGLISVSYDD WDYSLEARVR DGIGILTTAA SSMLEKFSYI PEAKASCYGQ
360 370 380 390 400
MERPEVPMHT LHPFMVNVTW DGKDLSFTEE GYQVHPRLVV IVLNKDREWE
410 420 430 440 450
KVGKWENHTL SLRHAVWPRY KSFSDCEPDD NHLSIVTLEE APFVIVEDID
460 470 480 490 500
PLTETCVRNT VPCRKFVKIN NSTNEGMNVK KCCKGFCIDI LKKLSRTVKF
510 520 530 540 550
TYDLYLVTNG KHGKKVNNVW NGMIGEVVYQ RAVMAVGSLT INEERSEVVD
560 570 580 590 600
FSVPFVETGI SVMVSRSNGT VSPSAFLEPF SASVWVMMFV MLLIVSAIAV
610 620 630 640 650
FVFEYFSPVG YNRNLAKGKA PHGPSFTIGK AIWLLWGLVF NNSVPVQNPK
660 670 680 690 700
GTTSKIMVSV WAFFAVIFLA SYTANLAAFM IQEEFVDQVT GLSDKKFQRP
710 720 730 740 750
HDYSPPFRFG TVPNGSTERN IRNNYPYMHQ YMTKFNQKGV EDALVSLKTG
760 770 780 790 800
KLDAFIYDAA VLNYKAGRDE GCKLVTIGSG YIFATTGYGI ALQKGSPWKR
810 820 830 840 850
QIDLALLQFV GDGEMEELET LWLTGICHNE KNEVMSSQLD IDNMAGVFYM
860 870 880 890 900
LAAAMALSLI TFIWEHLFYW KLRFCFTGVC SDRPGLLFSI SRGIYSCIHG
910 920 930 940 950
VHIEEKKKSP DFNLTGSQSN MLKLLRSAKN ISSMSNMNSS RMDSPKRAAD
960 970 980 990 1000
FIQRGSLIMD MVSDKGNLMY SDNRSFQGKE SIFGDNMNEL QTFVANRQKD
1010 1020 1030 1040 1050
NLNNYVFQGQ HPLTLNESNP NTVEVAVSTE SKANSRPRQL WKKSVDSIRQ
1060 1070 1080 1090 1100
DSLSQNPVSQ RDEATAENRT HSLKSPRYLP EEMAHSDFSE TSNRATCHRE
1110 1120 1130 1140 1150
PDNSKNHKTK DNFKRSVASK YPKDCSEVER TYLKTKSSSP RDKIYTIDGE
1160 1170 1180 1190 1200
KEPGFHLDPP QFVENVTLPE NVDFPDPYQD PSENFRKGDS TLPMNRNPLH
1210 1220 1230 1240 1250
NEEGLSNNDQ YKLYSKHFTL KDKGSPHSET SERYRQNSTH CRSCLSNMPT
1260 1270 1280 1290 1300
YSGHFTMRSP FKCDACLRMG NLYDIDEDQM LQETGNPATG EQVYQQDWAQ
1310 1320 1330 1340 1350
NNALQLQKNK LRISRQHSYD NIVDKPRELD LSRPSRSISL KDRERLLEGN
1360 1370 1380 1390 1400
FYGSLFSVPS SKLSGKKSSL FPQGLEDSKR SKSLLPDHTS DNPFLHSHRD
1410 1420 1430 1440 1450
DQRLVIGRCP SDPYKHSLPS QAVNDSYLRS SLRSTASYCS RDSRGHNDVY
1460 1470 1480 1490
ISEHVMPYAA NKNNMYSTPR VLNSCSNRRV YKKMPSIESD V
Length:1,491
Mass (Da):168,031
Last modified:April 26, 2005 - v1
Checksum:i05F8E12D0AA8A0D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209695 mRNA. Translation: BAD92932.1.
RefSeqiNP_001127879.1. NM_001134407.2.
UniGeneiHs.411472.

Genome annotation databases

GeneIDi2903.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209695 mRNA. Translation: BAD92932.1.
RefSeqiNP_001127879.1. NM_001134407.2.
UniGeneiHs.411472.

3D structure databases

ProteinModelPortaliQ59EW6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332549.

Proteomic databases

PaxDbiQ59EW6.
PeptideAtlasiQ59EW6.
PRIDEiQ59EW6.

Protocols and materials databases

DNASUi2903.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2903.

Organism-specific databases

CTDi2903.
PharmGKBiPA28979.

Phylogenomic databases

eggNOGiKOG1053. Eukaryota.
ENOG410XNUR. LUCA.
HOGENOMiHOG000113802.
HOVERGENiHBG052635.

Miscellaneous databases

GenomeRNAii2903.

Gene expression databases

GenevisibleiQ59EW6. HS.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR019594. Glu/Gly-bd.
IPR001508. Iono_rcpt_met.
IPR001320. Iontro_rcpt.
IPR018884. NMDAR2_C.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00060. Lig_chan. 1 hit.
PF10613. Lig_chan-Glu_bd. 1 hit.
PF10565. NMDAR2_C. 1 hit.
[Graphical view]
PRINTSiPR00177. NMDARECEPTOR.
SMARTiSM00918. Lig_chan-Glu_bd. 1 hit.
SM00079. PBPe. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59EW6_HUMAN
AccessioniPrimary (citable) accession number: Q59EW6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.