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Protein
Submitted name:

F-box protein FBW7 isoform 2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ59ET6.

Names & Taxonomyi

Protein namesi
Submitted name:
F-box protein FBW7 isoform 2 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ59ET6.

Expressioni

Gene expression databases

BgeeiENSG00000109670.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281708.

Structurei

3D structure databases

ProteinModelPortaliQ59ET6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini195 – 241F-boxInterPro annotationAdd BLAST47
Domaini293 – 576WD_REPEATS_REGIONInterPro annotationAdd BLAST284
Repeati308 – 333WDPROSITE-ProRule annotationAdd BLAST26
Repeati334 – 373WDPROSITE-ProRule annotationAdd BLAST40
Repeati374 – 413WDPROSITE-ProRule annotationAdd BLAST40
Repeati414 – 453WDPROSITE-ProRule annotationAdd BLAST40
Repeati454 – 493WDPROSITE-ProRule annotationAdd BLAST40
Repeati494 – 533WDPROSITE-ProRule annotationAdd BLAST40
Repeati537 – 576WDPROSITE-ProRule annotationAdd BLAST40

Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
ENOG410XRWX. LUCA.
HOVERGENiHBG051596.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59ET6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PRSGLILSCI CLYCGVLLPV LLPNLPFLTC LSMSTLESVT YLPEKGLYCQ
60 70 80 90 100
RLPSSRTHGG TESLKGKNTE NMGFYGTLKM IFYKMKRKLD HGSEVRSFSL
110 120 130 140 150
GKKPCKVSEY TSTTGLVPCS ATPTTFGDLR AANGQGQQRR RITSVQPPTG
160 170 180 190 200
LQEWLKMFQS WSGPEKLLAL DELIDSCEPT QVKHMMQVIE PQFQRDFISL
210 220 230 240 250
LPKELALYVL SFLEPKDLLQ AAQTCRYWRI LAEDNLLWRE KCKEEGIDEP
260 270 280 290 300
LHIKRRKVIK PGFIHSPWKS AYIRQHRIDT NWRRGELKSP KVLKGHDDHV
310 320 330 340 350
ITCLQFCGNR IVSGSDDNTL KVWSAVTGKC LRTLVGHTGG VWSSQMRDNI
360 370 380 390 400
IISGSTDRTL KVWNAETGEC IHTLYGHTST VRCMHLHEKR VVSGSRDATL
410 420 430 440 450
RVWDIETGQC LHVLMGHVAA VRCVQYDGRR VVSGAYDFMV KVWDPETETC
460 470 480 490 500
LHTLQGHTNR VYSLQFDGIH VVSGSLDTSI RVWDVETGNC IHTLTGHQSL
510 520 530 540 550
TSGMELKDNI LVSGNADSTV KIWDIKTGQC LQTLQGPNKH QSAVTCLQFN
560 570 580 590 600
KNFVITSSDD GTVKLWDLKT GEFIRNLVTL ESGGSGGVVW RIRASNTKLV
610 620
CAVGSRNGTE ETKLLVLDFD VDMK
Length:624
Mass (Da):69,991
Last modified:April 26, 2005 - v1
Checksum:i2850F0F78C2039E1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209725 mRNA. Translation: BAD92962.1.
UniGeneiHs.561245.
Hs.717081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209725 mRNA. Translation: BAD92962.1.
UniGeneiHs.561245.
Hs.717081.

3D structure databases

ProteinModelPortaliQ59ET6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281708.

Proteomic databases

PaxDbiQ59ET6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0274. Eukaryota.
ENOG410XRWX. LUCA.
HOVERGENiHBG051596.

Enzyme and pathway databases

SignaLinkiQ59ET6.

Gene expression databases

BgeeiENSG00000109670.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59ET6_HUMAN
AccessioniPrimary (citable) accession number: Q59ET6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 15, 2017
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.