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Protein
Submitted name:

F-box protein FBW7 isoform 2 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ59ET6.

Names & Taxonomyi

Protein namesi
Submitted name:
F-box protein FBW7 isoform 2 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: HPA
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ59ET6.
ExpressionAtlasiQ59ET6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ59ET6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 F-box domain.UniRule annotation

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

HOVERGENiHBG051596.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59ET6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PRSGLILSCI CLYCGVLLPV LLPNLPFLTC LSMSTLESVT YLPEKGLYCQ
60 70 80 90 100
RLPSSRTHGG TESLKGKNTE NMGFYGTLKM IFYKMKRKLD HGSEVRSFSL
110 120 130 140 150
GKKPCKVSEY TSTTGLVPCS ATPTTFGDLR AANGQGQQRR RITSVQPPTG
160 170 180 190 200
LQEWLKMFQS WSGPEKLLAL DELIDSCEPT QVKHMMQVIE PQFQRDFISL
210 220 230 240 250
LPKELALYVL SFLEPKDLLQ AAQTCRYWRI LAEDNLLWRE KCKEEGIDEP
260 270 280 290 300
LHIKRRKVIK PGFIHSPWKS AYIRQHRIDT NWRRGELKSP KVLKGHDDHV
310 320 330 340 350
ITCLQFCGNR IVSGSDDNTL KVWSAVTGKC LRTLVGHTGG VWSSQMRDNI
360 370 380 390 400
IISGSTDRTL KVWNAETGEC IHTLYGHTST VRCMHLHEKR VVSGSRDATL
410 420 430 440 450
RVWDIETGQC LHVLMGHVAA VRCVQYDGRR VVSGAYDFMV KVWDPETETC
460 470 480 490 500
LHTLQGHTNR VYSLQFDGIH VVSGSLDTSI RVWDVETGNC IHTLTGHQSL
510 520 530 540 550
TSGMELKDNI LVSGNADSTV KIWDIKTGQC LQTLQGPNKH QSAVTCLQFN
560 570 580 590 600
KNFVITSSDD GTVKLWDLKT GEFIRNLVTL ESGGSGGVVW RIRASNTKLV
610 620
CAVGSRNGTE ETKLLVLDFD VDMK
Length:624
Mass (Da):69,991
Last modified:April 26, 2005 - v1
Checksum:i2850F0F78C2039E1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209725 mRNA. Translation: BAD92962.1.
UniGeneiHs.561245.
Hs.717081.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209725 mRNA. Translation: BAD92962.1.
UniGeneiHs.561245.
Hs.717081.

3D structure databases

ProteinModelPortaliQ59ET6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG051596.

Enzyme and pathway databases

SignaLinkiQ59ET6.

Gene expression databases

BgeeiQ59ET6.
ExpressionAtlasiQ59ET6. baseline and differential.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR001810. F-box_dom.
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00256. FBOX. 1 hit.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
SSF81383. SSF81383. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
PS00678. WD_REPEATS_1. 5 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59ET6_HUMAN
AccessioniPrimary (citable) accession number: Q59ET6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: February 4, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.