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Protein
Submitted name:

Inositol 1,4,5-trisphosphate receptor type 3 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation, ReceptorImported

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Inositol 1,4,5-trisphosphate receptor type 3 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1871 – 189626HelicalSequence analysisAdd
BLAST
Transmembranei1908 – 192619HelicalSequence analysisAdd
BLAST
Transmembranei1938 – 195821HelicalSequence analysisAdd
BLAST
Transmembranei1994 – 201926HelicalSequence analysisAdd
BLAST
Transmembranei2039 – 206123HelicalSequence analysisAdd
BLAST
Transmembranei2168 – 219124HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29980.

PTM / Processingi

Proteomic databases

PaxDbiQ59ES2.
PRIDEiQ59ES2.

Expressioni

Gene expression databases

GenevisibleiQ59ES2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363435.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 10188MIRInterPro annotationAdd
BLAST
Domaini144 – 340197RYDR_ITPRInterPro annotationAdd
BLAST
Domaini857 – 996140RYDR_ITPRInterPro annotationAdd
BLAST
Domaini1537 – 1643107RIH_assocInterPro annotationAdd
BLAST
Domaini1910 – 2197288Ion_transInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili2299 – 232628Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
HOVERGENiHBG052158.
KOiK04960.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF82109. SSF82109. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59ES2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KAAGMGAQGR TGRRNAGEKI KYCLVAVPHG NDIASLFELD PTTLQKTDSF
60 70 80 90 100
VPRNSYVRLR HLCTNTWIQS TNVPIDIEEE RPIRLMLGTC PTKEDKEAFA
110 120 130 140 150
IVSVPVSEIR DLDFANDASS MLASAVEKLN EGFISQNDRR FVIQLLEDLV
160 170 180 190 200
FFVSDVPNNG QNVLDIMVTK PNRERQKLMR EQNILKQVFG ILKAPFREKG
210 220 230 240 250
GEGPLVRLEE LSDQKNAPYQ HMFRLCYRVL RHSQEDYRKN QEHIAKQFGM
260 270 280 290 300
MQSQIGYDIL AEDTITALLH NNRKLLEKHI TKTEVETFVS LVRKNREPRF
310 320 330 340 350
LDYLSDLCVS NHIAIPVTQE LICKCVLDPK NSDILIRTEL RPVKEMAQSH
360 370 380 390 400
EYLSIEYSEE EVWLTWTDKN NEHHEKSVRQ LAQEARAGNA HDENVLSYYR
410 420 430 440 450
YQLKLFARMC LDRQYLAIDE ISQQLGVDLI FLCMADEMLP FDLRASFCHL
460 470 480 490 500
MLHVHVDRDP QELVTPVKFA RLWTEIPTAI TIKDYDSNLN ASRDDKKNKF
510 520 530 540 550
ANTMEFVEDY LNNVVSEAVP FANEEKNKLT FEVVSLAHNL IYFGFYSFSE
560 570 580 590 600
LLRLTRTLLG IIDCVQGPPA MLQAYEDPGG KNVRRSIQGV GHMMSTMVLS
610 620 630 640 650
RKQSVFSAPS LSAGASAAEP LDRSKFEENE DIVVMETKLK ILEILQFILN
660 670 680 690 700
VRLDYRISYL LSVFKKEFVE VFPMQDSGAD GTASAFDSTT ANMNLDRIGE
710 720 730 740 750
QAEAMFGVGK TSSMLEVDDE GGRMFLRVLI HLTMHDYAPL VSGALQLLFK
760 770 780 790 800
HFSQRQEAMH TFKQVQLLIS AQDVENYKVI KSELDRLRTM VEKSELWVDK
810 820 830 840 850
KGSGKGEEVE AGAAKDKKER PTDEEGFLHP PGEKSSENYQ IVKGILERLN
860 870 880 890 900
KMCGVGEQMR KKQQRLLKNM DAHKVMLDLL QIPYDKGDAK MMEILRYTHQ
910 920 930 940 950
FLQKFCAGNP GNQALLHKHL HLFLTPGLLE AETMQHIFLN NYQLCSEISE
960 970 980 990 1000
PVLQHFVHLL ATHGRHVQYL DFLHTVIKAE GKYVKKCQDM IMTELTNAGD
1010 1020 1030 1040 1050
DVVVFYNDKA SLAHLLDMMK AARDGVEDHS PLMYHISLVD LLAACAEGKN
1060 1070 1080 1090 1100
VYTEIKCTSL LPLEDVVSVV THEDCITEVK MAYVNFVNHC YVDTEVEMKE
1110 1120 1130 1140 1150
IYTSNHIWTL FENFTLDMAR VCSKREKRVA DPTLEKYVLS VVLDTINAFF
1160 1170 1180 1190 1200
SSPFSENSTS LQTHQTIVVQ LLQSTTRLLE CPWLQQQHKG SVEACIRTLA
1210 1220 1230 1240 1250
MVAKGRAILL PMDLDAHISS MLSSGASCAA AAQRNASSYK ATTRAFPRVT
1260 1270 1280 1290 1300
PTANQWDYKN IIEKLQDIIT ALEERLKPLV QAELSVLVDV LHWPELLFLE
1310 1320 1330 1340 1350
GSEAYQRCES GGFLSKLIQH TKDLMESEEK LCIKVLRTLQ QMLLKKTKYG
1360 1370 1380 1390 1400
DRGNQLRKML LQNYLQNRKS TSRGDLPDPI GTGLDPDWSA IAATQCRLDK
1410 1420 1430 1440 1450
EGATKLVCDL ITSTKNEKIF QESIGLAIHL LDGGNTEIQK SFHNLMMSDK
1460 1470 1480 1490 1500
KSERFFKVLH DRMKRAQQET KSTVAVNMND LGSQPHEDRE PVDPTTKGRV
1510 1520 1530 1540 1550
ASFSIPGSSS RYSLGPSLRR GHEVSERVQS SEMGTSVLIM QPILRFLQLL
1560 1570 1580 1590 1600
CENHNRDLQN FLRCQNNKTN YNLVCETLQF LDIMCGSTTG GLGLLGLYIN
1610 1620 1630 1640 1650
EDNVGLVIQT LETLTEYCQG PCHENQTCIV THESNGIDII TALILNDISP
1660 1670 1680 1690 1700
LCKYRMDLVL QLKDNASKLL LALMESRHDS ENAERILISL RPQELVDVIK
1710 1720 1730 1740 1750
KAYLQEEERE NSEVSPREVG HNIYILALQL SRHNKQLQHL LKPVKRIQEE
1760 1770 1780 1790 1800
EAEGISSMLS LNNKQLSQML KSSAPAQEEE EDPLAYYENH TSQIEIVRQD
1810 1820 1830 1840 1850
RSMEQIVFPV PGICQFLTEE TKHRLFTTTE QDEQGSKVSD FFDQSSFLHN
1860 1870 1880 1890 1900
EMEWQRKLRS MPLIYWFSRR MTLWGSISFN LAVFINIIIA FFYPYMEGAS
1910 1920 1930 1940 1950
TGVLDSPLIS LLFWILICFS IAALFTKRYS IRPLIVALIL RSIYYLGIGP
1960 1970 1980 1990 2000
TLNILGALNL TNKIVFVVSF VGNRGTFIRG YKAMVMDMEF LYHVGYILTS
2010 2020 2030 2040 2050
VLGLFAHELF YSILLFDLIY REETLFNVIK SVTRNGRSIL LTALLALILV
2060 2070 2080 2090 2100
YLFSIVGFLF LKDDFILEVD RLPNNHSTAS PLGMPHGAAA FVDTCSGDKM
2110 2120 2130 2140 2150
DCVSGLSVPE VLEEDRELDS TERACDTLLM CIVTVMNHGL RNGGGVGDIL
2160 2170 2180 2190 2200
RKPSKDESLF PARVVYDLLF FFIVIIIVLN LIFGVIIDTF ADLRSEKQKK
2210 2220 2230 2240 2250
EEILKTTCFI CGLERDKFDN KTVSFEEHIK LEHNMWNYLY FIVLVRVKNK
2260 2270 2280 2290 2300
TDYTGPESYV AQMIKNKNLD WFPRMRAMSL VSNEGEGEQN EIRILQDKLN
2310 2320 2330 2340
STMKLVSHLT AQLNELKEQM TEQRKRRQRL GFVDVQNCIS R
Length:2,341
Mass (Da):267,023
Last modified:April 26, 2005 - v1
Checksum:i21E4BF7271409D83
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209739 mRNA. Translation: BAD92976.1.
RefSeqiNP_002215.2. NM_002224.3.
UniGeneiHs.65758.

Genome annotation databases

GeneIDi3710.
KEGGihsa:3710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209739 mRNA. Translation: BAD92976.1.
RefSeqiNP_002215.2. NM_002224.3.
UniGeneiHs.65758.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363435.

Proteomic databases

PaxDbiQ59ES2.
PRIDEiQ59ES2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3710.
KEGGihsa:3710.

Organism-specific databases

CTDi3710.
PharmGKBiPA29980.

Phylogenomic databases

eggNOGiKOG3533. Eukaryota.
ENOG410XR97. LUCA.
HOVERGENiHBG052158.
KOiK04960.

Miscellaneous databases

GenomeRNAii3710.
NextBioi14543.

Gene expression databases

GenevisibleiQ59ES2. HS.

Family and domain databases

Gene3Di1.25.10.30. 2 hits.
InterProiIPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR015925. Ryanodine_recept-rel.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 2 hits.
PfamiPF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 2 hits.
SSF82109. SSF82109. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Aorta endothelial cellImported.

Entry informationi

Entry nameiQ59ES2_HUMAN
AccessioniPrimary (citable) accession number: Q59ES2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 16, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.