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Protein
Submitted name:

Leucine-rich repeat-containing G protein-coupled receptor 4 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Leucine-rich repeat-containing G protein-coupled receptor 4 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei620 – 64526HelicalSequence analysisAdd
BLAST
Transmembranei657 – 68125HelicalSequence analysisAdd
BLAST
Transmembranei701 – 72222HelicalSequence analysisAdd
BLAST
Transmembranei743 – 76422HelicalSequence analysisAdd
BLAST
Transmembranei784 – 80926HelicalSequence analysisAdd
BLAST
Transmembranei830 – 85324HelicalSequence analysisAdd
BLAST
Transmembranei865 – 88521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28893.

PTM / Processingi

Proteomic databases

PaxDbiQ59ER8.
PRIDEiQ59ER8.

Expressioni

Gene expression databases

BgeeiQ59ER8.
GenevisibleiQ59ER8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368516.

Structurei

3D structure databases

ProteinModelPortaliQ59ER8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini636 – 882247G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000231829.
HOVERGENiHBG031675.
KOiK04309.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00369. LRR_TYP. 15 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS51450. LRR. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59ER8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AAGGAGLPLR VHGAAGRAKL RSAASLRRCG GLLKGPSPRG PPRKRPPLQP
60 70 80 90 100
AGRLPGGGGG HRRAAERAAP RERPAREAAA AMPGPLGLLC FLALGLLGSA
110 120 130 140 150
GPSGAAPPLC AAPCSCDGDR RVDCSGKGLT AVPEGLSAFT QALDISMNNI
160 170 180 190 200
TQLPEDAFKN FPFLEELQLA GNDLSFIHPK ALSGLKELKV LTLQNNQLKT
210 220 230 240 250
VPSEAIRGLS ALQSLRLDAN HITSVPEDSF EGLVQLRHLW LDDNSLTEVP
260 270 280 290 300
VHPLSNLPTL QALTLALNKI SSIPDFAFTN LSSLVVLHLH NNKIRSLSQH
310 320 330 340 350
CFDGLDNLET LDLNYNNLGE FPQAIKALPS LKELGFHSNS ISVIPDGAFD
360 370 380 390 400
GNPLLRTIHL YDNPLSFVGN SAFHNLSDLH SLVIRGASMV QQFPNLTGTV
410 420 430 440 450
HLESLTLTGT KISSIPNNLC QEQKMLRTLD LSYNNIRDLP SFNGCHALEE
460 470 480 490 500
ISLQRNQIYQ IKEGTFQGLI SLRILDLSRN LIHEIHSRAF ATLGPITNLD
510 520 530 540 550
VSFNELTSFP TEGLNGLNQL KLVGNFKLKE ALAAKDFVNL RSLSVPYAYQ
560 570 580 590 600
CCAFWGCDSY ANLNTEDNSL QDHSVAQEKG TADAANVTST LENEEHSQII
610 620 630 640 650
IHCTPSTGAF KPCEYLLGSW MIRLTVWFIF LVALFFNLLV ILTTFASCTS
660 670 680 690 700
LPSSKLFIGL ISVSNLFMGI YTGILTFLDA VSWGRFAEFG IWWETGSGCK
710 720 730 740 750
VAGFLAVFSS ESAIFLLMLA TVERSLSAKD IMKNGKSNHL KQFRVAALLA
760 770 780 790 800
FLGATVAGCF PLFHRGEYSA SPLCLPFPTG ETPSLGFTVT LVLLNSLAFL
810 820 830 840 850
LMAVIYTKLY CNLEKEDLSE NSQSSMIKHV AWLIFTNCIF FCPVAFFSFA
860 870 880 890 900
PLITAISISP EIMKSVTLIF FPLPACLNPV LYVFFNPKFK EDWKLLKRRV
910 920 930 940 950
TKKSGSVSVS ISSQGGCLEQ DFYYDCGMYS HLQGNLTVCD CCESFLLTKP
960 970 980 990 1000
VSCKHLIKSH SCPALAVASC QRPEGYWSDC GTQSAHSDYA DEEDSFVSDS
1010 1020 1030
SDQVQACGRA CFYQSRGFPL VRYAYNLPRV KD
Length:1,032
Mass (Da):112,564
Last modified:April 26, 2005 - v1
Checksum:iCE35C9546AF1C8FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209743 mRNA. Translation: BAD92980.1.
RefSeqiNP_060960.2. NM_018490.2.
UniGeneiHs.502176.

Genome annotation databases

GeneIDi55366.
KEGGihsa:55366.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209743 mRNA. Translation: BAD92980.1.
RefSeqiNP_060960.2. NM_018490.2.
UniGeneiHs.502176.

3D structure databases

ProteinModelPortaliQ59ER8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368516.

Proteomic databases

PaxDbiQ59ER8.
PRIDEiQ59ER8.

Protocols and materials databases

DNASUi55366.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi55366.
KEGGihsa:55366.

Organism-specific databases

CTDi55366.
PharmGKBiPA28893.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000231829.
HOVERGENiHBG031675.
KOiK04309.

Miscellaneous databases

GenomeRNAii55366.

Gene expression databases

BgeeiQ59ER8.
GenevisibleiQ59ER8. HS.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF13855. LRR_8. 4 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
SMARTiSM00369. LRR_TYP. 15 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS51450. LRR. 15 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Aorta endothelial cellImported.

Entry informationi

Entry nameiQ59ER8_HUMAN
AccessioniPrimary (citable) accession number: Q59ER8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.