Q59ER6 (Q59ER6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Protocadherin beta 2 variant EMBL BAD92982.1
Organism	Homo sapiens (Human) EMBL BAD92982.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	784 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain By similarity. SAAS SAAS020894
Sequence similarities	Contains 6 cadherin domains. SAAS SAAS020894

Ontologies

Keywords
Biological process	Cell adhesion SAAS SAAS020894
Cellular component	Cell membrane SAAS SAAS013164 Membrane
Domain	Repeat SAAS SAAS020894 Transmembrane Transmembrane helix SAAS SAAS020894
Ligand	Calcium RuleBase RU000484 SAAS SAAS020894
Gene Ontology (GO)
Biological_process	homophilic cell adhesion Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92982.1

Sequences

	Sequence		Length	Mass (Da)
	Q59ER6 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: F7201BBC64A10B84	FASTA	784	85,655
	10 20 30 40 50 60 QVLIFFVLLG IAQASCQPRH YSVAEETESG SFVANLLKDL GLEIGELAVR GARVVSKGKK 70 80 90 100 110 120 MHLQFDRQTG DLLLNEKLDR EELCGPTEPC VLPFQVLLEN PLQFFQAELR IRDINDHSPV 130 140 150 160 170 180 FLDKEILLKI PESITPGTTF LIERAQDLDV GTNSLQNYTI SPNFHFHLNL QDSLDGIILP 190 200 210 220 230 240 QLVLNRALDR EEQPEIRLTL TALDGGSPPR SGTALVRIEV VDINDNVPEF AKLLYEVQIP 250 260 270 280 290 300 EDSPVGSQVA IVSARDLDIG TNGEISYAFS QASEDIRKTF RLSAKSGELL LRQKLDFESI 310 320 330 340 350 360 QTYTVNIQAT DGGGLSGTCV VFVQVMDLND NPPELTMSTL INQIPENLQD TLIAVFSVSD 370 380 390 400 410 420 PDSGDNGRMV CSIQDDLPFF LKPSVENFYT LVISTALDRE TRSEYNITIT VTDFGTPRLK 430 440 450 460 470 480 TEHNITVLVS DVNDNAPAFT QTSYTLFVRE NNSPALHIGS VSATDRDSGT NAQVTYSLLP 490 500 510 520 530 540 PQDPHLPLAS LVSINADNGH LFALQSLDYE ALQAFEFRVG AADRGSPALS SEALVRVLVL 550 560 570 580 590 600 DANDNSPFVL YPLQNGSAPC TELVPRAAEP GYLVTKVVAV DGDSGQNAWL SYQLLKATEP 610 620 630 640 650 660 GLFGVWAHNG EVRTARLLRE RDAAKQRLVV LVKDNGEPPR SATATLHVLL VDGFSQPYLP 670 680 690 700 710 720 LPEAAPAQAQ ADLLTVYLVV ALASVSSLFL FSVLLFVAVR LCRRSRAASV GRCSVPEGPF 730 740 750 760 770 780 PGQMVDVSGT GTLSQSYQYE VCLTGGSGTN EFKFLKPIIP NFVAQGAERV SEANPSFRKS FEFT

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta endothelial cell EMBL BAD92982.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209745 mRNA. Translation: BAD92982.1.
IPI	IPI00001432.
UniGene	Hs.533023.
3D structure databases
ProteinModelPortal	Q59ER6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59ER6.
Proteomic databases
PRIDE	Q59ER6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG054878.
Gene expression databases
ArrayExpress	Q59ER6.
Family and domain databases
Gene3D	2.60.40.60. 5 hits.
InterPro	IPR002126. Cadherin. IPR015919. Cadherin-like. IPR020894. Cadherin_CS. IPR013164. Cadherin_N. [Graphical view]
Pfam	PF00028. Cadherin. 5 hits. PF08266. Cadherin_2. 1 hit. [Graphical view]
PRINTS	PR00205. CADHERIN.
SMART	SM00112. CA. 6 hits. [Graphical view]
SUPFAM	SSF49313. Cadherin. 5 hits.
PROSITE	PS00232. CADHERIN_1. 5 hits. PS50268. CADHERIN_2. 6 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59ER6_HUMAN

Accession

Primary (citable) accession number: Q59ER6

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	March 6, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.