Unreviewed, UniProtKB/TrEMBL Q59ER4 (Q59ER4_HUMAN)

Names and origin

Protein names	Submitted name:     Itchy homolog E3 ubiquitin protein ligase variant EMBL BAD92984.1
Organism	Homo sapiens (Human) EMBL BAD92984.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	605 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Spearmint SPM000569

Ontologies

Keywords
Biological process	Ubl conjugation pathway Spearmint SPM000569
Molecular function	Ligase
Gene Ontology (GO)
Uncategorized	ubiquitin cycle Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	protein binding Inferred from electronic annotation. Source: InterPro ubiquitin-protein ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD92984.1

Sequences

	Sequence		Length	Mass (Da)
	Q59ER4-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 96C9D9C80744FB10	FASTA	605	71,394
	10 20 30 40 50 60 EGATSGLIIP LTISGGSGPR PLNPVTQAPL PPGWEQRVDQ HGRVYYVDHV EKRTTWDRPE 70 80 90 100 110 120 PLPPGWERRV DNMGRIYYVD HFTRTTTWQR PTLESVRNYE QWQLQRSQLQ GAMQQFNQRF 130 140 150 160 170 180 IYGNQDLFAT SQSKEFDPLG PLPPGWEKRT DSNGRVYFVN HNTRITQWEY PRSQGQLNEK 190 200 210 220 230 240 PLPEGWEMRF TVDGIPYFVD HNRRTTTYID PRTGKSALDN GPQIAYVRDF KAKVQYFRFW 250 260 270 280 290 300 CQQLAMPQHI KITVTRKTLF EDSFQQIMSF SPQDLRRRLW VIFPGEEGLD YGGVAREWFF 310 320 330 340 350 360 LLSHEVLNPM YCLFEYAGKD NYCLQINPAS YINPDHLKYF RFIGRFIAMA LFHGKFIDTG 370 380 390 400 410 420 FSLPFYKRIL NKPVGLKDLE SIDPEFYNSL IWVKENNIEE CDLEMYFSVD KEILGEIKSH 430 440 450 460 470 480 DLKPNGGNIL VTEENKEEYI RMVAEWRLSR GVEEQTQAFF EGFNEILPQQ YLQYFDAKEL 490 500 510 520 530 540 EVLLCGMQEI DLNDWQRHAI YRHYARTSKQ IMWFWQFVKE IDNEKRMRLL QFVTGTCRLP 550 560 570 580 590 600 VGGFADLMGS NGPQKFCIEK VGKENWLPRS HTCFNRLDLP PYKSYEQLKE KLLFAIEETE GFGQE

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta endothelial cell EMBL BAD92984.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB209747 mRNA. Translation: BAD92984.1.
UniGene	Hs.632272
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000078747. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:13890. ITCH.
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q59ER4.
Gene expression databases
ArrayExpress	Q59ER4.
Family and domain databases
InterPro	IPR000569. HECT. IPR002349. WW. IPR001202. WW_Rsp5_WWP. [Graphical view]
Pfam	PF00632. HECT. 1 hit. PF00397. WW. 4 hits. [Graphical view]
PRINTS	PR00403. WWDOMAIN.
SMART	SM00119. HECTc. 1 hit. SM00456. WW. 4 hits. [Graphical view]
PROSITE	PS50237. HECT. 1 hit. PS01159. WW_DOMAIN_1. 4 hits. PS50020. WW_DOMAIN_2. 2 hits. [Graphical view]

Entry information

Entry name

Q59ER4_HUMAN

Accession

Primary (citable) accession number: Q59ER4

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	September 23, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)