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Protein
Submitted name:

Sphingomyelin phosphodiesterase 1, acid lysosomal isoform 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Sphingomyelin phosphodiesterase 1, acid lysosomal isoform 1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei63 – 8220HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ59EN6.
PRIDEiQ59EN6.

Expressioni

Gene expression databases

GenevisibleiQ59EN6. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340409.

Structurei

3D structure databases

ProteinModelPortaliQ59EN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini120 – 20485Saposin B-typeInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3770. Eukaryota.
ENOG410YYPB. LUCA.
HOGENOMiHOG000008599.
HOVERGENiHBG004288.
KOiK12350.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
IPR011160. Sphingomy_PDE.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000948. Sphingomy_PDE. 1 hit.
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59EN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGVPGAARGP EGWLGSRPGG TGQTNQPRVG SATMPRYGAS LRQSCPRSGR
60 70 80 90 100
EQGQDGTAGA PGLLWMGLAL ALALALALAL ALSDSRVLWA PAEAHPLSPQ
110 120 130 140 150
GHPARLHRIV PRLRDVFGWG NLTCPICKGL FTAINLGLKK EPNVARVGSV
160 170 180 190 200
AIKLCNLLKI APPAVCQSIV HLFEDDMVEV WRRSVLSPSE ACGLLLGSTC
210 220 230 240 250
GHWDIFSSWN ISLPTVPKPP PKPPSPPAPG APVSRILFLT DLHWDHDYLE
260 270 280 290 300
GTDPDCADPL CCRRGSGLPP ASRPGAGYWG EYSKCDLPLR TLESLLSGLG
310 320 330 340 350
PAGPFDMVYW TGDIPAHDVW HQTRQDQLRA LTTVTALVRK FLGPVPVYPA
360 370 380 390 400
VGNHESTPVN SFPPPFIEGN HSSRWLYEAM AKAWEPWLPA EALRTLRIGG
410 420 430 440 450
FYALSPYPGL RLISLNMNFC SRENFWLLIN STDPAGQLQW LVGELQAAED
460 470 480 490 500
RGDKVHIIGH IPPGHCLKSW SWNYYRIVAR YENTLAAQFF GHTHVDEFEV
510 520 530 540 550
FYDEETLSRP LAVAFLAPSA TTYIGLNPGY RVYQIDGNYS GSSHVVLDHE
560 570 580 590 600
TYILNLTQAN IPGAIPHWQL LYRARETYGL PNTLPTAWHN LVYRMRGDMQ
610 620 630 640 650
LFQTFWFLYH KGHPPSEPCG TPCRLATLCA QLSARADSPA LCRHLMPDGS
660
LPEAQSLWPR PLFC
Length:664
Mass (Da):73,054
Last modified:April 26, 2005 - v1
Checksum:iB361244D57C8B24D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209775 mRNA. Translation: BAD93012.1.
RefSeqiNP_000534.3. NM_000543.4.
NP_001007594.2. NM_001007593.2.
NP_001305017.1. NM_001318088.1.
UniGeneiHs.498173.

Genome annotation databases

GeneIDi6609.
KEGGihsa:6609.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209775 mRNA. Translation: BAD93012.1.
RefSeqiNP_000534.3. NM_000543.4.
NP_001007594.2. NM_001007593.2.
NP_001305017.1. NM_001318088.1.
UniGeneiHs.498173.

3D structure databases

ProteinModelPortaliQ59EN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340409.

Proteomic databases

PaxDbiQ59EN6.
PRIDEiQ59EN6.

Protocols and materials databases

DNASUi6609.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6609.
KEGGihsa:6609.

Organism-specific databases

CTDi6609.

Phylogenomic databases

eggNOGiKOG3770. Eukaryota.
ENOG410YYPB. LUCA.
HOGENOMiHOG000008599.
HOVERGENiHBG004288.
KOiK12350.

Miscellaneous databases

GenomeRNAii6609.

Gene expression databases

GenevisibleiQ59EN6. HS.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
IPR011160. Sphingomy_PDE.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000948. Sphingomy_PDE. 1 hit.
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ59EN6_HUMAN
AccessioniPrimary (citable) accession number: Q59EN6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 8, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.