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Protein
Submitted name:

Sphingomyelin phosphodiesterase 1, acid lysosomal isoform 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi241Zinc 1UniRule annotation1
Metal bindingi243Zinc 1; via tele nitrogenUniRule annotation1
Metal bindingi313Zinc 1UniRule annotation1
Metal bindingi313Zinc 2UniRule annotation1
Metal bindingi353Zinc 2UniRule annotation1
Metal bindingi460Zinc 2; via tele nitrogenUniRule annotation1
Metal bindingi492Zinc 2; via pros nitrogenUniRule annotation1
Metal bindingi494Zinc 1; via tele nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Sphingomyelin phosphodiesterase 1, acid lysosomal isoform 1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei63 – 82HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi124 ↔ 200UniRule annotation
Disulfide bondi127 ↔ 192UniRule annotation
Disulfide bondi155 ↔ 166UniRule annotation
Disulfide bondi256 ↔ 261UniRule annotation
Disulfide bondi262 ↔ 285UniRule annotation
Disulfide bondi420 ↔ 466UniRule annotation
Disulfide bondi619 ↔ 623UniRule annotation
Disulfide bondi629 ↔ 642UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Proteomic databases

PaxDbiQ59EN6.
PeptideAtlasiQ59EN6.
PRIDEiQ59EN6.

Expressioni

Gene expression databases

GenevisibleiQ59EN6. HS.

Structurei

3D structure databases

ProteinModelPortaliQ59EN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 204Saposin B-typeInterPro annotationAdd BLAST85

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3770. Eukaryota.
ENOG410YYPB. LUCA.
HOGENOMiHOG000008599.
HOVERGENiHBG004288.
KOiK12350.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
3.60.21.10. 1 hit.
InterProiView protein in InterPro
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR011001. Saposin-like.
IPR008139. SaposinB_dom.
IPR011160. Sphingomy_PDE.
PfamiView protein in Pfam
PF00149. Metallophos. 1 hit.
PIRSFiPIRSF000948. Sphingomy_PDE. 1 hit.
SMARTiView protein in SMART
SM00741. SapB. 1 hit.
SUPFAMiSSF47862. SSF47862. 1 hit.
SSF56300. SSF56300. 1 hit.
PROSITEiView protein in PROSITE
PS50015. SAP_B. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59EN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SGVPGAARGP EGWLGSRPGG TGQTNQPRVG SATMPRYGAS LRQSCPRSGR
60 70 80 90 100
EQGQDGTAGA PGLLWMGLAL ALALALALAL ALSDSRVLWA PAEAHPLSPQ
110 120 130 140 150
GHPARLHRIV PRLRDVFGWG NLTCPICKGL FTAINLGLKK EPNVARVGSV
160 170 180 190 200
AIKLCNLLKI APPAVCQSIV HLFEDDMVEV WRRSVLSPSE ACGLLLGSTC
210 220 230 240 250
GHWDIFSSWN ISLPTVPKPP PKPPSPPAPG APVSRILFLT DLHWDHDYLE
260 270 280 290 300
GTDPDCADPL CCRRGSGLPP ASRPGAGYWG EYSKCDLPLR TLESLLSGLG
310 320 330 340 350
PAGPFDMVYW TGDIPAHDVW HQTRQDQLRA LTTVTALVRK FLGPVPVYPA
360 370 380 390 400
VGNHESTPVN SFPPPFIEGN HSSRWLYEAM AKAWEPWLPA EALRTLRIGG
410 420 430 440 450
FYALSPYPGL RLISLNMNFC SRENFWLLIN STDPAGQLQW LVGELQAAED
460 470 480 490 500
RGDKVHIIGH IPPGHCLKSW SWNYYRIVAR YENTLAAQFF GHTHVDEFEV
510 520 530 540 550
FYDEETLSRP LAVAFLAPSA TTYIGLNPGY RVYQIDGNYS GSSHVVLDHE
560 570 580 590 600
TYILNLTQAN IPGAIPHWQL LYRARETYGL PNTLPTAWHN LVYRMRGDMQ
610 620 630 640 650
LFQTFWFLYH KGHPPSEPCG TPCRLATLCA QLSARADSPA LCRHLMPDGS
660
LPEAQSLWPR PLFC
Length:664
Mass (Da):73,054
Last modified:April 26, 2005 - v1
Checksum:iB361244D57C8B24D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209775 mRNA. Translation: BAD93012.1.
RefSeqiNP_000534.3. NM_000543.4.
NP_001007594.2. NM_001007593.2.
NP_001305017.1. NM_001318088.1.
UniGeneiHs.498173.

Genome annotation databases

GeneIDi6609.
KEGGihsa:6609.

Similar proteinsi

Entry informationi

Entry nameiQ59EN6_HUMAN
AccessioniPrimary (citable) accession number: Q59EN6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 25, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.