ID   Q59EH0_HUMAN            Unreviewed;      1105 AA.
AC   Q59EH0;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   27-MAR-2024, entry version 103.
DE   SubName: Full=Myosin IXA variant {ECO:0000313|EMBL:BAD93078.1};
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD93078.1};
RN   [1] {ECO:0000313|EMBL:BAD93078.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Aorta endothelial cell {ECO:0000313|EMBL:BAD93078.1};
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell projection, growth cone
CC       {ECO:0000256|ARBA:ARBA00004624}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR   EMBL; AB209841; BAD93078.1; -; mRNA.
DR   AlphaFoldDB; Q59EH0; -.
DR   PeptideAtlas; Q59EH0; -.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0000146; F:microfilament motor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd01385; MYSc_Myo9; 1.
DR   Gene3D; 1.10.10.820; -; 1.
DR   Gene3D; 1.20.5.190; -; 2.
DR   Gene3D; 1.20.58.530; -; 2.
DR   Gene3D; 6.20.240.20; -; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 2.
DR   Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR046987; Myo9.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR036023; MYSc_Myo9.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR46184:SF3; UNCONVENTIONAL MYOSIN-IXA; 1.
DR   PANTHER; PTHR46184; UNCONVENTIONAL MYOSIN-IXB-LIKE PROTEIN; 1.
DR   Pfam; PF00612; IQ; 3.
DR   Pfam; PF00063; Myosin_head; 2.
DR   Pfam; PF00788; RA; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00015; IQ; 4.
DR   SMART; SM00242; MYSc; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50096; IQ; 3.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS50200; RA; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00782}; GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Membrane {ECO:0000256|ARBA:ARBA00022989};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW   ProRule:PRU00782};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00782}; Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          1..87
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          121..972
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000259|PROSITE:PS51456"
FT   REGION          854..876
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT   BINDING         214..221
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAD93078.1"
SQ   SEQUENCE   1105 AA;  129008 MW;  BE722276888D0ABA CRC64;
     SEGTIYCPIP ARKNSTAAEV IESLINKLHL DKTKCYVLAE VKEFGGEEWI LNPTDCPVQR
     MMLWPRMALE NRLSGEDYRF LLREKNLDGS IHYGSLQSWL RVTEERRRMM ERGFLPQPQQ
     KDFDDLCSLP DLNEKTLLEN LRNRFKHEKI YTYVGSILIV INPFKFLPIY NPKYVKMYDN
     HQLGKLEPHI YAVADVAYHA MLQRKKNQCI VISGESGSGK TQSTNFLIHH LTALSQKGFA
     SGVEQIILGA GPVLEAFGNA KTAHNNNSSR FGKFIQVNYQ ETGTVLGAYV EKYLLEKSRL
     VYQEHNERNY HVFYYLLAGA SEDERSAFHL KQPEEYHYLN QDCFTVEGED LRHDFERLQL
     AMEMVGFLPK TRRQIFSLLS AILHLGNICY KKKTYRDDSI DICNPEVLPI VSELLEVKEE
     MLFEALVTRK TVTVGEKLIL PYKLAEAVTV RNSMAKSLYS ALFDWIVFRI NHALLNSKDL
     EHNTKTLSIG VLDIFGFEDY ENNSFEQFCI NFANERLQHY FNQHIFKLEQ EEYRTEGISW
     HNIDYIDNTC CINLISKKPT GLLHLLDEES NFPQATNQTL LDKFKHQHED NSYIEFPAVM
     EPAFIIKHYA GKVKYGVKDF REKNTDHMRP DIVALLRSSK NAFISGMIGI DPVAVFRWAI
     LRAFFRAMVA FREAGKRNIH RKTGHDDTAP CAILKSMDSF SFLQHPVHQR SLEILQRCKE
     EKYSITRKNP RTPLSDLQGM NALNEKNQHD TFDIAWNGRT GIRQSRLSSG TSLLDKDGIF
     ANSTSSKLLE RAHGILTRNK NFKSKPALPK HLLEVNSLKH LTRLTLQDRI TKSLLHLHKK
     KKPPSISAQF QASLSKLMET LGQAEPYFVK CIRSNAEKLP LRFSDVLVLR QLRYTGMLET
     VRIRQSGYSS KYSFQDFVSH FHVLLPRNII PSKFNIQDFF RKINLNPDNY QVGKTMVFLK
     EQERQHLQDL LHQEVLRRII LLQRWFRVLL CRQHFLHLRQ ASVIIQRFWR NYLNQKQVRD
     AAVQKDAFVM ASAAALLQAS WRAHLERQRY LELRAAAIVI QQKWRDYYRR RHMAAICIQA
     RWKAYRESKR YQEQRKKNYP FAINM
//