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Protein
Submitted name:

Myosin IXA variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi214 – 221ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotationSAAS annotation
LigandATP-bindingSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Myosin IXA variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ59EH0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 87Ras-associatingInterPro annotationAdd BLAST87
Domaini121 – 972Myosin motorInterPro annotationAdd BLAST852

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni854 – 876Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1453 Eukaryota
KOG4229 Eukaryota
COG5022 LUCA
HOGENOMiHOG000113707
HOVERGENiHBG052558

Family and domain databases

CDDicd01385 MYSc_Myo9, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR028558 MYO9A
IPR001609 Myosin_head_motor_dom
IPR036023 MYSc_Myo9
IPR027417 P-loop_NTPase
IPR000159 RA_dom
IPR029071 Ubiquitin-like_domsf
PANTHERiPTHR13140:SF9 PTHR13140:SF9, 1 hit
PfamiView protein in Pfam
PF00612 IQ, 3 hits
PF00063 Myosin_head, 2 hits
PF00788 RA, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 4 hits
SM00242 MYSc, 1 hit
SM00314 RA, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 3 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS50200 RA, 1 hit

Sequencei

Sequence statusi: Fragment.

Q59EH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
SEGTIYCPIP ARKNSTAAEV IESLINKLHL DKTKCYVLAE VKEFGGEEWI
60 70 80 90 100
LNPTDCPVQR MMLWPRMALE NRLSGEDYRF LLREKNLDGS IHYGSLQSWL
110 120 130 140 150
RVTEERRRMM ERGFLPQPQQ KDFDDLCSLP DLNEKTLLEN LRNRFKHEKI
160 170 180 190 200
YTYVGSILIV INPFKFLPIY NPKYVKMYDN HQLGKLEPHI YAVADVAYHA
210 220 230 240 250
MLQRKKNQCI VISGESGSGK TQSTNFLIHH LTALSQKGFA SGVEQIILGA
260 270 280 290 300
GPVLEAFGNA KTAHNNNSSR FGKFIQVNYQ ETGTVLGAYV EKYLLEKSRL
310 320 330 340 350
VYQEHNERNY HVFYYLLAGA SEDERSAFHL KQPEEYHYLN QDCFTVEGED
360 370 380 390 400
LRHDFERLQL AMEMVGFLPK TRRQIFSLLS AILHLGNICY KKKTYRDDSI
410 420 430 440 450
DICNPEVLPI VSELLEVKEE MLFEALVTRK TVTVGEKLIL PYKLAEAVTV
460 470 480 490 500
RNSMAKSLYS ALFDWIVFRI NHALLNSKDL EHNTKTLSIG VLDIFGFEDY
510 520 530 540 550
ENNSFEQFCI NFANERLQHY FNQHIFKLEQ EEYRTEGISW HNIDYIDNTC
560 570 580 590 600
CINLISKKPT GLLHLLDEES NFPQATNQTL LDKFKHQHED NSYIEFPAVM
610 620 630 640 650
EPAFIIKHYA GKVKYGVKDF REKNTDHMRP DIVALLRSSK NAFISGMIGI
660 670 680 690 700
DPVAVFRWAI LRAFFRAMVA FREAGKRNIH RKTGHDDTAP CAILKSMDSF
710 720 730 740 750
SFLQHPVHQR SLEILQRCKE EKYSITRKNP RTPLSDLQGM NALNEKNQHD
760 770 780 790 800
TFDIAWNGRT GIRQSRLSSG TSLLDKDGIF ANSTSSKLLE RAHGILTRNK
810 820 830 840 850
NFKSKPALPK HLLEVNSLKH LTRLTLQDRI TKSLLHLHKK KKPPSISAQF
860 870 880 890 900
QASLSKLMET LGQAEPYFVK CIRSNAEKLP LRFSDVLVLR QLRYTGMLET
910 920 930 940 950
VRIRQSGYSS KYSFQDFVSH FHVLLPRNII PSKFNIQDFF RKINLNPDNY
960 970 980 990 1000
QVGKTMVFLK EQERQHLQDL LHQEVLRRII LLQRWFRVLL CRQHFLHLRQ
1010 1020 1030 1040 1050
ASVIIQRFWR NYLNQKQVRD AAVQKDAFVM ASAAALLQAS WRAHLERQRY
1060 1070 1080 1090 1100
LELRAAAIVI QQKWRDYYRR RHMAAICIQA RWKAYRESKR YQEQRKKNYP

FAINM
Length:1,105
Mass (Da):129,008
Last modified:April 26, 2005 - v1
Checksum:iBE722276888D0ABA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209841 mRNA Translation: BAD93078.1
UniGeneiHs.513000
Hs.546268
Hs.733087

Similar proteinsi

Entry informationi

Entry nameiQ59EH0_HUMAN
AccessioniPrimary (citable) accession number: Q59EH0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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Main funding by: National Institutes of Health