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Protein
Submitted name:

MutL protein homolog 1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
MutL protein homolog 1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PaxDbiQ59EG3.
PeptideAtlasiQ59EG3.
PRIDEiQ59EG3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000231790.

Structurei

3D structure databases

ProteinModelPortaliQ59EG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 200120DNA_mis_repairInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1979. Eukaryota.
COG0323. LUCA.
HOGENOMiHOG000176000.
HOVERGENiHBG006374.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR003594. HATPase_C.
IPR032189. Mlh1_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF01119. DNA_mis_repair. 1 hit.
PF16413. Mlh1_C. 2 hits.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59EG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KPLLNHVLAI KGPRSRWRTF FYNIATRRKA LKNPSEEYGK ILEVVGRYSV
60 70 80 90 100
HNAGISFSVK KQGETVADVR TLPNASTVDN IRSIFGNAVS RELIEIGCED
110 120 130 140 150
KTLAFKMNGY ISNANYSVKK CIFLLFINHR LVESTSLRKA IETVYAAYLP
160 170 180 190 200
KNTHPFLYLS LEISPQNVDV NVHPTKHEVH FLHEESILER VQQHIESKLL
210 220 230 240 250
GSNSSRMYFT QTLLPGLAGP SGEMVKSTTS LTSSSTSGSS DKVYAHQMVR
260 270 280 290 300
TDSREQKLDA FLQPLSKPLS SQPQAIVTED KTDISSGRAR QQDEEMLELP
310 320 330 340 350
APAEVAAKNQ SLEGDTTKGT SEMSEKRGPT SSNPRKRHRE DSDVEMVEDD
360 370 380 390 400
SRKEMTAACT PRRRIINLTS VLSLQEEINE QGHEVLREML HNHSFVGCVN
410 420 430 440 450
PQWALAQHQT KLYLLNTTKL SEELFYQILI YDFANFGVLR LSEPAPLFDL
460 470 480 490 500
AMLALDSPES GWTEEDGPKE GLAEYIVEFL KKKAEMLADY FSLEIDESEV
510 520 530 540 550
PGSIPNSWKW TVEHIVYKAL RSHILPPKHF TEDGNILQLA NLPDLYKVFE

RC
Length:552
Mass (Da):62,370
Last modified:April 26, 2005 - v1
Checksum:i01E87FCC54DBF6F8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209848 mRNA. Translation: BAD93085.1.
RefSeqiNP_001245200.1. NM_001258271.1.
UniGeneiHs.195364.

Genome annotation databases

GeneIDi4292.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209848 mRNA. Translation: BAD93085.1.
RefSeqiNP_001245200.1. NM_001258271.1.
UniGeneiHs.195364.

3D structure databases

ProteinModelPortaliQ59EG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000231790.

Proteomic databases

PaxDbiQ59EG3.
PeptideAtlasiQ59EG3.
PRIDEiQ59EG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4292.

Organism-specific databases

CTDi4292.

Phylogenomic databases

eggNOGiKOG1979. Eukaryota.
COG0323. LUCA.
HOGENOMiHOG000176000.
HOVERGENiHBG006374.

Miscellaneous databases

GenomeRNAii4292.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
InterProiIPR013507. DNA_mismatch_repair_C.
IPR003594. HATPase_C.
IPR032189. Mlh1_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamiPF01119. DNA_mis_repair. 1 hit.
PF16413. Mlh1_C. 2 hits.
[Graphical view]
SMARTiSM01340. DNA_mis_repair. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ59EG3_HUMAN
AccessioniPrimary (citable) accession number: Q59EG3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 6, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.