Q59EF9 (Q59EF9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Neuroepithelial cell transforming gene 1 protein variant EMBL BAD93089.1
Organism	Homo sapiens (Human) EMBL BAD93089.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	624 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. SAAS SAAS001331 Contains 1 PH domain. RuleBase RU003350

Ontologies

Gene Ontology (GO)
Biological process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD93089.1

Sequences

	Sequence		Length	Mass (Da)
	Q59EF9 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 08708AE60B6B07EE	FASTA	624	70,619
	10 20 30 40 50 60 SAWQRLAGIV PVPAGLPGTR PPPHPLLRAM EPELAAQKQP RPRRRSRRAS GLSTEGATGP 70 80 90 100 110 120 SADTSGSELD GRCSLRRGSS FTFLTPGPNW DFTLKRKRRE KDDDVVSLSS LDLKEPSNKR 130 140 150 160 170 180 VRPLARVTSL ANLISPVRNG AVRRFGQTIQ SFTLRGDHRS PASAQKFSSR STVPTPAKRR 190 200 210 220 230 240 SSALWSEMLD ITMKESLTTR EIRRQEAIYE MSRGEQDLIE DLKLARKAYH DPMLKLSIMS 250 260 270 280 290 300 EEELTHIFGD LDSYIPLHED LLTRIGEATK PDGTVEQIGH ILVSWLPRLN AYRGYCSNQL 310 320 330 340 350 360 AAKALLDQKK QDPRVQDFLQ RCLESPFSRK LDLWSFLDIP RSRLVKYPLL LKEILKHTPK 370 380 390 400 410 420 EHPDVQLLED AILIIQGVLS DINLKKGESE CQYYIDKLEY LDEKQRDPRI EASKVLLCHG 430 440 450 460 470 480 ELRSKSGHKL YIFLFDILVL TRPVTRNERH SYQVYRQPIP VQELVLEDLQ DGDVRMGGSF 490 500 510 520 530 540 RGAFSNSEKA KNIFRIRFHD PSPAQSHTLQ ANDVFHKQQW FNCIRAAIAP FQSAGSPPEL 550 560 570 580 590 600 QGLPELHEEC EGNHPSARKL TAQRRASTVS SVTQVEVDEN AYRCGSGMQM AEDSKSLKTH 610 620 QTQPGIRRAR DKALSGGKRK ETLV

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta endothelial cell EMBL BAD93089.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209852 Transcribed RNA. Translation: BAD93089.1.
IPI	IPI00385312.
UniGene	Hs.25155.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q59EF9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HBG713528.
HOVERGEN	HBG050567.
Gene expression databases
ArrayExpress	Q59EF9.
Family and domain databases
InterPro	IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR011993. PH_type. IPR001849. Pleckstrin_homology. IPR015721. RhoGEF-like. [Graphical view]
Gene3D	G3DSA:2.30.29.30. PH_type. 1 hit. G3DSA:1.20.900.10. RhoGEF. 1 hit.
PANTHER	PTHR22825. RhoGEF_like. 1 hit.
Pfam	PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit.
PROSITE	PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59EF9_HUMAN

Accession

Primary (citable) accession number: Q59EF9

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	November 16, 2011
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.