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Protein
Submitted name:

Calpain 2, large [catalytic] subunit variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei134PROSITE-ProRule annotation1
Active sitei291PROSITE-ProRule annotation1
Active sitei315PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi614 – 625PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi644 – 655PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteasePROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain 2, large [catalytic] subunit variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26060.

PTM / Processingi

Proteomic databases

PaxDbiQ59EF6.
PeptideAtlasiQ59EF6.
PRIDEiQ59EF6.

Expressioni

Gene expression databases

GenevisibleiQ59EF6. HS.

Interactioni

Protein-protein interaction databases

MINTiMINT-5000600.

Structurei

3D structure databases

ProteinModelPortaliQ59EF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 373Calpain catalyticInterPro annotationAdd BLAST300
Domaini601 – 626EF-handInterPro annotationAdd BLAST26
Domaini631 – 666EF-handInterPro annotationAdd BLAST36
Domaini696 – 729EF-handInterPro annotationAdd BLAST34

Sequence similaritiesi

Belongs to the peptidase C2 family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0045. Eukaryota.
ENOG410XP0B. LUCA.
HOGENOMiHOG000232035.
HOVERGENiHBG012645.
KOiK03853.

Family and domain databases

CDDicd00214. Calpain_III. 1 hit.
cd00044. CysPc. 1 hit.
InterProiView protein in InterPro
IPR033883. C2_III.
IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR036213. Calpain_III_sf.
IPR029539. CAPN2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
PANTHERiPTHR10183:SF268. PTHR10183:SF268. 1 hit.
PfamiView protein in Pfam
PF01067. Calpain_III. 1 hit.
PF13833. EF-hand_8. 1 hit.
PF00648. Peptidase_C2. 1 hit.
PRINTSiPR00704. CALPAIN.
SMARTiView protein in SMART
SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
SSF49758. SSF49758. 1 hit.
PROSITEiView protein in PROSITE
PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 3 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q59EF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
APGPGRAPAE RSAESPRPFS AQYGRRDRSM AGIAAKLAKD REAAEGLGSH
60 70 80 90 100
ERAIKYLNQD YEALRNECLE AGTLFQDPSF PAIPSALGFK ELGPYSSKTR
110 120 130 140 150
GIEWKRPTEI CADPQFIIGG ATRTDICQGA LGDCWLLAAI ASLTLNEEIL
160 170 180 190 200
ARVVPLNQCF QENYAGIFHF QFWQYGEWVE VVVDDRLPTK DGELLFVHSA
210 220 230 240 250
EGSEFWSALL EKAYAKINGC YEALSGGATT EGFEDFTGGI AEWYESKKPP
260 270 280 290 300
PNLFKIIQKA LQKGSLLGCS IDITSAADSE AITFQKLVKG HAYSVTGAEE
310 320 330 340 350
VESNGSLQKL IRIRNPWGEV EWTGRWNDNC PSWNTIDPEE RERLTRRHED
360 370 380 390 400
GEFWMSFSDF LRHYSRLEIC NLTPDTLTSD TYKKWKLTKM DGNWRRGSTA
410 420 430 440 450
GGCRNYPNTF WMNPQYLIKL EEEDEDEEDG ESGCTFLVGL IQKHRRRQRK
460 470 480 490 500
MGEDMHTIGF GIYEVPEELS GQTNIHLSKN FFLTNRARER SDTFINLREV
510 520 530 540 550
LNRFKLPPGE YILVPSTFEP NKDGDFCIRV FSEKKADYQA VDDEIEANLE
560 570 580 590 600
EFDISEDDID DGFRRLFAQL AGEDAEISAF ELQTILRRVL AKRQDIKSDG
610 620 630 640 650
FSIETCKIMV DMLDSDGSGK LGLKEFYILW TKIQKYQKIY REIDVDRSGT
660 670 680 690 700
MNSYEMRKAL EEAGFKMPCQ LHQVIVARFA DDQLIIDFDN FVRCLVRLET
710 720
LFKIFKQLDP ENTGTIELDL ISWLCFSVL
Length:729
Mass (Da):83,109
Last modified:April 26, 2005 - v1
Checksum:i39E151FF908DB2F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209855 mRNA. Translation: BAD93092.1.
RefSeqiNP_001139540.1. NM_001146068.1.
NP_001739.2. NM_001748.4.
UniGeneiHs.350899.

Genome annotation databases

GeneIDi824.
KEGGihsa:824.

Similar proteinsi

Entry informationi

Entry nameiQ59EF6_HUMAN
AccessioniPrimary (citable) accession number: Q59EF6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 25, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation