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Q59EF6

- Q59EF6_HUMAN

UniProt

Q59EF6 - Q59EF6_HUMAN

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Protein
Submitted name:

Calpain 2, large [catalytic] subunit variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium-dependent cysteine-type endopeptidase activity Source: InterPro
  2. calcium ion binding Source: InterPro

GO - Biological processi

  1. regulation of cytoskeleton organization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol proteaseSAAS annotation

Keywords - Ligandi

CalciumUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Calpain 2, large [catalytic] subunit variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26060.

PTM / Processingi

Proteomic databases

PRIDEiQ59EF6.

Interactioni

Protein-protein interaction databases

MINTiMINT-5000600.

Structurei

3D structure databases

ProteinModelPortaliQ59EF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000232035.
HOVERGENiHBG012645.
KOiK03853.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029539. CAPN2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERiPTHR10183:SF268. PTHR10183:SF268. 1 hit.
PfamiPF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSiPR00704. CALPAIN.
SMARTiSM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF49758. SSF49758. 1 hit.
PROSITEiPS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59EF6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
APGPGRAPAE RSAESPRPFS AQYGRRDRSM AGIAAKLAKD REAAEGLGSH
60 70 80 90 100
ERAIKYLNQD YEALRNECLE AGTLFQDPSF PAIPSALGFK ELGPYSSKTR
110 120 130 140 150
GIEWKRPTEI CADPQFIIGG ATRTDICQGA LGDCWLLAAI ASLTLNEEIL
160 170 180 190 200
ARVVPLNQCF QENYAGIFHF QFWQYGEWVE VVVDDRLPTK DGELLFVHSA
210 220 230 240 250
EGSEFWSALL EKAYAKINGC YEALSGGATT EGFEDFTGGI AEWYESKKPP
260 270 280 290 300
PNLFKIIQKA LQKGSLLGCS IDITSAADSE AITFQKLVKG HAYSVTGAEE
310 320 330 340 350
VESNGSLQKL IRIRNPWGEV EWTGRWNDNC PSWNTIDPEE RERLTRRHED
360 370 380 390 400
GEFWMSFSDF LRHYSRLEIC NLTPDTLTSD TYKKWKLTKM DGNWRRGSTA
410 420 430 440 450
GGCRNYPNTF WMNPQYLIKL EEEDEDEEDG ESGCTFLVGL IQKHRRRQRK
460 470 480 490 500
MGEDMHTIGF GIYEVPEELS GQTNIHLSKN FFLTNRARER SDTFINLREV
510 520 530 540 550
LNRFKLPPGE YILVPSTFEP NKDGDFCIRV FSEKKADYQA VDDEIEANLE
560 570 580 590 600
EFDISEDDID DGFRRLFAQL AGEDAEISAF ELQTILRRVL AKRQDIKSDG
610 620 630 640 650
FSIETCKIMV DMLDSDGSGK LGLKEFYILW TKIQKYQKIY REIDVDRSGT
660 670 680 690 700
MNSYEMRKAL EEAGFKMPCQ LHQVIVARFA DDQLIIDFDN FVRCLVRLET
710 720
LFKIFKQLDP ENTGTIELDL ISWLCFSVL
Length:729
Mass (Da):83,109
Last modified:April 26, 2005 - v1
Checksum:i39E151FF908DB2F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209855 mRNA. Translation: BAD93092.1.
RefSeqiNP_001139540.1. NM_001146068.1.
NP_001739.2. NM_001748.4.
UniGeneiHs.350899.

Genome annotation databases

GeneIDi824.
KEGGihsa:824.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209855 mRNA. Translation: BAD93092.1 .
RefSeqi NP_001139540.1. NM_001146068.1.
NP_001739.2. NM_001748.4.
UniGenei Hs.350899.

3D structure databases

ProteinModelPortali Q59EF6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-5000600.

Proteomic databases

PRIDEi Q59EF6.

Protocols and materials databases

DNASUi 824.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 824.
KEGGi hsa:824.

Organism-specific databases

CTDi 824.
PharmGKBi PA26060.

Phylogenomic databases

HOGENOMi HOG000232035.
HOVERGENi HBG012645.
KOi K03853.

Miscellaneous databases

GenomeRNAii 824.
NextBioi 3374.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR029539. CAPN2.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view ]
PANTHERi PTHR10183:SF268. PTHR10183:SF268. 1 hit.
Pfami PF01067. Calpain_III. 1 hit.
PF00648. Peptidase_C2. 1 hit.
[Graphical view ]
PRINTSi PR00704. CALPAIN.
SMARTi SM00720. calpain_III. 1 hit.
SM00230. CysPc. 1 hit.
SM00054. EFh. 3 hits.
[Graphical view ]
SUPFAMi SSF49758. SSF49758. 1 hit.
PROSITEi PS50203. CALPAIN_CAT. 1 hit.
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 3 hits.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Aorta endothelial cellImported.

Entry informationi

Entry nameiQ59EF6_HUMAN
AccessioniPrimary (citable) accession number: Q59EF6
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.