Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q59EF6

- Q59EF6_HUMAN

UniProt

Q59EF6 - Q59EF6_HUMAN

Protein
Submitted name:

Calpain 2, large [catalytic] subunit variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: InterPro
    2. calcium ion binding Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol proteaseSAAS annotation

    Keywords - Ligandi

    CalciumUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Calpain 2, large [catalytic] subunit variantImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26060.

    PTM / Processingi

    Proteomic databases

    PRIDEiQ59EF6.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-5000600.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59EF6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000232035.
    HOVERGENiHBG012645.
    KOiK03853.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR029539. CAPN2.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PANTHERiPTHR10183:SF268. PTHR10183:SF268. 1 hit.
    PfamiPF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    SM00054. EFh. 3 hits.
    [Graphical view]
    SUPFAMiSSF49758. SSF49758. 1 hit.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q59EF6-1 [UniParc]FASTAAdd to Basket

    « Hide

    APGPGRAPAE RSAESPRPFS AQYGRRDRSM AGIAAKLAKD REAAEGLGSH    50
    ERAIKYLNQD YEALRNECLE AGTLFQDPSF PAIPSALGFK ELGPYSSKTR 100
    GIEWKRPTEI CADPQFIIGG ATRTDICQGA LGDCWLLAAI ASLTLNEEIL 150
    ARVVPLNQCF QENYAGIFHF QFWQYGEWVE VVVDDRLPTK DGELLFVHSA 200
    EGSEFWSALL EKAYAKINGC YEALSGGATT EGFEDFTGGI AEWYESKKPP 250
    PNLFKIIQKA LQKGSLLGCS IDITSAADSE AITFQKLVKG HAYSVTGAEE 300
    VESNGSLQKL IRIRNPWGEV EWTGRWNDNC PSWNTIDPEE RERLTRRHED 350
    GEFWMSFSDF LRHYSRLEIC NLTPDTLTSD TYKKWKLTKM DGNWRRGSTA 400
    GGCRNYPNTF WMNPQYLIKL EEEDEDEEDG ESGCTFLVGL IQKHRRRQRK 450
    MGEDMHTIGF GIYEVPEELS GQTNIHLSKN FFLTNRARER SDTFINLREV 500
    LNRFKLPPGE YILVPSTFEP NKDGDFCIRV FSEKKADYQA VDDEIEANLE 550
    EFDISEDDID DGFRRLFAQL AGEDAEISAF ELQTILRRVL AKRQDIKSDG 600
    FSIETCKIMV DMLDSDGSGK LGLKEFYILW TKIQKYQKIY REIDVDRSGT 650
    MNSYEMRKAL EEAGFKMPCQ LHQVIVARFA DDQLIIDFDN FVRCLVRLET 700
    LFKIFKQLDP ENTGTIELDL ISWLCFSVL 729
    Length:729
    Mass (Da):83,109
    Last modified:April 26, 2005 - v1
    Checksum:i39E151FF908DB2F7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209855 mRNA. Translation: BAD93092.1.
    RefSeqiNP_001139540.1. NM_001146068.1.
    NP_001739.2. NM_001748.4.
    UniGeneiHs.350899.

    Genome annotation databases

    GeneIDi824.
    KEGGihsa:824.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209855 mRNA. Translation: BAD93092.1 .
    RefSeqi NP_001139540.1. NM_001146068.1.
    NP_001739.2. NM_001748.4.
    UniGenei Hs.350899.

    3D structure databases

    ProteinModelPortali Q59EF6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-5000600.

    Proteomic databases

    PRIDEi Q59EF6.

    Protocols and materials databases

    DNASUi 824.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 824.
    KEGGi hsa:824.

    Organism-specific databases

    CTDi 824.
    PharmGKBi PA26060.

    Phylogenomic databases

    HOGENOMi HOG000232035.
    HOVERGENi HBG012645.
    KOi K03853.

    Miscellaneous databases

    GenomeRNAii 824.
    NextBioi 3374.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR029539. CAPN2.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    PANTHERi PTHR10183:SF268. PTHR10183:SF268. 1 hit.
    Pfami PF01067. Calpain_III. 1 hit.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00720. calpain_III. 1 hit.
    SM00230. CysPc. 1 hit.
    SM00054. EFh. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49758. SSF49758. 1 hit.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 3 hits.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Aorta endothelial cellImported.

    Entry informationi

    Entry nameiQ59EF6_HUMAN
    AccessioniPrimary (citable) accession number: Q59EF6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.