Q59EF6 (Q59EF6_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Calpain 2, large [catalytic] subunit variant EMBL BAD93092.1
Organism	Homo sapiens (Human) EMBL BAD93092.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	729 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 calpain catalytic domain. SAAS SAAS022683

Ontologies

Keywords
Ligand	Calcium RuleBase RU000331
Molecular function	Hydrolase Protease Thiol protease SAAS SAAS001300
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro calcium-dependent cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD93092.1

Sequences

	Sequence		Length	Mass (Da)
	Q59EF6 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 39E151FF908DB2F7	FASTA	729	83,109
	10 20 30 40 50 60 APGPGRAPAE RSAESPRPFS AQYGRRDRSM AGIAAKLAKD REAAEGLGSH ERAIKYLNQD 70 80 90 100 110 120 YEALRNECLE AGTLFQDPSF PAIPSALGFK ELGPYSSKTR GIEWKRPTEI CADPQFIIGG 130 140 150 160 170 180 ATRTDICQGA LGDCWLLAAI ASLTLNEEIL ARVVPLNQCF QENYAGIFHF QFWQYGEWVE 190 200 210 220 230 240 VVVDDRLPTK DGELLFVHSA EGSEFWSALL EKAYAKINGC YEALSGGATT EGFEDFTGGI 250 260 270 280 290 300 AEWYESKKPP PNLFKIIQKA LQKGSLLGCS IDITSAADSE AITFQKLVKG HAYSVTGAEE 310 320 330 340 350 360 VESNGSLQKL IRIRNPWGEV EWTGRWNDNC PSWNTIDPEE RERLTRRHED GEFWMSFSDF 370 380 390 400 410 420 LRHYSRLEIC NLTPDTLTSD TYKKWKLTKM DGNWRRGSTA GGCRNYPNTF WMNPQYLIKL 430 440 450 460 470 480 EEEDEDEEDG ESGCTFLVGL IQKHRRRQRK MGEDMHTIGF GIYEVPEELS GQTNIHLSKN 490 500 510 520 530 540 FFLTNRARER SDTFINLREV LNRFKLPPGE YILVPSTFEP NKDGDFCIRV FSEKKADYQA 550 560 570 580 590 600 VDDEIEANLE EFDISEDDID DGFRRLFAQL AGEDAEISAF ELQTILRRVL AKRQDIKSDG 610 620 630 640 650 660 FSIETCKIMV DMLDSDGSGK LGLKEFYILW TKIQKYQKIY REIDVDRSGT MNSYEMRKAL 670 680 690 700 710 720 EEAGFKMPCQ LHQVIVARFA DDQLIIDFDN FVRCLVRLET LFKIFKQLDP ENTGTIELDL ISWLCFSVL

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta endothelial cell EMBL BAD93092.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209855 mRNA. Translation: BAD93092.1.
IPI	IPI01010797.
RefSeq	NP_001139540.1. NM_001146068.1. NP_001739.2. NM_001748.4.
UniGene	Hs.350899.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q59EF6.
Proteomic databases
PRIDE	Q59EF6.
Protocols and materials databases
DNASU	824.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	824.
KEGG	hsa:824.
Organism-specific databases
CTD	824.
PharmGKB	PA26060.
Phylogenomic databases
HOGENOM	HOG000232035.
HOVERGEN	HBG012645.
KO	K03853.
Gene expression databases
ArrayExpress	Q59EF6.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR022684. Calpain_cysteine_protease. IPR022682. Calpain_domain_III. IPR022683. Calpain_III. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR000169. Pept_cys_AS. IPR001300. Peptidase_C2_calpain_cat. [Graphical view]
Pfam	PF01067. Calpain_III. 1 hit. PF00648. Peptidase_C2. 1 hit. [Graphical view]
PRINTS	PR00704. CALPAIN.
SMART	SM00720. calpain_III. 1 hit. SM00230. CysPc. 1 hit. SM00054. EFh. 3 hits. [Graphical view]
SUPFAM	SSF49758. Peptidase_C2. 1 hit.
PROSITE	PS50203. CALPAIN_CAT. 1 hit. PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 3 hits. PS00139. THIOL_PROTEASE_CYS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	824.
NextBio	3374.

Entry information

Entry name

Q59EF6_HUMAN

Accession

Primary (citable) accession number: Q59EF6

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.