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Protein
Submitted name:

Nuclear receptor coactivator 3 isoform a variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Nuclear receptor coactivator 3 isoform a variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31472.

PTM / Processingi

Proteomic databases

PaxDbiQ59EE8.

Expressioni

Gene expression databases

GenevisibleiQ59EE8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361066.

Structurei

3D structure databases

ProteinModelPortaliQ59EE8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 8658BHLH (basic helix-loop-helix)InterPro annotationAdd
BLAST
Domaini121 – 18464PAS (PER-ARNT-SIM)InterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1249 – 127931Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 basic helix-loop-helix (bHLH) domain.UniRule annotation
Contains bHLH (basic helix-loop-helix) domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IQ5R. Eukaryota.
ENOG410ZDZC. LUCA.
HOGENOMiHOG000230947.
HOVERGENiHBG052583.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR032565. DUF4927.
IPR028818. NCOA3.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF3. PTHR10684:SF3. 1 hit.
PfamiPF07469. DUF1518. 1 hit.
PF16279. DUF4927. 1 hit.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTiSM01151. DUF1518. 1 hit.
SM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59EE8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
CIFKMSGLGE NLDPLASDSR KRKLPCDTPG QGLTCSGEKR RREQESKYIE
60 70 80 90 100
ELAELISANL SDIDNFNVKP DKCAILKETV RQIRQIKEQG KTISNDDDVQ
110 120 130 140 150
KADVSSTGQG VIDKDSLGPL LLQALDGFLF VVNRDGNIVF VSENVTQYLQ
160 170 180 190 200
YKQEDLVNTS VYNILHEEDR KDFLKNLPKS TVNGVSWTNE TQRQKSHTFN
210 220 230 240 250
CRMLMKTPHD ILEDINASPE MRQRYETMQC FALSQPRAMM EEGEDLQSCM
260 270 280 290 300
ICVARRITTG ERTFPSNPES FITRHDLSGK VVNIDTNSLR SSMRPGFEDI
310 320 330 340 350
IRRCIQRFFS LNDGQSWSQK RHYQEAYLNG HAETPVYRFS LADGTIVTAQ
360 370 380 390 400
TKSKLFRNPV TNDRHGFVST HFLQREQNGY RPNPNPVGQG IRPPMAGCNS
410 420 430 440 450
SVGGMSMSPN QGLQMPSSRA YGLADPSTTG QMSGARYGGS SNIASLTPGP
460 470 480 490 500
GMQSPSSYQN NNYGLNMSSP PHGSPGLAPN QQNIMISPRN RGSPKIASHQ
510 520 530 540 550
FSPVAGVHSP MASSGNTGNH SFSSSSLSAL QAISEGVGTS LLSTLSSPGP
560 570 580 590 600
KLDNSPNMNI TQPSKVSNQD SKSPLGFYCD QNPVESSMCQ SNSRDHLSDK
610 620 630 640 650
ESKESSVEGA ENQRGPLESK GHKKLLQLLT CSSDDRGHSS LTNSPLDSSC
660 670 680 690 700
KESSVSVTSP SGVSSSTSGG VSSTSNMHGS LLQEKHRILH KLLQNGNSPA
710 720 730 740 750
EVAKITAEAT GKDTSSITSC GDGNVVKQEQ LSPKKKENNA LLRYLLDRDD
760 770 780 790 800
PSDALSKELQ PQVEGVDNKM SQCTSSTIPS SSQEKDPKIK TETSEEGSGD
810 820 830 840 850
LDNLDAILGD LTSSDFYNNS ISSNGSHLGT KQQVFQGTNS LGLKSSQSVQ
860 870 880 890 900
SIRPPYNRAV SLDSPVSVGS SPPVKNISAF PMLPKQPMLG GNPRMMDSQE
910 920 930 940 950
NYGSSMGGPN RNVTVTQTPS SGDWGLPNSK AGRMEPMNSN SMGRPGGDYN
960 970 980 990 1000
TSLPRPALGG SIPTLPLRSN SIPGARPVLQ QQQQMLQMRP GEIPMGMGAN
1010 1020 1030 1040 1050
PYGQAAASNQ LGSWPDGMLS MEQVSHGTQN RPLLRNSLDD LVGPPSNLEG
1060 1070 1080 1090 1100
QSDERALLDQ LHTLLSNTDA TGLEEIDRAL GIPELVNQGQ ALEPKQDAFQ
1110 1120 1130 1140 1150
GQEAAVMMDQ KAGLYGQTYP AQGPPMQGGF HLQGQSPSFN SMMNQMNQQG
1160 1170 1180 1190 1200
NFPLQGMHPR ANIMRPRTNT PKQLRMQLQQ RLQGQQFLNQ SRQALELKME
1210 1220 1230 1240 1250
NPTAGGAAVM RPMMQPQVSS QGFLNAQMVA QRSRELLSHH FRQQRVAMMM
1260 1270 1280 1290 1300
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQT QAFSPPPNVT ASPSMDGLLA
1310 1320 1330 1340 1350
GPTMPQAPPQ QFPYQPNYGM GQQPDPAFGR VSSPPNAMMS SRMGPSQNPM
1360 1370 1380 1390 1400
MQHPQAASIY QSSEMKGWPS GNLARNSSFS QQQFAHQGNP AVYSMVHMNG
1410 1420
SSGHMGQMNM NPMPMSGMPM GPDQKYC
Length:1,427
Mass (Da):155,657
Last modified:April 26, 2005 - v1
Checksum:iA882D1D5ABE45ACB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209863 mRNA. Translation: BAD93100.1.
RefSeqiNP_001167558.1. NM_001174087.1.
UniGeneiHs.592142.

Genome annotation databases

GeneIDi8202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209863 mRNA. Translation: BAD93100.1.
RefSeqiNP_001167558.1. NM_001174087.1.
UniGeneiHs.592142.

3D structure databases

ProteinModelPortaliQ59EE8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361066.

Proteomic databases

PaxDbiQ59EE8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8202.

Organism-specific databases

CTDi8202.
PharmGKBiPA31472.

Phylogenomic databases

eggNOGiENOG410IQ5R. Eukaryota.
ENOG410ZDZC. LUCA.
HOGENOMiHOG000230947.
HOVERGENiHBG052583.

Miscellaneous databases

GenomeRNAii8202.

Gene expression databases

GenevisibleiQ59EE8. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
4.10.630.10. 2 hits.
InterProiIPR011598. bHLH_dom.
IPR010011. DUF1518.
IPR032565. DUF4927.
IPR028818. NCOA3.
IPR009110. Nuc_rcpt_coact.
IPR014920. Nuc_rcpt_coact_Ncoa-typ.
IPR017426. Nuclear_rcpt_coactivator.
IPR000014. PAS.
IPR013767. PAS_fold.
IPR014935. SRC-1.
IPR008955. Src1_rcpt_coact.
[Graphical view]
PANTHERiPTHR10684. PTHR10684. 1 hit.
PTHR10684:SF3. PTHR10684:SF3. 1 hit.
PfamiPF07469. DUF1518. 1 hit.
PF16279. DUF4927. 1 hit.
PF08815. Nuc_rec_co-act. 1 hit.
PF00989. PAS. 1 hit.
PF08832. SRC-1. 1 hit.
[Graphical view]
PIRSFiPIRSF038181. Nuclear_receptor_coactivator. 1 hit.
SMARTiSM01151. DUF1518. 1 hit.
SM00353. HLH. 1 hit.
SM00091. PAS. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
SSF69125. SSF69125. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Aorta endothelial cellImported.

Entry informationi

Entry nameiQ59EE8_HUMAN
AccessioniPrimary (citable) accession number: Q59EE8
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.