Q59EE4 (Q59EE4_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: DNA polymerase theta variant EMBL BAD93104.1
Organism	Homo sapiens (Human) EMBL BAD93104.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2214 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: InterPro helicase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD93104.1

Sequences

	Sequence		Length	Mass (Da)
	Q59EE4 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 327C2D6AC85F7753	FASTA	2,214	247,978
	10 20 30 40 50 60 MPTSNSGQKE LLEVMDQLRR LPSGLDSVLQ KTVPWGVAFH HAGLTFEERD IIEGAFRQGL 70 80 90 100 110 120 IRVLAATSTL SSGVNLPARR VIIRTPIFGG RPLDILTYKQ MVGRAGRKGV DTVGESILIC 130 140 150 160 170 180 KNSEKSKGIA LLQGSLKPVR SCLQRREGEE VTGSMIRAIL EIIVGGVAST SQDMHTYAAC 190 200 210 220 230 240 TFLAASMKEG KQGIQRNQES VQLGAIEACV MWLLENEFIQ STEASDGTEG KVYHPTHLGS 250 260 270 280 290 300 ATLSSSLSPA DTLDIFADLQ RAMKGFVLEN DLHILYLVTP MFEDWTTIDW YRFFCLWEKL 310 320 330 340 350 360 PTSMKRVAEL VGVEEGFLAR CVKGKVVART ERQHRQMAIH KRFFTSLVLL DLISEVPLRE 370 380 390 400 410 420 INQKYGCNRG QIQSLQQSAA VYAGMITVFS NRLGWHNMEL LLSQFQKRLT FGIQRELCDL 430 440 450 460 470 480 VRVSLLNAQR ARVLYASGFH TVADLARANI VEVEVILKNA VPFKSARKAV DEEEEAVEER 490 500 510 520 530 540 RNMRTIWVTG RKGLTEREAA ALIVEEARMI LQQDLVEMGV QWNPCALLHS STCSLTHSES 550 560 570 580 590 600 EVKEHTFISQ TKSSYKKLTS KNKSNTIFSD SYIKHSPNIV QDLNKSREHT SSFNCNFQNG 610 620 630 640 650 660 NQEHQRCSIF RARKRASLDI NKEKPGASQN EGKTSDKKVV QTFSQKTKKA PLNFNSEKMS 670 680 690 700 710 720 RSFRSWKRRK HLKRSRDSSP LKDSGACRIH LQGQTLSNPS LCEDPFTLDE KKTEFRNSGP 730 740 750 760 770 780 FAKNVSLSGK EKDNKTSFPL QIKQNCSWNI TLTNDNFVEH IVTGSQSKNV TCQATSVVSE 790 800 810 820 830 840 KGRGVAVEAE KINEVLIQNG SKNQNVYMKH HDIHPINQYL RKQSHEQTST ITKQKNIIER 850 860 870 880 890 900 QMPCEAVSSY INRDSNVTIN CERIKLNTEE NKPSHFQALG DDISRTVIPS EVLPSAGAFS 910 920 930 940 950 960 KSEGQHENFL NISRLQEKTG TYTTNKTKNN HVSDLGLVLC DFEDSFYLDT QSEKIIQQMA 970 980 990 1000 1010 1020 TENAKLGAKD TNLAAGIMQK SLVQQNSMNS FQKECHIPFP AEQHPLGATK IDHLDLKTVG 1030 1040 1050 1060 1070 1080 TMKQSSDSHG VDILTPESPI FHSPILLEEN GLFLKKNEVS VTDSQLNSFL QGYQTQETVK 1090 1100 1110 1120 1130 1140 PVILLIPQKR TPTGVEGECL PVPETSLNMS DSLLFDSFSD DYLVKEQLPD MQMKEPLPSE 1150 1160 1170 1180 1190 1200 VTSNHFSDSL CLQEDLIKKS NVNENQDTHQ QLTCSNDESI IFSEMDSVQM VEALDNVDIF 1210 1220 1230 1240 1250 1260 PVQEKNHTVV SPRALELSDP VLDEHHQGDQ DGGDQDERAE KSKLTGTRQN HSFIWSGASF 1270 1280 1290 1300 1310 1320 DLSPGLQRIL DKVSSPLENE KLKSMTINFS SLNRKNTELN EEQEVISNLE TKQVQGISFS 1330 1340 1350 1360 1370 1380 SNNEVKSKIE MLENNANHDE TSSLLPRKES NIVDDNGLIP PTPIPTSASK LTFPGILETP 1390 1400 1410 1420 1430 1440 VNPWKTNNVL QPGESYLFGS PSDIKNHDLS PGSRNGFKDN SPISDTSFSL QLSQDGLQLT 1450 1460 1470 1480 1490 1500 PASSSSESLS IIDVASDQNL FQTFIKEWRC KKRFSISLAC EKIRSLTSSK TATIGSRFKQ 1510 1520 1530 1540 1550 1560 ASSPQEIPIR DDGFPIKGCD DTLVVGLAVC WGGRDAYYFS LQKEQKHSEI SASLVPPSLD 1570 1580 1590 1600 1610 1620 PSLTLKDRMW YLQSCLRKES DKECSVVIYD FIQSYKILLL SCGISLEQSY EDPKVACWLL 1630 1640 1650 1660 1670 1680 DPDSQEPTLH SIVTSFLPHE LPLLEGMETS QGIQSLGLNA GSEHSGRYRA SVESILIFNS 1690 1700 1710 1720 1730 1740 MNQLNSLLQK ENLQDVFRKV EMPSQYCLAL LELNGIGFST AECESQKHIM QAKLDAIETQ 1750 1760 1770 1780 1790 1800 AYQLAGHSFS FTSSDDIAEV LFLELKLPPN REMKNQGSKK TLGSTRRGID NGRKLRLGRQ 1810 1820 1830 1840 1850 1860 FSTSKDVLNK LKALHPLPGL ILEWRRITNA ITKVVFPLQR EKCLNPFLGM ERIYPVSQSH 1870 1880 1890 1900 1910 1920 TATGRITFTE PNIQNVPRDF EIKMPTLVGE SPPSQAVGKG LLPMGRGKYK KGFSVNPRCQ 1930 1940 1950 1960 1970 1980 AQMEERAADR GMPFSISMRH AFVPFPGGSI LAADYSQLEL RILAHLSHDR RLIQVLNTGA 1990 2000 2010 2020 2030 2040 DVFRSIAAEW KMIEPESVGD DLRQQAKQIC YGIIYGMGAK SLGEQMGIKE NDAACYIDSF 2050 2060 2070 2080 2090 2100 KSRYTGINQF MTETVKNCKR DGFVQTILGR RRYLPGIKDN NPYRKAHAER QAINTIVQGS 2110 2120 2130 2140 2150 2160 AADIVKIATV NIQKQLETFH STFKSHGHRE GMLQSDRTGL SRKRKLQGMF CPIRGGFFIL 2170 2180 2190 2200 2210 QLHDELLYEV AEEDVVQVAQ IVKNEMESAV KLSVKLKVKV KIGASWGELK DFDV

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta endothelial cell EMBL BAD93104.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209867 mRNA. Translation: BAD93104.1.
IPI	IPI00794779.
RefSeq	NP_955452.3. NM_199420.3.
UniGene	Hs.241517.
3D structure databases
ProteinModelPortal	Q59EE4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q59EE4.
Proteomic databases
PRIDE	Q59EE4.
Protocols and materials databases
DNASU	10721.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	10721.
KEGG	hsa:10721.
Organism-specific databases
CTD	10721.
PharmGKB	PA33506.
Phylogenomic databases
HOVERGEN	HBG005525.
KO	K02349.
Gene expression databases
ArrayExpress	Q59EE4.
Family and domain databases
InterPro	IPR019760. DNA-dir_DNA_pol_A_CS. IPR001098. DNA-dir_DNA_pol_A_palm_dom. IPR002298. DNA_polymerase_A. IPR001650. Helicase_C. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF00476. DNA_pol_A. 1 hit. PF00271. Helicase_C. 1 hit. [Graphical view]
PRINTS	PR00868. DNAPOLI.
SMART	SM00490. HELICc. 1 hit. SM00482. POLAc. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
PROSITE	PS00447. DNA_POLYMERASE_A. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10721.
NextBio	40701.

Entry information

Entry name

Q59EE4_HUMAN

Accession

Primary (citable) accession number: Q59EE4

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	September 5, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.