Q59ED7 (Q59ED7_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: NADPH--cytochrome P450 reductase PIRNR PIRNR000208 EC=1.6.2.4 PIRNR PIRNR000208
Organism	Homo sapiens (Human) EMBL BAD93111.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	686 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This enzyme is required for electron transfer from NADP to cytochrome P450 By similarity. PIRNR PIRNR000208
Catalytic activity	NADPH + n oxidized hemoprotein = NADP+ + n reduced hemoprotein. PIRNR PIRNR000208
Subcellular location	Endoplasmic reticulum membrane By similarity PIRNR PIRNR000208.
Sequence similarities	In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. PIRNR PIRNR000208

Ontologies

Keywords
Cellular component	Endoplasmic reticulum PIRNR PIRNR000208 Membrane PIRNR PIRNR000208
Ligand	NADP PIRNR PIRNR000208
Molecular function	Oxidoreductase PIRNR PIRNR000208
Gene Ontology (GO)
Biological_process	carnitine metabolic process Inferred from electronic annotation. Source: Compara cellular response to follicle-stimulating hormone stimulus Inferred from electronic annotation. Source: Compara cellular response to peptide hormone stimulus Inferred from electronic annotation. Source: Compara demethylation Inferred from electronic annotation. Source: Compara fatty acid oxidation Inferred from electronic annotation. Source: Compara flavonoid metabolic process Inferred from electronic annotation. Source: Compara internal peptidyl-lysine acetylation Inferred from electronic annotation. Source: Compara negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Inferred from electronic annotation. Source: Compara negative regulation of lipase activity Inferred from electronic annotation. Source: Compara nitrate catabolic process Inferred from electronic annotation. Source: Compara nitric oxide catabolic process Inferred from electronic annotation. Source: Compara positive regulation of cholesterol biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of chondrocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of smoothened signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of steroid hormone biosynthetic process Inferred from electronic annotation. Source: Compara regulation of growth plate cartilage chondrocyte proliferation Inferred from electronic annotation. Source: Compara response to drug Inferred from electronic annotation. Source: Compara response to nutrient Inferred from electronic annotation. Source: Compara
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	FMN binding Inferred from electronic annotation. Source: Compara NADP binding Inferred from electronic annotation. Source: Compara NADPH-hemoprotein reductase activity Inferred from electronic annotation. Source: EC cytochrome-b5 reductase activity, acting on NAD(P)H Inferred from electronic annotation. Source: Compara electron carrier activity Inferred from electronic annotation. Source: Compara flavin adenine dinucleotide binding Inferred from electronic annotation. Source: Compara hydrolase activity Inferred from electronic annotation. Source: Compara iron ion binding Inferred from electronic annotation. Source: InterPro iron-cytochrome-c reductase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD93111.1

Sequences

	Sequence		Length	Mass (Da)
	Q59ED7 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 453DAD59A3F48655	FASTA	686	77,737
	10 20 30 40 50 60 PGCQRFMINM GDSHVDTSST VSEAVAEEVS LFSMTDMILF SLIVGLLTYW FLFRKKKEEV 70 80 90 100 110 120 PEFTKIQTLT SSVRESSFVE KMKKTGRNII VFYGSQTGTA EEFANRLSKD AHRYGMRGMS 130 140 150 160 170 180 ADPEEYDLAD LSSLPEIDNA LVVFCMATYG EGDPTDNAQD FYDWLQETDV DLSGVKFAVF 190 200 210 220 230 240 GLGNKTYEHF NAMGKYVDKR LEQLGAQRIF ELGLGDDDGN LEEDFITWRE QFWPAVCEHF 250 260 270 280 290 300 GVEATGEESS IRQYELVVHT DIDAAKVYMG EMGRLKSYEN QKPPFDAKNP FLAAVTTNRK 310 320 330 340 350 360 LNQGTERHLM HLELDISDSK IRYESGDHVA VYPANDSALV NQLGKILGAD LDVVMSLNNL 370 380 390 400 410 420 DEESNKKHPF PCPTSYRTAL TYYLDITNPP RTNVLYELAQ YASEPSEQEL LRKMASSSGE 430 440 450 460 470 480 GKELYLSWVV EARRHILAIL QDCPSLRPPI DHLCELLPRL QARYYSIASS SKVHPNSVHI 490 500 510 520 530 540 CAVVVEYETK AGRINKGVAT NWLRAKEPAG ENGGRALVPM FVRKSQFRLP FKATTPVIMV 550 560 570 580 590 600 GPGTGVAPFI GFIQERAWLR QQGKEVGETL LYYGCRRSDE DYLYREELAQ FHRDGALTQL 610 620 630 640 650 660 NVAFSREQSH KVYVQHLLKQ DREHLWKLIE GGAHIYVCGD ARNMARDVQN TFYDIVAELG 670 680 AMEHAQAVDY IKKLMTKGRY SLDVWS

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta endothelial cell EMBL BAD93111.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209874 mRNA. Translation: BAD93111.1.
IPI	IPI00470467.
UniGene	Hs.354056.
3D structure databases
ProteinModelPortal	Q59ED7.
ModBase	Search...
Proteomic databases
PRIDE	Q59ED7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc003udy.3. human.
Phylogenomic databases
HOGENOM	HOG000282027.
HOVERGEN	HBG000432.
Gene expression databases
ArrayExpress	Q59ED7.
Bgee	Q59ED7.
Family and domain databases
Gene3D	1.20.990.10. 1 hit.
InterPro	IPR003097. FAD-binding_1. IPR017927. Fd_Rdtase_FAD-bd. IPR001094. Flavdoxin. IPR008254. Flavodoxin/NO_synth. IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase. IPR023173. NADPH_Cyt_P450_Rdtase_dom3. IPR001433. OxRdtase_FAD/NAD-bd. IPR023208. P450R. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view]
Pfam	PF00667. FAD_binding_1. 1 hit. PF00258. Flavodoxin_1. 1 hit. PF00175. NAD_binding_1. 1 hit. [Graphical view]
PIRSF	PIRSF000208. P450R. 1 hit.
PRINTS	PR00369. FLAVODOXIN. PR00371. FPNCR.
SUPFAM	SSF63380. Riboflavin_synthase_like_b-brl. 1 hit.
PROSITE	PS51384. FAD_FR. 1 hit. PS50902. FLAVODOXIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59ED7_HUMAN

Accession

Primary (citable) accession number: Q59ED7

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	May 29, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.