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Protein
Submitted name:

Putative uncharacterized protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. cytochrome-b5 reductase activity, acting on NAD(P)H Source: Ensembl
  2. electron carrier activity Source: Ensembl
  3. flavin adenine dinucleotide binding Source: Ensembl
  4. FMN binding Source: InterPro
  5. hydrolase activity Source: Ensembl
  6. iron-cytochrome-c reductase activity Source: Ensembl
  7. iron ion binding Source: InterPro
  8. NADP binding Source: Ensembl
  9. NADPH-hemoprotein reductase activity Source: Ensembl
  10. nitric oxide dioxygenase activity Source: Ensembl

GO - Biological processi

  1. carnitine metabolic process Source: Ensembl
  2. cellular response to follicle-stimulating hormone stimulus Source: Ensembl
  3. cellular response to peptide hormone stimulus Source: Ensembl
  4. demethylation Source: Ensembl
  5. fatty acid oxidation Source: Ensembl
  6. flavonoid metabolic process Source: Ensembl
  7. internal peptidyl-lysine acetylation Source: Ensembl
  8. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  9. negative regulation of lipase activity Source: Ensembl
  10. nitrate catabolic process Source: Ensembl
  11. nitric oxide catabolic process Source: Ensembl
  12. positive regulation of cholesterol biosynthetic process Source: Ensembl
  13. positive regulation of chondrocyte differentiation Source: Ensembl
  14. positive regulation of smoothened signaling pathway Source: Ensembl
  15. positive regulation of steroid hormone biosynthetic process Source: Ensembl
  16. regulation of growth plate cartilage chondrocyte proliferation Source: Ensembl
  17. response to drug Source: Ensembl
  18. response to nutrient Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Putative uncharacterized proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: Ensembl
  2. mitochondrion Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ59ED7.

Expressioni

Gene expression databases

BgeeiQ59ED7.
ExpressionAtlasiQ59ED7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ59ED7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000282027.
HOVERGENiHBG000432.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000208. P450R. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59ED7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PGCQRFMINM GDSHVDTSST VSEAVAEEVS LFSMTDMILF SLIVGLLTYW
60 70 80 90 100
FLFRKKKEEV PEFTKIQTLT SSVRESSFVE KMKKTGRNII VFYGSQTGTA
110 120 130 140 150
EEFANRLSKD AHRYGMRGMS ADPEEYDLAD LSSLPEIDNA LVVFCMATYG
160 170 180 190 200
EGDPTDNAQD FYDWLQETDV DLSGVKFAVF GLGNKTYEHF NAMGKYVDKR
210 220 230 240 250
LEQLGAQRIF ELGLGDDDGN LEEDFITWRE QFWPAVCEHF GVEATGEESS
260 270 280 290 300
IRQYELVVHT DIDAAKVYMG EMGRLKSYEN QKPPFDAKNP FLAAVTTNRK
310 320 330 340 350
LNQGTERHLM HLELDISDSK IRYESGDHVA VYPANDSALV NQLGKILGAD
360 370 380 390 400
LDVVMSLNNL DEESNKKHPF PCPTSYRTAL TYYLDITNPP RTNVLYELAQ
410 420 430 440 450
YASEPSEQEL LRKMASSSGE GKELYLSWVV EARRHILAIL QDCPSLRPPI
460 470 480 490 500
DHLCELLPRL QARYYSIASS SKVHPNSVHI CAVVVEYETK AGRINKGVAT
510 520 530 540 550
NWLRAKEPAG ENGGRALVPM FVRKSQFRLP FKATTPVIMV GPGTGVAPFI
560 570 580 590 600
GFIQERAWLR QQGKEVGETL LYYGCRRSDE DYLYREELAQ FHRDGALTQL
610 620 630 640 650
NVAFSREQSH KVYVQHLLKQ DREHLWKLIE GGAHIYVCGD ARNMARDVQN
660 670 680
TFYDIVAELG AMEHAQAVDY IKKLMTKGRY SLDVWS
Length:686
Mass (Da):77,737
Last modified:April 25, 2005 - v1
Checksum:i453DAD59A3F48655
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209874 mRNA. Translation: BAD93111.1.
UniGeneiHs.354056.

Genome annotation databases

UCSCiuc003udy.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209874 mRNA. Translation: BAD93111.1.
UniGeneiHs.354056.

3D structure databases

ProteinModelPortaliQ59ED7.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ59ED7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc003udy.3. human.

Phylogenomic databases

HOGENOMiHOG000282027.
HOVERGENiHBG000432.

Gene expression databases

BgeeiQ59ED7.
ExpressionAtlasiQ59ED7. baseline and differential.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR023208. P450R.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PIRSFiPIRSF000208. P450R. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Aorta endothelial cellImported.

Entry informationi

Entry nameiQ59ED7_HUMAN
AccessioniPrimary (citable) accession number: Q59ED7
Entry historyi
Integrated into UniProtKB/TrEMBL: April 25, 2005
Last sequence update: April 25, 2005
Last modified: January 6, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.