Unreviewed, UniProtKB/TrEMBL Q59EB4 (Q59EB4_HUMAN)

Names and origin

Protein names	Submitted name:     LATS, large tumor suppressor, homolog 2 variant EMBL BAD93134.1
Organism	Homo sapiens (Human) EMBL BAD93134.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	924 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the protein kinase superfamily. RuleBase RU000305V3

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000304V2 Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase RuleBase RU000305V3 Transferase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD93134.1

Sequences

	Sequence		Length	Mass (Da)
	Q59EB4-1 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: 2F809DBB90B18848	FASTA	924	101,485
	10 20 30 40 50 60 KETGLTMRPK TFPATTYSGN SRQRLQEIRE GLKQPSKSSV QGLPAGPNSD TSLDAKVLGS 70 80 90 100 110 120 KDATRQQQQM RATPKFGPYQ KALREIRYSL LPFANESGTS AAAEVNRQML QELVNAGCDQ 130 140 150 160 170 180 EMAGRALKQT GSRSIEAALE YISKMGYLDP RNEQIVRVIK QTSPGKGLMP TPVTRRPSFE 190 200 210 220 230 240 GTGDSFASYH QLSGTPYEGP SFGADGPTAL EEMPRPYVDY LFPGVGPHGP GHQHQHPPKG 250 260 270 280 290 300 YGASVEAAGA HFPLQGAHYG RPHLLVPGEP LGYGVQRSPS FQSKTPPETG GYASLPTKGQ 310 320 330 340 350 360 GGPPGAGLAF PPPAAGLYVP HPHHKQAGPV AHQLHVLGSR SQVFASDSPP QSLLTPSRNS 370 380 390 400 410 420 LNVDLYELSS TSVQQWPAAT LARRDSLQKP GLEAPPRAHV AFRPDCPVPS RTNSFNSHQP 430 440 450 460 470 480 RPGPPGKAEP SLPAPNTVTA VTAAHILHPV KSVRVLRPEP QTAVGPSHPA WVPAPAPAPA 490 500 510 520 530 540 PAPAPAAEGL DAKEEHALAL GGAGAFPLDV EYGGPDRRCP PPPYPKHLLL RSKSEQYDLD 550 560 570 580 590 600 SLCAGMEQSL RAGPNEPEGG DKSRKSAKGD KGGKDKKQIQ TSPVPVRKNS RDEEKRESRI 610 620 630 640 650 660 KSYSPYAFKF FMEQHVENVI KTYQQKVNRR LQLEQEMAKA GLCEAEQEQM RKILYQKESN 670 680 690 700 710 720 YNRLKRAKMD KSMFVKIKTL GIGAFGEVCL ACKVDTHALY AMKTLRKKDV LNRNQVAHVK 730 740 750 760 770 780 AERDILAEAD NEWVVKLYYS FQDKDSLYFV MDYIPGGDMM SLLIRMEVFP EHLARFYIAE 790 800 810 820 830 840 LTLAIESVHK MGFIHRDIKP DNILIDLDGH IKLTDFGLCT GFRWTHNSKY YQKGSHVRQD 850 860 870 880 890 900 SMEPSDLWDD VSNCRCGDRL KTLEQRARKQ HQRCLAHSLV GTPNYIAPEV LLRKGTCAMA 910 920 SHPAGGLLPF RRELSLAGSS FPRT

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta endothelial cell EMBL BAD93134.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB209897 mRNA. Translation: BAD93134.1.
UniGene	Hs.78960
3D structure databases
SMR	Q59EB4. Positions 98-145.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000150457. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:6515. LATS2.
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q59EB4.
Gene expression databases
ArrayExpress	Q59EB4.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR000449. UBA/transl_elong_EF1B_N. IPR015940. UBA/transl_elong_EF1B_N_euk. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. PF00627. UBA. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 2 hits. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50030. UBA. 1 hit. [Graphical view]

Entry information

Entry name

Q59EB4_HUMAN

Accession

Primary (citable) accession number: Q59EB4

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	July 22, 2008
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)