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Protein
Submitted name:

Phospholipase D1 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Phospholipase D1 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  • lysosomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164742228.

PTM / Processingi

Proteomic databases

PaxDbiQ59EA4.
PRIDEiQ59EA4.

Expressioni

Gene expression databases

BgeeiQ59EA4.
GenevisibleiQ59EA4. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342793.

Structurei

3D structure databases

ProteinModelPortaliQ59EA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 235132PX (phox homology)InterPro annotationAdd
BLAST
Domaini482 – 50928PLD phosphodiesteraseInterPro annotationAdd
BLAST
Domaini876 – 90328PLD phosphodiesteraseInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG1329. Eukaryota.
COG1502. LUCA.
HOGENOMiHOG000246972.
HOVERGENiHBG006650.
KOiK01115.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001683. Phox.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
IPR016555. PLipase_D1/D2.
IPR015679. PLipase_D_fam.
[Graphical view]
PANTHERiPTHR18896. PTHR18896. 2 hits.
PfamiPF00169. PH. 1 hit.
PF00614. PLDc. 1 hit.
PF13091. PLDc_2. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
PIRSFiPIRSF009376. Phospholipase_D_euk. 1 hit.
SMARTiSM00233. PH. 1 hit.
SM00155. PLDc. 2 hits.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
PS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59EA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ANAQVLAAPS PCSPFAFTLS KVNMSLKNEP RVNTSALQKI AADMSNIIEN
60 70 80 90 100
LDTRELHFEG EEVDYDVSPS DPKIQEVYIP FSAIYNTQGF KEPNIQTYLS
110 120 130 140 150
GCPIKAQVLE VERFTSTTRV PSINLYTIEL THGEFKWQVK RKFKHFQEFH
160 170 180 190 200
RELLKYKAFI RIPIPTRRHT FRRQNVREEP REMPSLPRSS ENMIREEQFL
210 220 230 240 250
GRRKQLEDYL TKILKMPMYR NYHATTEFLD ISQLSFIHDL GPKGIEGMIM
260 270 280 290 300
KRSGGHRIPG LNCCGQGRAC YRWSKRWLIV KDSFLLYMKP DSGAIAFVLL
310 320 330 340 350
VDKEFKIKVG KKETETKYGI RIDNLSRTLI LKCNSYRHAR WWGGAIEEFI
360 370 380 390 400
QKHGTNFLKD HRFGSYAAIQ ENALAKWYVN AKGYFEDVAN AMEEANEEIF
410 420 430 440 450
ITDWWLSPEI FLKRPVVEGN RWRLDCILKR KAQQGVRIFI MLYKEVELAL
460 470 480 490 500
GINSEYTKRT LMRLHPNIKV MRHPDHVSST VYLWAHHEKL VIIDQSVAFV
510 520 530 540 550
GGIDLAYGRW DDNEHRLTDV GSVKRVTSGP SLGSLPPAAM ESMESLRLKD
560 570 580 590 600
KNEPVQNLPI QKSIDDVDSK LKGIGKPRKF SKFSLYKQLH RHHLHDADSI
610 620 630 640 650
SSIDSTSNTG SIRSLQTGVG ELHGETRFWH GKDYCNFVFK DWVQLDKPFA
660 670 680 690 700
DFIDRYSTPR MPWHDIASAV HGKAARDVAR HFIQRWNFTK IMKSKYRSLS
710 720 730 740 750
YPFLLPKSQT TAHELRYQVP GSVHANVQLL RSAADWSAGI KYHEESIHAA
760 770 780 790 800
YVHVIENSRH YIYIENQFFI SCADDKVVFN KIGDAIAQRI LKAHRENQKY
810 820 830 840 850
RVYVVIPLLP GFEGDISTGG GNALQAIMHF NYRTMCRGEN SILGQLKAEL
860 870 880 890 900
GNQWINYISF CGLRTHAELE GNLVTELIYV HSKLLIADDN TVIIGSANIN
910 920 930 940 950
DRSMLGKRDS EMAVIVQDTE TVPSVMDGKE YQAGRFARGL RLQCFRVVLG
960 970 980 990 1000
YLDDPSEDIQ DPVSDKFFKE VWVSTAARNA TIYDKVFRCL PNDEVHNLIQ
1010 1020 1030 1040 1050
LRDFINKPVL AKEDPIRAEE ELKKIRGFLV QFPFYFLSEE SLLPSVGTKE

AIVPMEVWT
Length:1,059
Mass (Da):122,009
Last modified:April 26, 2005 - v1
Checksum:iBC5A4072C54AC053
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209907 mRNA. Translation: BAD93144.1.
RefSeqiNP_001123553.1. NM_001130081.2.
NP_002653.1. NM_002662.4.
UniGeneiHs.382865.
Hs.732969.

Genome annotation databases

GeneIDi5337.
KEGGihsa:5337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209907 mRNA. Translation: BAD93144.1.
RefSeqiNP_001123553.1. NM_001130081.2.
NP_002653.1. NM_002662.4.
UniGeneiHs.382865.
Hs.732969.

3D structure databases

ProteinModelPortaliQ59EA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342793.

Proteomic databases

PaxDbiQ59EA4.
PRIDEiQ59EA4.

Protocols and materials databases

DNASUi5337.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5337.
KEGGihsa:5337.

Organism-specific databases

CTDi5337.
PharmGKBiPA164742228.

Phylogenomic databases

eggNOGiKOG1329. Eukaryota.
COG1502. LUCA.
HOGENOMiHOG000246972.
HOVERGENiHBG006650.
KOiK01115.

Miscellaneous databases

GenomeRNAii5337.
NextBioi20672.

Gene expression databases

BgeeiQ59EA4.
GenevisibleiQ59EA4. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
3.30.1520.10. 1 hit.
InterProiIPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR001683. Phox.
IPR025202. PLD-like_dom.
IPR001736. PLipase_D/transphosphatidylase.
IPR016555. PLipase_D1/D2.
IPR015679. PLipase_D_fam.
[Graphical view]
PANTHERiPTHR18896. PTHR18896. 2 hits.
PfamiPF00169. PH. 1 hit.
PF00614. PLDc. 1 hit.
PF13091. PLDc_2. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
PIRSFiPIRSF009376. Phospholipase_D_euk. 1 hit.
SMARTiSM00233. PH. 1 hit.
SM00155. PLDc. 2 hits.
SM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50035. PLD. 2 hits.
PS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Aorta endothelial cellImported.

Entry informationi

Entry nameiQ59EA4_HUMAN
AccessioniPrimary (citable) accession number: Q59EA4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 16, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.