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Protein

DNA-directed RNA polymerase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.6UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationImported

PTM / Processingi

Proteomic databases

PRIDEiQ59E91.

Interactioni

Protein-protein interaction databases

IntActiQ59E91. 1 interaction.
STRINGi9606.ENSP00000215591.

Family & Domainsi

Sequence similaritiesi

Belongs to the phage and mitochondrial RNA polymerase family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG078730.

Family and domain databases

Gene3Di1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR029262. RPOL_N.
[Graphical view]
PANTHERiPTHR10102. PTHR10102. 1 hit.
PfamiPF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view]
PROSITEiPS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59E91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
RLQVEPRLLS KQMAGCLEDC TRQAPESPWE EQLARLLQEA PGKLSLDVEQ
60 70 80 90 100
APSGQHSQAQ LSGQQQRLLA FFKCCLLTDQ LPLAHHLLVV HHGQRQKRKL
110 120 130 140 150
LTLDMYNAVM LGWARQGAFK ELVYVLFMVK DAGLTPDLLS YAAALQCMGR
160 170 180 190 200
QDQDAGTIER CLEQMSQEGL KLQALFTAVL LSEEDRATVL KAVHKVKPTF
210 220 230 240 250
SLPPQLPPPV NTSKLLRDVY AKDGRVSYPK LHLPLKTLQC LFEKQLHMEL
260 270 280 290 300
ASRVCVVSVE KPTLPSKEVK HARKTLKTLR DQWEKALCRA LRETKNRLER
310 320 330 340 350
EVYEGRFSLY PFLCLLDERE VVRMLLQVLQ ALPAQGESFT TLARELSART
360 370 380 390 400
FSRHVVQRQR VSGQVQALQN HYRKYLCLLA SDAEVPEPCL PRQYWEALGA
410 420 430 440 450
PEALREQPWP LPVQMELGKL LAEMLVQATQ MPCSLDKPHR SSRLVPVLYH
460 470 480 490 500
VYSFRNVQQI GILKPHPAYV QLLEKAAEPT LTFEAVDVPM LCPPLPWTSP
510 520 530 540 550
HSGAFLLSPT KLMRTVEGAT QHQELLETCP PTALHGALDA LTQLGNCAWR
560 570 580 590 600
VNGRVLDLVL QLFQAKGCPQ LGVPAPPSEA PQPPEAHLPH SAAPARKAEL
610 620 630 640 650
RRELAHCQKV AREMHSLRAE ALYRLSLAQH LRDRVFWLPH NMDFRGRTYP
660 670 680 690 700
CPPHFNHLGS DVARALLEFA QGRPLGPHGL DWLKIHLVNL TGLKKREPLR
710 720 730 740 750
KRLAFAEEVM DDILDSADQP LTGRKWWMGA EEPWQTLACC MEVANAVRAS
760 770 780 790 800
DPAAYVSHLP VHQDGSCNGL QHYAALGRDS VGAASVNLEP SDVPQDVYSG
810 820 830 840 850
VAAQVEVFRR QDAQRGMRVA QVLEGFITRK VVKQTVMTVV YGVTRYGGRL
860 870 880 890 900
QIEKRLRELS DFPQEFVWEA SHYLVRQVFK SLQEMFSGTR AIQHWLTESA
910 920 930 940 950
RLISHMGSVV EWVTPLGVPV IQPYRLDSKV KQIGGGIQSI TYTHNGDISR
960 970 980 990 1000
KPNTRKQKNG FPPNFIHSLD SSHMMLTALH CYRKGLTFVS VHDCYWTHAA
1010 1020 1030 1040 1050
DVSVMNQVCR EQFVRLHSEP ILQDLSRFLV KRFCSEPQKI LEASQLKETL
1060 1070
QAVPKPGAFD LEQVKRSTYF FS
Length:1,072
Mass (Da):121,236
Last modified:April 26, 2005 - v1
Checksum:iF49CB7C2556170B6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209920 mRNA. Translation: BAD93157.1.
UniGeneiHs.254113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209920 mRNA. Translation: BAD93157.1.
UniGeneiHs.254113.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ59E91. 1 interaction.
STRINGi9606.ENSP00000215591.

Proteomic databases

PRIDEiQ59E91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG078730.

Family and domain databases

Gene3Di1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR029262. RPOL_N.
[Graphical view]
PANTHERiPTHR10102. PTHR10102. 1 hit.
PfamiPF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view]
PROSITEiPS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Aorta endothelial cellImported.

Entry informationi

Entry nameiQ59E91_HUMAN
AccessioniPrimary (citable) accession number: Q59E91
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 24, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.