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Q59E91

- Q59E91_HUMAN

UniProt

Q59E91 - Q59E91_HUMAN

Protein

DNA-directed RNA polymerase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (26 Apr 2005)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Keywords - Molecular functioni

    NucleotidyltransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Transcription

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.6UniRule annotation)
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotationImported

    PTM / Processingi

    Proteomic databases

    PRIDEiQ59E91.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the phage and mitochondrial RNA polymerase family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG078730.

    Family and domain databases

    Gene3Di1.10.1320.10. 1 hit.
    1.10.287.260. 1 hit.
    InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
    IPR002092. DNA-dir_Rpol_phage-type.
    IPR029262. RPOL_N.
    [Graphical view]
    PANTHERiPTHR10102. PTHR10102. 1 hit.
    PfamiPF00940. RNA_pol. 1 hit.
    PF14700. RPOL_N. 1 hit.
    [Graphical view]
    PROSITEiPS00900. RNA_POL_PHAGE_1. 1 hit.
    PS00489. RNA_POL_PHAGE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q59E91-1 [UniParc]FASTAAdd to Basket

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    RLQVEPRLLS KQMAGCLEDC TRQAPESPWE EQLARLLQEA PGKLSLDVEQ     50
    APSGQHSQAQ LSGQQQRLLA FFKCCLLTDQ LPLAHHLLVV HHGQRQKRKL 100
    LTLDMYNAVM LGWARQGAFK ELVYVLFMVK DAGLTPDLLS YAAALQCMGR 150
    QDQDAGTIER CLEQMSQEGL KLQALFTAVL LSEEDRATVL KAVHKVKPTF 200
    SLPPQLPPPV NTSKLLRDVY AKDGRVSYPK LHLPLKTLQC LFEKQLHMEL 250
    ASRVCVVSVE KPTLPSKEVK HARKTLKTLR DQWEKALCRA LRETKNRLER 300
    EVYEGRFSLY PFLCLLDERE VVRMLLQVLQ ALPAQGESFT TLARELSART 350
    FSRHVVQRQR VSGQVQALQN HYRKYLCLLA SDAEVPEPCL PRQYWEALGA 400
    PEALREQPWP LPVQMELGKL LAEMLVQATQ MPCSLDKPHR SSRLVPVLYH 450
    VYSFRNVQQI GILKPHPAYV QLLEKAAEPT LTFEAVDVPM LCPPLPWTSP 500
    HSGAFLLSPT KLMRTVEGAT QHQELLETCP PTALHGALDA LTQLGNCAWR 550
    VNGRVLDLVL QLFQAKGCPQ LGVPAPPSEA PQPPEAHLPH SAAPARKAEL 600
    RRELAHCQKV AREMHSLRAE ALYRLSLAQH LRDRVFWLPH NMDFRGRTYP 650
    CPPHFNHLGS DVARALLEFA QGRPLGPHGL DWLKIHLVNL TGLKKREPLR 700
    KRLAFAEEVM DDILDSADQP LTGRKWWMGA EEPWQTLACC MEVANAVRAS 750
    DPAAYVSHLP VHQDGSCNGL QHYAALGRDS VGAASVNLEP SDVPQDVYSG 800
    VAAQVEVFRR QDAQRGMRVA QVLEGFITRK VVKQTVMTVV YGVTRYGGRL 850
    QIEKRLRELS DFPQEFVWEA SHYLVRQVFK SLQEMFSGTR AIQHWLTESA 900
    RLISHMGSVV EWVTPLGVPV IQPYRLDSKV KQIGGGIQSI TYTHNGDISR 950
    KPNTRKQKNG FPPNFIHSLD SSHMMLTALH CYRKGLTFVS VHDCYWTHAA 1000
    DVSVMNQVCR EQFVRLHSEP ILQDLSRFLV KRFCSEPQKI LEASQLKETL 1050
    QAVPKPGAFD LEQVKRSTYF FS 1072
    Length:1,072
    Mass (Da):121,236
    Last modified:April 26, 2005 - v1
    Checksum:iF49CB7C2556170B6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209920 mRNA. Translation: BAD93157.1.
    UniGeneiHs.254113.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209920 mRNA. Translation: BAD93157.1 .
    UniGenei Hs.254113.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q59E91.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG078730.

    Family and domain databases

    Gene3Di 1.10.1320.10. 1 hit.
    1.10.287.260. 1 hit.
    InterProi IPR024075. DNA-dir_RNA_pol_helix_hairpin.
    IPR002092. DNA-dir_Rpol_phage-type.
    IPR029262. RPOL_N.
    [Graphical view ]
    PANTHERi PTHR10102. PTHR10102. 1 hit.
    Pfami PF00940. RNA_pol. 1 hit.
    PF14700. RPOL_N. 1 hit.
    [Graphical view ]
    PROSITEi PS00900. RNA_POL_PHAGE_1. 1 hit.
    PS00489. RNA_POL_PHAGE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Aorta endothelial cellImported.

    Entry informationi

    Entry nameiQ59E91_HUMAN
    AccessioniPrimary (citable) accession number: Q59E91
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.