Q59E91 (Q59E91_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Recommended name: DNA-directed RNA polymerase RuleBase RU003805 EC=2.7.7.6 RuleBase RU003805
Organism	Homo sapiens (Human) EMBL BAD93157.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1072 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity. RuleBase RU003805
Catalytic activity	Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). RuleBase RU003805
Sequence similarities	Belongs to the phage and mitochondrial RNA polymerase family. RuleBase RU003805

Ontologies

Keywords
Biological process	Transcription
Cellular component	DNA-directed RNA polymerase RuleBase RU003805 EMBL BAD93157.1
Molecular function	Nucleotidyltransferase RuleBase RU003805 Transferase
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed RNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL BAD93157.1

Sequences

	Sequence		Length	Mass (Da)
	Q59E91 [UniParc]. Last modified April 26, 2005. Version 1. Checksum: F49CB7C2556170B6	FASTA	1,072	121,236
	10 20 30 40 50 60 RLQVEPRLLS KQMAGCLEDC TRQAPESPWE EQLARLLQEA PGKLSLDVEQ APSGQHSQAQ 70 80 90 100 110 120 LSGQQQRLLA FFKCCLLTDQ LPLAHHLLVV HHGQRQKRKL LTLDMYNAVM LGWARQGAFK 130 140 150 160 170 180 ELVYVLFMVK DAGLTPDLLS YAAALQCMGR QDQDAGTIER CLEQMSQEGL KLQALFTAVL 190 200 210 220 230 240 LSEEDRATVL KAVHKVKPTF SLPPQLPPPV NTSKLLRDVY AKDGRVSYPK LHLPLKTLQC 250 260 270 280 290 300 LFEKQLHMEL ASRVCVVSVE KPTLPSKEVK HARKTLKTLR DQWEKALCRA LRETKNRLER 310 320 330 340 350 360 EVYEGRFSLY PFLCLLDERE VVRMLLQVLQ ALPAQGESFT TLARELSART FSRHVVQRQR 370 380 390 400 410 420 VSGQVQALQN HYRKYLCLLA SDAEVPEPCL PRQYWEALGA PEALREQPWP LPVQMELGKL 430 440 450 460 470 480 LAEMLVQATQ MPCSLDKPHR SSRLVPVLYH VYSFRNVQQI GILKPHPAYV QLLEKAAEPT 490 500 510 520 530 540 LTFEAVDVPM LCPPLPWTSP HSGAFLLSPT KLMRTVEGAT QHQELLETCP PTALHGALDA 550 560 570 580 590 600 LTQLGNCAWR VNGRVLDLVL QLFQAKGCPQ LGVPAPPSEA PQPPEAHLPH SAAPARKAEL 610 620 630 640 650 660 RRELAHCQKV AREMHSLRAE ALYRLSLAQH LRDRVFWLPH NMDFRGRTYP CPPHFNHLGS 670 680 690 700 710 720 DVARALLEFA QGRPLGPHGL DWLKIHLVNL TGLKKREPLR KRLAFAEEVM DDILDSADQP 730 740 750 760 770 780 LTGRKWWMGA EEPWQTLACC MEVANAVRAS DPAAYVSHLP VHQDGSCNGL QHYAALGRDS 790 800 810 820 830 840 VGAASVNLEP SDVPQDVYSG VAAQVEVFRR QDAQRGMRVA QVLEGFITRK VVKQTVMTVV 850 860 870 880 890 900 YGVTRYGGRL QIEKRLRELS DFPQEFVWEA SHYLVRQVFK SLQEMFSGTR AIQHWLTESA 910 920 930 940 950 960 RLISHMGSVV EWVTPLGVPV IQPYRLDSKV KQIGGGIQSI TYTHNGDISR KPNTRKQKNG 970 980 990 1000 1010 1020 FPPNFIHSLD SSHMMLTALH CYRKGLTFVS VHDCYWTHAA DVSVMNQVCR EQFVRLHSEP 1030 1040 1050 1060 1070 ILQDLSRFLV KRFCSEPQKI LEASQLKETL QAVPKPGAFD LEQVKRSTYF FS

References

[1]	"Homo sapiens protein coding cDNA." Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Aorta endothelial cell EMBL BAD93157.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB209920 mRNA. Translation: BAD93157.1.
IPI	IPI00298738.
UniGene	Hs.254113.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q59E91.
Proteomic databases
PRIDE	Q59E91.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG078730.
Gene expression databases
ArrayExpress	Q59E91.
Family and domain databases
Gene3D	1.10.287.260. 1 hit.
InterPro	IPR024075. DNA-dir_RNA_pol_helix_hairpin. IPR002092. DNA-dir_Rpol_phage-type. [Graphical view]
PANTHER	PTHR10102. PTHR10102. 1 hit.
Pfam	PF00940. RNA_pol. 1 hit. [Graphical view]
PROSITE	PS00900. RNA_POL_PHAGE_1. 1 hit. PS00489. RNA_POL_PHAGE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q59E91_HUMAN

Accession

Primary (citable) accession number: Q59E91

Entry history

Integrated into UniProtKB/TrEMBL:	April 26, 2005
Last sequence update:	April 26, 2005
Last modified:	March 6, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.