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Protein

DNA-directed RNA polymerase

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.6UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymeraseUniRule annotationImported

    PTM / Processingi

    Proteomic databases

    PeptideAtlasiQ59E91
    PRIDEiQ59E91

    Interactioni

    Protein-protein interaction databases

    IntActiQ59E91, 1 interactor

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini243 – 546RPOL_NInterPro annotationAdd BLAST304

    Sequence similaritiesi

    Belongs to the phage and mitochondrial RNA polymerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiKOG1038 Eukaryota
    COG5108 LUCA
    HOVERGENiHBG078730

    Family and domain databases

    Gene3Di1.10.1320.10, 1 hit
    1.25.40.10, 1 hit
    InterProiView protein in InterPro
    IPR002092 DNA-dir_Rpol_phage-type
    IPR037159 RNA_POL_N_sf
    IPR029262 RPOL_N
    IPR011990 TPR-like_helical_dom_sf
    PANTHERiPTHR10102 PTHR10102, 1 hit
    PfamiView protein in Pfam
    PF00940 RNA_pol, 1 hit
    PF14700 RPOL_N, 1 hit
    SMARTiView protein in SMART
    SM01311 RPOL_N, 1 hit
    PROSITEiView protein in PROSITE
    PS00900 RNA_POL_PHAGE_1, 1 hit
    PS00489 RNA_POL_PHAGE_2, 1 hit

    Sequencei

    Sequence statusi: Fragment.

    Q59E91-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    RLQVEPRLLS KQMAGCLEDC TRQAPESPWE EQLARLLQEA PGKLSLDVEQ
    60 70 80 90 100
    APSGQHSQAQ LSGQQQRLLA FFKCCLLTDQ LPLAHHLLVV HHGQRQKRKL
    110 120 130 140 150
    LTLDMYNAVM LGWARQGAFK ELVYVLFMVK DAGLTPDLLS YAAALQCMGR
    160 170 180 190 200
    QDQDAGTIER CLEQMSQEGL KLQALFTAVL LSEEDRATVL KAVHKVKPTF
    210 220 230 240 250
    SLPPQLPPPV NTSKLLRDVY AKDGRVSYPK LHLPLKTLQC LFEKQLHMEL
    260 270 280 290 300
    ASRVCVVSVE KPTLPSKEVK HARKTLKTLR DQWEKALCRA LRETKNRLER
    310 320 330 340 350
    EVYEGRFSLY PFLCLLDERE VVRMLLQVLQ ALPAQGESFT TLARELSART
    360 370 380 390 400
    FSRHVVQRQR VSGQVQALQN HYRKYLCLLA SDAEVPEPCL PRQYWEALGA
    410 420 430 440 450
    PEALREQPWP LPVQMELGKL LAEMLVQATQ MPCSLDKPHR SSRLVPVLYH
    460 470 480 490 500
    VYSFRNVQQI GILKPHPAYV QLLEKAAEPT LTFEAVDVPM LCPPLPWTSP
    510 520 530 540 550
    HSGAFLLSPT KLMRTVEGAT QHQELLETCP PTALHGALDA LTQLGNCAWR
    560 570 580 590 600
    VNGRVLDLVL QLFQAKGCPQ LGVPAPPSEA PQPPEAHLPH SAAPARKAEL
    610 620 630 640 650
    RRELAHCQKV AREMHSLRAE ALYRLSLAQH LRDRVFWLPH NMDFRGRTYP
    660 670 680 690 700
    CPPHFNHLGS DVARALLEFA QGRPLGPHGL DWLKIHLVNL TGLKKREPLR
    710 720 730 740 750
    KRLAFAEEVM DDILDSADQP LTGRKWWMGA EEPWQTLACC MEVANAVRAS
    760 770 780 790 800
    DPAAYVSHLP VHQDGSCNGL QHYAALGRDS VGAASVNLEP SDVPQDVYSG
    810 820 830 840 850
    VAAQVEVFRR QDAQRGMRVA QVLEGFITRK VVKQTVMTVV YGVTRYGGRL
    860 870 880 890 900
    QIEKRLRELS DFPQEFVWEA SHYLVRQVFK SLQEMFSGTR AIQHWLTESA
    910 920 930 940 950
    RLISHMGSVV EWVTPLGVPV IQPYRLDSKV KQIGGGIQSI TYTHNGDISR
    960 970 980 990 1000
    KPNTRKQKNG FPPNFIHSLD SSHMMLTALH CYRKGLTFVS VHDCYWTHAA
    1010 1020 1030 1040 1050
    DVSVMNQVCR EQFVRLHSEP ILQDLSRFLV KRFCSEPQKI LEASQLKETL
    1060 1070
    QAVPKPGAFD LEQVKRSTYF FS
    Length:1,072
    Mass (Da):121,236
    Last modified:April 26, 2005 - v1
    Checksum:iF49CB7C2556170B6
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Non-terminal residuei1Imported1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB209920 mRNA Translation: BAD93157.1
    UniGeneiHs.254113

    Similar proteinsi

    Entry informationi

    Entry nameiQ59E91_HUMAN
    AccessioniPrimary (citable) accession number: Q59E91
    Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: April 26, 2005
    Last modified: May 23, 2018
    This is version 69 of the entry and version 1 of the sequence. See complete history.
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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