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Q59E91

- Q59E91_HUMAN

UniProt

Q59E91 - Q59E91_HUMAN

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Protein
DNA-directed RNA polymerase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. transcription, DNA-templated Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymeraseUniRule annotation (EC:2.7.7.6UniRule annotation)
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotationImported

PTM / Processingi

Proteomic databases

PRIDEiQ59E91.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG078730.

Family and domain databases

Gene3Di1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProiIPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR029262. RPOL_N.
[Graphical view]
PANTHERiPTHR10102. PTHR10102. 1 hit.
PfamiPF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view]
PROSITEiPS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59E91-1 [UniParc]FASTAAdd to Basket

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RLQVEPRLLS KQMAGCLEDC TRQAPESPWE EQLARLLQEA PGKLSLDVEQ     50
APSGQHSQAQ LSGQQQRLLA FFKCCLLTDQ LPLAHHLLVV HHGQRQKRKL 100
LTLDMYNAVM LGWARQGAFK ELVYVLFMVK DAGLTPDLLS YAAALQCMGR 150
QDQDAGTIER CLEQMSQEGL KLQALFTAVL LSEEDRATVL KAVHKVKPTF 200
SLPPQLPPPV NTSKLLRDVY AKDGRVSYPK LHLPLKTLQC LFEKQLHMEL 250
ASRVCVVSVE KPTLPSKEVK HARKTLKTLR DQWEKALCRA LRETKNRLER 300
EVYEGRFSLY PFLCLLDERE VVRMLLQVLQ ALPAQGESFT TLARELSART 350
FSRHVVQRQR VSGQVQALQN HYRKYLCLLA SDAEVPEPCL PRQYWEALGA 400
PEALREQPWP LPVQMELGKL LAEMLVQATQ MPCSLDKPHR SSRLVPVLYH 450
VYSFRNVQQI GILKPHPAYV QLLEKAAEPT LTFEAVDVPM LCPPLPWTSP 500
HSGAFLLSPT KLMRTVEGAT QHQELLETCP PTALHGALDA LTQLGNCAWR 550
VNGRVLDLVL QLFQAKGCPQ LGVPAPPSEA PQPPEAHLPH SAAPARKAEL 600
RRELAHCQKV AREMHSLRAE ALYRLSLAQH LRDRVFWLPH NMDFRGRTYP 650
CPPHFNHLGS DVARALLEFA QGRPLGPHGL DWLKIHLVNL TGLKKREPLR 700
KRLAFAEEVM DDILDSADQP LTGRKWWMGA EEPWQTLACC MEVANAVRAS 750
DPAAYVSHLP VHQDGSCNGL QHYAALGRDS VGAASVNLEP SDVPQDVYSG 800
VAAQVEVFRR QDAQRGMRVA QVLEGFITRK VVKQTVMTVV YGVTRYGGRL 850
QIEKRLRELS DFPQEFVWEA SHYLVRQVFK SLQEMFSGTR AIQHWLTESA 900
RLISHMGSVV EWVTPLGVPV IQPYRLDSKV KQIGGGIQSI TYTHNGDISR 950
KPNTRKQKNG FPPNFIHSLD SSHMMLTALH CYRKGLTFVS VHDCYWTHAA 1000
DVSVMNQVCR EQFVRLHSEP ILQDLSRFLV KRFCSEPQKI LEASQLKETL 1050
QAVPKPGAFD LEQVKRSTYF FS 1072
Length:1,072
Mass (Da):121,236
Last modified:April 26, 2005 - v1
Checksum:iF49CB7C2556170B6
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209920 mRNA. Translation: BAD93157.1.
UniGeneiHs.254113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB209920 mRNA. Translation: BAD93157.1 .
UniGenei Hs.254113.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q59E91.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG078730.

Family and domain databases

Gene3Di 1.10.1320.10. 1 hit.
1.10.287.260. 1 hit.
InterProi IPR024075. DNA-dir_RNA_pol_helix_hairpin.
IPR002092. DNA-dir_Rpol_phage-type.
IPR029262. RPOL_N.
[Graphical view ]
PANTHERi PTHR10102. PTHR10102. 1 hit.
Pfami PF00940. RNA_pol. 1 hit.
PF14700. RPOL_N. 1 hit.
[Graphical view ]
PROSITEi PS00900. RNA_POL_PHAGE_1. 1 hit.
PS00489. RNA_POL_PHAGE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Aorta endothelial cellImported.

Entry informationi

Entry nameiQ59E91_HUMAN
AccessioniPrimary (citable) accession number: Q59E91
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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