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Q59E88

- Q59E88_HUMAN

UniProt

Q59E88 - Q59E88_HUMAN

Protein
Submitted name:

DnaJ (Hsp40) homolog, subfamily A, member 3 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. metal ion binding Source: UniProtKB-KW
    3. small GTPase regulator activity Source: Ensembl

    GO - Biological processi

    1. activation-induced cell death of T cells Source: Ensembl
    2. cell aging Source: Ensembl
    3. embryo development Source: Ensembl
    4. mitochondrial DNA replication Source: Ensembl
    5. positive regulation of T cell proliferation Source: Ensembl
    6. protein folding Source: InterPro
    7. response to heat Source: InterPro
    8. skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
    9. small GTPase mediated signal transduction Source: Ensembl
    10. T cell differentiation in thymus Source: Ensembl

    Keywords - Molecular functioni

    ChaperoneUniRule annotation

    Keywords - Ligandi

    Metal-bindingUniRule annotation, ZincUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    DnaJ (Hsp40) homolog, subfamily A, member 3 variantImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. extrinsic component of plasma membrane Source: Ensembl
    3. intracellular membrane-bounded organelle Source: HPA
    4. mitochondrion Source: HPA
    5. neuromuscular junction Source: Ensembl
    6. nucleus Source: Ensembl
    7. postsynaptic membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiQ59E88.

    Expressioni

    Gene expression databases

    ArrayExpressiQ59E88.
    BgeeiQ59E88.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59E88.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    RepeatUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG051371.
    KOiK09504.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    2.10.230.10. 1 hit.
    HAMAPiMF_01152. DnaJ.
    InterProiIPR012724. DnaJ.
    IPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    IPR001305. HSP_DnaJ_Cys-rich_dom.
    [Graphical view]
    PfamiPF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    PF00684. DnaJ_CXXCXGXG. 1 hit.
    [Graphical view]
    PRINTSiPR00625. JDOMAIN.
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 1 hit.
    SSF57938. SSF57938. 1 hit.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    PS51188. ZF_CR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q59E88-1 [UniParc]FASTAAdd to Basket

    « Hide

    ARCSTRWLLV VVGTPRLPAI SGRGARPPRE GVVGAWLSRK LSVPAFASSL    50
    TSCGPRALLT LRPGVSLTGT KHNPFICTAS FHTSAPLAKE DYYQILGVPR 100
    NASQKEIKKA YYQLAKKYHP DTNKDDPKAK EKFSQLAEAY EVLSDEVKRK 150
    QYDAYGSAGF DPGASGSQHS YWKGGPTVDP EELFRKIFGE FSSSSFGDFQ 200
    TVFDQPQEYF MELTFNQAAK GVNKEFTVNI MDTCERCNGK GNEPGTKVQH 250
    CHYCGGSGME TINTGPFVMR STCRRCGGRG SIIISPCVVC RGAGQAKQKK 300
    RVMIPVPAGV EDGQTVRMPV GKREIFITFR VQKSPVFRRD GADIHSDLFI 350
    SIAQALLGGT ARAQGLYETI NVTIPPGTQT DQKIRMGGKG IPRINSYGYG 400
    DHYIHIKIRV PKRLTSRQQS LILSYAEDET DVEGTVNGVT LTSSGGSTMD 450
    SSAGSKARRE AGEDEEGFLS KLKKMFTS 478
    Length:478
    Mass (Da):52,286
    Last modified:May 10, 2005 - v1
    Checksum:iF79D9A5FC3B18DD9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209923 mRNA. Translation: BAD93160.1.
    RefSeqiNP_005138.3. NM_005147.5.
    UniGeneiHs.459779.

    Genome annotation databases

    GeneIDi9093.
    KEGGihsa:9093.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB209923 mRNA. Translation: BAD93160.1 .
    RefSeqi NP_005138.3. NM_005147.5.
    UniGenei Hs.459779.

    3D structure databases

    ProteinModelPortali Q59E88.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q59E88.

    Protocols and materials databases

    DNASUi 9093.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9093.
    KEGGi hsa:9093.

    Organism-specific databases

    CTDi 9093.

    Phylogenomic databases

    HOVERGENi HBG051371.
    KOi K09504.

    Miscellaneous databases

    GenomeRNAii 9093.
    NextBioi 34071.

    Gene expression databases

    ArrayExpressi Q59E88.
    Bgeei Q59E88.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    2.10.230.10. 1 hit.
    HAMAPi MF_01152. DnaJ.
    InterProi IPR012724. DnaJ.
    IPR002939. DnaJ_C.
    IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    IPR008971. HSP40/DnaJ_pept-bd.
    IPR001305. HSP_DnaJ_Cys-rich_dom.
    [Graphical view ]
    Pfami PF01556. CTDII. 1 hit.
    PF00226. DnaJ. 1 hit.
    PF00684. DnaJ_CXXCXGXG. 1 hit.
    [Graphical view ]
    PRINTSi PR00625. JDOMAIN.
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    SSF49493. SSF49493. 1 hit.
    SSF57938. SSF57938. 1 hit.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    PS51188. ZF_CR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens protein coding cDNA."
      Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Aorta endothelial cellImported.

    Entry informationi

    Entry nameiQ59E88_HUMAN
    AccessioniPrimary (citable) accession number: Q59E88
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.