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Q59E88

- Q59E88_HUMAN

UniProt

Q59E88 - Q59E88_HUMAN

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Protein
Submitted name:

DnaJ (Hsp40) homolog, subfamily A, member 3 variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. metal ion binding Source: UniProtKB-KW
  3. small GTPase regulator activity Source: Ensembl

GO - Biological processi

  1. activation-induced cell death of T cells Source: Ensembl
  2. cell aging Source: Ensembl
  3. mitochondrial DNA replication Source: Ensembl
  4. negative regulation of programmed cell death Source: Ensembl
  5. positive regulation of T cell proliferation Source: Ensembl
  6. protein folding Source: InterPro
  7. response to heat Source: InterPro
  8. skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
  9. small GTPase mediated signal transduction Source: Ensembl
  10. T cell differentiation in thymus Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ChaperoneUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
DnaJ (Hsp40) homolog, subfamily A, member 3 variantImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extrinsic component of plasma membrane Source: Ensembl
  3. intracellular membrane-bounded organelle Source: HPA
  4. mitochondrion Source: HPA
  5. neuromuscular junction Source: Ensembl
  6. nucleus Source: Ensembl
  7. postsynaptic membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ59E88.

Expressioni

Gene expression databases

BgeeiQ59E88.
ExpressionAtlasiQ59E88. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ59E88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation

Phylogenomic databases

HOVERGENiHBG051371.
KOiK09504.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPiMF_01152. DnaJ.
InterProiIPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view]
PfamiPF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view]
PRINTSiPR00625. JDOMAIN.
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 1 hit.
SSF57938. SSF57938. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q59E88-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ARCSTRWLLV VVGTPRLPAI SGRGARPPRE GVVGAWLSRK LSVPAFASSL
60 70 80 90 100
TSCGPRALLT LRPGVSLTGT KHNPFICTAS FHTSAPLAKE DYYQILGVPR
110 120 130 140 150
NASQKEIKKA YYQLAKKYHP DTNKDDPKAK EKFSQLAEAY EVLSDEVKRK
160 170 180 190 200
QYDAYGSAGF DPGASGSQHS YWKGGPTVDP EELFRKIFGE FSSSSFGDFQ
210 220 230 240 250
TVFDQPQEYF MELTFNQAAK GVNKEFTVNI MDTCERCNGK GNEPGTKVQH
260 270 280 290 300
CHYCGGSGME TINTGPFVMR STCRRCGGRG SIIISPCVVC RGAGQAKQKK
310 320 330 340 350
RVMIPVPAGV EDGQTVRMPV GKREIFITFR VQKSPVFRRD GADIHSDLFI
360 370 380 390 400
SIAQALLGGT ARAQGLYETI NVTIPPGTQT DQKIRMGGKG IPRINSYGYG
410 420 430 440 450
DHYIHIKIRV PKRLTSRQQS LILSYAEDET DVEGTVNGVT LTSSGGSTMD
460 470
SSAGSKARRE AGEDEEGFLS KLKKMFTS
Length:478
Mass (Da):52,286
Last modified:May 10, 2005 - v1
Checksum:iF79D9A5FC3B18DD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209923 mRNA. Translation: BAD93160.1.
RefSeqiNP_005138.3. NM_005147.5.
UniGeneiHs.459779.

Genome annotation databases

GeneIDi9093.
KEGGihsa:9093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB209923 mRNA. Translation: BAD93160.1 .
RefSeqi NP_005138.3. NM_005147.5.
UniGenei Hs.459779.

3D structure databases

ProteinModelPortali Q59E88.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q59E88.

Protocols and materials databases

DNASUi 9093.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9093.
KEGGi hsa:9093.

Organism-specific databases

CTDi 9093.

Phylogenomic databases

HOVERGENi HBG051371.
KOi K09504.

Miscellaneous databases

GenomeRNAii 9093.
NextBioi 34071.

Gene expression databases

Bgeei Q59E88.
ExpressionAtlasi Q59E88. baseline and differential.

Family and domain databases

Gene3Di 1.10.287.110. 1 hit.
2.10.230.10. 1 hit.
HAMAPi MF_01152. DnaJ.
InterProi IPR012724. DnaJ.
IPR002939. DnaJ_C.
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
IPR008971. HSP40/DnaJ_pept-bd.
IPR001305. HSP_DnaJ_Cys-rich_dom.
[Graphical view ]
Pfami PF01556. CTDII. 1 hit.
PF00226. DnaJ. 1 hit.
PF00684. DnaJ_CXXCXGXG. 1 hit.
[Graphical view ]
PRINTSi PR00625. JDOMAIN.
SMARTi SM00271. DnaJ. 1 hit.
[Graphical view ]
SUPFAMi SSF46565. SSF46565. 1 hit.
SSF49493. SSF49493. 1 hit.
SSF57938. SSF57938. 1 hit.
PROSITEi PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
PS51188. ZF_CR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Homo sapiens protein coding cDNA."
    Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Aorta endothelial cellImported.

Entry informationi

Entry nameiQ59E88_HUMAN
AccessioniPrimary (citable) accession number: Q59E88
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.