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Q59E49

- Q59E49_DROME

UniProt

Q59E49 - Q59E49_DROME

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Protein
Submitted name:

HDAC4, isoform E

Gene
HDAC4, CG1770, Dmel_CG1770
Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. histone deacetylase activity Source: FlyBase

GO - Biological processi

  1. histone deacetylation Source: GOC
  2. regulation of transcription, DNA-templated Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotationsImported

Names & Taxonomyi

Protein namesi
Submitted name:
HDAC4, isoform EImported (EC:3.5.1.-Imported)
Gene namesi
Name:HDAC4Imported
ORF Names:CG1770Imported, Dmel_CG1770Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome X

Organism-specific databases

FlyBaseiFBgn0041210. HDAC4.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. nucleus Source: FlyBase
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ59E49.

Structurei

3D structure databases

ProteinModelPortaliQ59E49.
SMRiQ59E49. Positions 772-1149.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000062809.
KOiK11406.
OrthoDBiEOG7RFTH5.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q59E49-1 [UniParc]FASTAAdd to Basket

« Hide

MSSPDDRIPI HDLPSEAGSD ERLLHITPAT LTLDFKPHPA VDIDQQIMEL     50
KKSQELQKQR LINSFQEQSK QMELEHKLQL EHKYQFAVNS HGAFQELRNE 100
SMVTAAAAAV AQEQHRQQLH QQQQQHQQQQ QQQQHQQQQQ QQQARGRDGM 150
KLKQNCSANA SPEVKQILNC FILSRKSQAA ASNGTTTTSP YRNRGVVKSS 200
SGESLPAGTV TSAHPYKIPQ PPPSLLKYES DFPLRKTDCN STPDSGPNSP 250
PSAAALAVGV VGSRGSPTSA PIQEENEEGS QYQPGQRSSI NDLPLFSSPS 300
LPNISLGRPH LPNSAQAHAQ VNAQVAAQAQ AQAQAQAQAH AMFAALAAAQ 350
GGCGQPGYYN PLGMAFVGRQ PAPLAMIPAT GIAPQQPSPV VRSASATSTS 400
SSQASLVGDV APPQAHAAST ILPSSSSYMQ QLGSVAGSGV NLHAAAVAAA 450
AAAAAAAGSL PPTNSHGHGH GSHAHPHPHA HGHGHGHGHG IYAGHQHNVP 500
ITDAQVAQVH LHKQGHRPLG RTQSAPLPLG HPMLTGAVQL NVVQTHYENS 550
EAERQAYEHQ VVNQKVRQTV LTRSGAAAAA AAAAGVSVVR EAQLKEEDDD 600
SAAEVMDLTD KKKPPKTVLT STIATSTSQN LPEALAAAAA AAAYRAPHNA 650
SSNSASATKS GIKLRDQEYL QQQREQLLLL QQEEELAKSL MRPLSRTLSS 700
PLVPLGPHGL SQIPDTGQQP APIATSSSAD HIPPVNLSLP HRQHRQLMST 750
LYASQLRNHQ PSASGSPPHK VTTGLAYDPL MLKHSCICGD NAQHPEHSGR 800
LQSVWARLNE TDLVKRCDRL RARKATQEEL QTVHTEAHAM LFGSNQCQLS 850
RPKLENTLSA SFVRLSCGGL GVDLDTTWNE HHTATAARMA AGCVIDLALK 900
TAKGDLRNGF AVVRPPGHHA EANLAMGFCF FNSIAIAAKL LRQRMPEVRR 950
ILIVDWDVHH GNGTQQAFYQ SPDILYLSIH RHDDGNFFPG TGGPTECGSG 1000
AGLGFNVNIS WSGALNPPLG DAEYIAAFRT VVMPIARSFN PDIVLVSSGF 1050
DAATGHPAPL GGYHVSPACF GFMTRELLQL ANGKVVLALE GGYDLAAICD 1100
SAQECVRALL GDPAAPIAKA ELERPPCQNA INTLQKTIAI QQTHWPCVRM 1150
LEHTVGLSAL ETLKVEHDES ETINAMAGLS MQSMHRTLSR DDSEEPMDQD 1200
ETK 1203
Length:1,203
Mass (Da):128,636
Last modified:November 30, 2010 - v2
Checksum:iC41E58855E15AC44
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014298 Genomic DNA. Translation: AAX52490.2.
RefSeqiNP_001014736.2. NM_001014736.4.
UniGeneiDm.6484.

Genome annotation databases

EnsemblMetazoaiFBtr0301299; FBpp0290514; FBgn0041210.
GeneIDi32278.
KEGGidme:Dmel_CG1770.
UCSCiCG1770-RC. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014298 Genomic DNA. Translation: AAX52490.2 .
RefSeqi NP_001014736.2. NM_001014736.4.
UniGenei Dm.6484.

3D structure databases

ProteinModelPortali Q59E49.
SMRi Q59E49. Positions 772-1149.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0301299 ; FBpp0290514 ; FBgn0041210 .
GeneIDi 32278.
KEGGi dme:Dmel_CG1770.
UCSCi CG1770-RC. d. melanogaster.

Organism-specific databases

CTDi 9759.
FlyBasei FBgn0041210. HDAC4.

Phylogenomic databases

GeneTreei ENSGT00530000062809.
KOi K11406.
OrthoDBi EOG7RFTH5.

Miscellaneous databases

GenomeRNAii 32278.
NextBioi 777716.

Gene expression databases

Bgeei Q59E49.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
    Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
    Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
    Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
    Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  6. "Combined evidence annotation of transposable elements in genome sequences."
    Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
    PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
    Smith C.D., Shu S., Mungall C.J., Karpen G.H.
    Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.

Entry informationi

Entry nameiQ59E49_DROME
AccessioniPrimary (citable) accession number: Q59E49
Entry historyi
Integrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: November 30, 2010
Last modified: June 11, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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