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Protein

Histone deacetylase

Gene

HDAC4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi786ZincUniRule annotation1
Metal bindingi788ZincUniRule annotation1
Metal bindingi794ZincUniRule annotation1
Metal bindingi867ZincUniRule annotation1
Active sitei919UniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • histone acetylation Source: FlyBase
  • histone deacetylation Source: FlyBase
  • long-term memory Source: FlyBase
  • memory Source: FlyBase
  • regulation of gene expression, epigenetic Source: InterPro
  • regulation of transcription, DNA-templated Source: FlyBase
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotationImported, RepressorUniRule annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-DME-4551638. SUMOylation of chromatin organization proteins.
R-DME-8951936. RUNX3 regulates p14-ARF.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:HDAC4Imported
ORF Names:CG1770Imported, Dmel_CG1770Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0041210. HDAC4.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • histone deacetylase complex Source: UniProtKB-UniRule
  • nucleus Source: FlyBase

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ59E49.

Expressioni

Gene expression databases

BgeeiFBgn0041210.
ExpressionAtlasiQ59E49. differential.
GenevisibleiQ59E49. DM.

Structurei

3D structure databases

ProteinModelPortaliQ59E49.
SMRiQ59E49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini794 – 1108Hist_deacetylInterPro annotationAdd BLAST315

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili112 – 141Sequence analysisAdd BLAST30
Coiled coili540 – 567Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

GeneTreeiENSGT00530000062809.
KOiK11406.
OrthoDBiEOG091G0EQO.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR017320. Histone_deAcase_II_euk.
IPR030703. Histone_deacetylase_5.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PTHR10625:SF159. PTHR10625:SF159. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037911. HDAC_II_euk. 4 hits.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q59E49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPDDRIPI HDLPSEAGSD ERLLHITPAT LTLDFKPHPA VDIDQQIMEL
60 70 80 90 100
KKSQELQKQR LINSFQEQSK QMELEHKLQL EHKYQFAVNS HGAFQELRNE
110 120 130 140 150
SMVTAAAAAV AQEQHRQQLH QQQQQHQQQQ QQQQHQQQQQ QQQARGRDGM
160 170 180 190 200
KLKQNCSANA SPEVKQILNC FILSRKSQAA ASNGTTTTSP YRNRGVVKSS
210 220 230 240 250
SGESLPAGTV TSAHPYKIPQ PPPSLLKYES DFPLRKTDCN STPDSGPNSP
260 270 280 290 300
PSAAALAVGV VGSRGSPTSA PIQEENEEGS QYQPGQRSSI NDLPLFSSPS
310 320 330 340 350
LPNISLGRPH LPNSAQAHAQ VNAQVAAQAQ AQAQAQAQAH AMFAALAAAQ
360 370 380 390 400
GGCGQPGYYN PLGMAFVGRQ PAPLAMIPAT GIAPQQPSPV VRSASATSTS
410 420 430 440 450
SSQASLVGDV APPQAHAAST ILPSSSSYMQ QLGSVAGSGV NLHAAAVAAA
460 470 480 490 500
AAAAAAAGSL PPTNSHGHGH GSHAHPHPHA HGHGHGHGHG IYAGHQHNVP
510 520 530 540 550
ITDAQVAQVH LHKQGHRPLG RTQSAPLPLG HPMLTGAVQL NVVQTHYENS
560 570 580 590 600
EAERQAYEHQ VVNQKVRQTV LTRSGAAAAA AAAAGVSVVR EAQLKEEDDD
610 620 630 640 650
SAAEVMDLTD KKKPPKTVLT STIATSTSQN LPEALAAAAA AAAYRAPHNA
660 670 680 690 700
SSNSASATKS GIKLRDQEYL QQQREQLLLL QQEEELAKSL MRPLSRTLSS
710 720 730 740 750
PLVPLGPHGL SQIPDTGQQP APIATSSSAD HIPPVNLSLP HRQHRQLMST
760 770 780 790 800
LYASQLRNHQ PSASGSPPHK VTTGLAYDPL MLKHSCICGD NAQHPEHSGR
810 820 830 840 850
LQSVWARLNE TDLVKRCDRL RARKATQEEL QTVHTEAHAM LFGSNQCQLS
860 870 880 890 900
RPKLENTLSA SFVRLSCGGL GVDLDTTWNE HHTATAARMA AGCVIDLALK
910 920 930 940 950
TAKGDLRNGF AVVRPPGHHA EANLAMGFCF FNSIAIAAKL LRQRMPEVRR
960 970 980 990 1000
ILIVDWDVHH GNGTQQAFYQ SPDILYLSIH RHDDGNFFPG TGGPTECGSG
1010 1020 1030 1040 1050
AGLGFNVNIS WSGALNPPLG DAEYIAAFRT VVMPIARSFN PDIVLVSSGF
1060 1070 1080 1090 1100
DAATGHPAPL GGYHVSPACF GFMTRELLQL ANGKVVLALE GGYDLAAICD
1110 1120 1130 1140 1150
SAQECVRALL GDPAAPIAKA ELERPPCQNA INTLQKTIAI QQTHWPCVRM
1160 1170 1180 1190 1200
LEHTVGLSAL ETLKVEHDES ETINAMAGLS MQSMHRTLSR DDSEEPMDQD

ETK
Length:1,203
Mass (Da):128,636
Last modified:November 30, 2010 - v2
Checksum:iC41E58855E15AC44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA. Translation: AAX52490.2.
RefSeqiNP_001014736.2. NM_001014736.5.
UniGeneiDm.6484.

Genome annotation databases

EnsemblMetazoaiFBtr0301299; FBpp0290514; FBgn0041210.
GeneIDi32278.
KEGGidme:Dmel_CG1770.
UCSCiCG1770-RC. d. melanogaster.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ59E49_DROME
AccessioniPrimary (citable) accession number: Q59E49
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: November 30, 2010
Last modified: July 5, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported