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Q59E49

- Q59E49_DROME

UniProt

Q59E49 - Q59E49_DROME

Protein
Submitted name:

HDAC4, isoform E

Gene

HDAC4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone deacetylase activity Source: FlyBase

    GO - Biological processi

    1. histone deacetylation Source: GOC
    2. regulation of transcription, DNA-templated Source: FlyBase

    Keywords - Molecular functioni

    HydrolaseSAAS annotationImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HDAC4, isoform EImported (EC:3.5.1.-Imported)
    Gene namesi
    Name:HDAC4Imported
    ORF Names:CG1770Imported, Dmel_CG1770Imported
    OrganismiDrosophila melanogaster (Fruit fly)Imported
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome X

    Organism-specific databases

    FlyBaseiFBgn0041210. HDAC4.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. nucleus Source: FlyBase

    Expressioni

    Gene expression databases

    BgeeiQ59E49.

    Structurei

    3D structure databases

    ProteinModelPortaliQ59E49.
    SMRiQ59E49. Positions 772-1149.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000062809.
    KOiK11406.
    OrthoDBiEOG7RFTH5.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q59E49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPDDRIPI HDLPSEAGSD ERLLHITPAT LTLDFKPHPA VDIDQQIMEL     50
    KKSQELQKQR LINSFQEQSK QMELEHKLQL EHKYQFAVNS HGAFQELRNE 100
    SMVTAAAAAV AQEQHRQQLH QQQQQHQQQQ QQQQHQQQQQ QQQARGRDGM 150
    KLKQNCSANA SPEVKQILNC FILSRKSQAA ASNGTTTTSP YRNRGVVKSS 200
    SGESLPAGTV TSAHPYKIPQ PPPSLLKYES DFPLRKTDCN STPDSGPNSP 250
    PSAAALAVGV VGSRGSPTSA PIQEENEEGS QYQPGQRSSI NDLPLFSSPS 300
    LPNISLGRPH LPNSAQAHAQ VNAQVAAQAQ AQAQAQAQAH AMFAALAAAQ 350
    GGCGQPGYYN PLGMAFVGRQ PAPLAMIPAT GIAPQQPSPV VRSASATSTS 400
    SSQASLVGDV APPQAHAAST ILPSSSSYMQ QLGSVAGSGV NLHAAAVAAA 450
    AAAAAAAGSL PPTNSHGHGH GSHAHPHPHA HGHGHGHGHG IYAGHQHNVP 500
    ITDAQVAQVH LHKQGHRPLG RTQSAPLPLG HPMLTGAVQL NVVQTHYENS 550
    EAERQAYEHQ VVNQKVRQTV LTRSGAAAAA AAAAGVSVVR EAQLKEEDDD 600
    SAAEVMDLTD KKKPPKTVLT STIATSTSQN LPEALAAAAA AAAYRAPHNA 650
    SSNSASATKS GIKLRDQEYL QQQREQLLLL QQEEELAKSL MRPLSRTLSS 700
    PLVPLGPHGL SQIPDTGQQP APIATSSSAD HIPPVNLSLP HRQHRQLMST 750
    LYASQLRNHQ PSASGSPPHK VTTGLAYDPL MLKHSCICGD NAQHPEHSGR 800
    LQSVWARLNE TDLVKRCDRL RARKATQEEL QTVHTEAHAM LFGSNQCQLS 850
    RPKLENTLSA SFVRLSCGGL GVDLDTTWNE HHTATAARMA AGCVIDLALK 900
    TAKGDLRNGF AVVRPPGHHA EANLAMGFCF FNSIAIAAKL LRQRMPEVRR 950
    ILIVDWDVHH GNGTQQAFYQ SPDILYLSIH RHDDGNFFPG TGGPTECGSG 1000
    AGLGFNVNIS WSGALNPPLG DAEYIAAFRT VVMPIARSFN PDIVLVSSGF 1050
    DAATGHPAPL GGYHVSPACF GFMTRELLQL ANGKVVLALE GGYDLAAICD 1100
    SAQECVRALL GDPAAPIAKA ELERPPCQNA INTLQKTIAI QQTHWPCVRM 1150
    LEHTVGLSAL ETLKVEHDES ETINAMAGLS MQSMHRTLSR DDSEEPMDQD 1200
    ETK 1203
    Length:1,203
    Mass (Da):128,636
    Last modified:November 30, 2010 - v2
    Checksum:iC41E58855E15AC44
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAX52490.2.
    RefSeqiNP_001014736.2. NM_001014736.4.
    UniGeneiDm.6484.

    Genome annotation databases

    EnsemblMetazoaiFBtr0301299; FBpp0290514; FBgn0041210.
    GeneIDi32278.
    KEGGidme:Dmel_CG1770.
    UCSCiCG1770-RC. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014298 Genomic DNA. Translation: AAX52490.2 .
    RefSeqi NP_001014736.2. NM_001014736.4.
    UniGenei Dm.6484.

    3D structure databases

    ProteinModelPortali Q59E49.
    SMRi Q59E49. Positions 772-1149.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0301299 ; FBpp0290514 ; FBgn0041210 .
    GeneIDi 32278.
    KEGGi dme:Dmel_CG1770.
    UCSCi CG1770-RC. d. melanogaster.

    Organism-specific databases

    CTDi 9759.
    FlyBasei FBgn0041210. HDAC4.

    Phylogenomic databases

    GeneTreei ENSGT00530000062809.
    KOi K11406.
    OrthoDBi EOG7RFTH5.

    Miscellaneous databases

    GenomeRNAii 32278.
    NextBioi 777716.

    Gene expression databases

    Bgeei Q59E49.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    3. Cited for: GENOME REANNOTATION.
      Strain: BerkeleyImported.
    4. "The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective."
      Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., Celniker S.E.
      Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    5. "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."
      Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., Karpen G.H.
      Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    6. "Combined evidence annotation of transposable elements in genome sequences."
      Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., Ashburner M., Anxolabehere D.
      PLoS Comput. Biol. 1:166-175(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    7. "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."
      Smith C.D., Shu S., Mungall C.J., Karpen G.H.
      Science 316:1586-1591(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: BerkeleyImported.

    Entry informationi

    Entry nameiQ59E49_DROME
    AccessioniPrimary (citable) accession number: Q59E49
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 26, 2005
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3